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| 1 | Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study显示文摘BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage(CAL)through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.AIM To reach consensus on the definition of CAL using a modified Delphi method.METHODS The RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.RESULTSTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items(80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16(84%) agreed with our final recommendations for the definition of CAL.CONCLUSION A consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field. | Claire PM van Helsdingen Audrey CHM Jongen Wouter J de Jonge Nicole D Bouvy Joep PM Derikx | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 2 | Overlapping immunoglobulin G4-related disease and Rosai-Dorfman disease mimicking lung cancer显示文摘 | de Jong WK Kluin PM Groen HM | 2012 | Eur Respir Rev2012，21，126： | 1 |
| 3 | Changed patterns of cerebral activation related to clinically normal hand movement in cervical dystonia 显示文摘 | de Vries PM Johnson KA de Jong BM | 2008 | Clin Neurol Neurosurg2008，1110，2： | 1 |
| 4 | Effect of C1 inhibitor on inflammatory and physiologic response patterns in primates suffering from lethal septic shock 显示文摘 | Jansen PM Eisele B de Jong IW | 1998 | J lmmunol1998，160，1： | 1 |
| 5 | Construction of small-insert genomic DNA libraries highly enriched for microsatellite repeat sequences 显示文摘 | OSTRANDER EA JONG PM RINE J | 1992 | Proceedings of the National Academy of Sciences USA1992，，89： | 1 |
| 6 | Surgical treatment of giant haemangioma of the liver显示文摘 | Browners MA Peeters PM de - Jong KP | 1997 | Br J Surg1997，84，3： | 1 |
| 7 | Lake Volkerak-Zoom: a lake shifting from the clear to the turbid state显示文摘 | BREUKERS C PM VAN DAM E M DE JONG S A | 1997 | Hydrobiologia1997，，0： | 1 |
| 8 | Visualization of a- nomalous coronary arteries on dual - source computed tomography 显示文摘 | de Jonge GJ van Ooijen PM Piers LH | 2008 | Eur Radio12008，18，11： | 1 |
| 9 | What are the characteristics of the competent general practitioner trainer? 显示文摘 | Boendermaker PM Schuling J Jong BM | 2000 | Family Practice2000，17，6： | 1 |
| 10 | What are the characteristics of the competent general practitioner trainer?显示文摘 | Boendermaker PM Schuling J Jong BM | 2000 | Family Practice2000，17，6： | 1 |
| 11 | Construction of small-insert genomic DNA libraries highly enriched for microsatellite repeat sequences显示文摘 | Ostrander EA Jong PM Rine J | 1992 | Proc Natl Acad Sci U S A1992，89，： | 1 |
| 12 | Changed patterns of cerebral activation related to clinically normal hand movement in cervical dystonia显示文摘 | De Vries PM Johnson KA De Jong BM | 2008 | Clin Neurol Neurosurg2008，110，： | 1 |
| 13 | Random- ized placebo-controlled trial assessing a treatment strategy consis- ting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to mod- erate CKD显示文摘 | Nanayakkara PW Kiefte-de Jong JC ter Wee PM | 2009 | Am J Kidney Dis2009，53，1： | 1 |
| 14 | Informatics in radiolo-gy :postprocessing pitfalls in using CT for automatic and semiauto-matic determination of global left ventricular function 显示文摘 | van Ooijen PM de Jonge GJ Oudkerk M | 2012 | Radio-graphics2012，32，2： | 1 |
| 15 | Age andsex based reference values for incidental coronaryartery and thoracic aorta calcifications on routineclinical chest CT:a powerful tool to appreciateavailable imaging findings显示文摘 | Jairam PM de Jong PA Mali WP | 2014 | Atherosclerosis2014，235，： | 1 |
| 16 | Added value ofmolecular biological analysis in diagnosis and clinical managementof liposarcoma:A 30-year single-institution experience显示文摘 | de Vreeze RS de Jong D Nederlof PM | 2010 | AnnSurg Oncol2010，17，3： | 1 |
| 17 | Randomized placebo - controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD 显示文摘 | Nanayakkara PW Kiefte - de - Jong JC ter - Wee PM | 2009 | AmJKidnevDis2009，53，1： | 1 |
| 18 | Construction of small insert genomic DNA libraries highly enriched for microsatellite repeat sequences显示文摘 | Ostrander EA Jong PM Rine J | 1992 | Proceedings of the National Academy of Sciences of the United States of America1992，89，8： | 1 |
| 19 | Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin,vitamin E,and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD显示文摘 | Nanayakkara PW Kiefte-de Jong JC ter Wee PM | 2009 | Am J Kidney Dis2009，53，1： | 1 |
| 20 | Construction of small-insert genomic DNA libraries highly enriched for microsatellite repeat sequences显示文摘 | Ostrander EA Jong PM Rine J Duyk G | | 0，，08： | 1 |
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