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| 1 | Is there a place for optimizing thoracic radiotherapy in limited-stage small cell lung cancer after twenty years?显示文摘Thoracic radiotherapy(TRT)is one of the main treatments in limited-stage small cell lung cancer(LS-SCLC).Hyperfractionated TRT(45 Gy,1.5 Gy twice daily)has been the standard of care(SOC)since Turrisi and colleagues published the results of their clinical trial in 1999.Two meta-analyses have demonstrated the benefits of concurrent chemotherapy and TRT in terms of intrathoracic disease control at 2 years and 3-year overall survival(OS).The phase 2 trial by Grønberg et al(2016)comparing once-daily hypofractionated TRT to twice-daily hyperfractionated TRT in LS-SCLC found similar outcomes in both groups in terms of response rate,progression-free survival(PFS),grade 3-4 adverse effects,and OS.The CONVERT trial,published in 2017,failed to demonstrate the superiority of the conventional scheme(once-daily TRT)vs twice-daily radiotherapy,despite the application of modern radiotherapy techniques and a quality assurance programme,thus confirming the twice-daily hyperfractionated regimen as the SOC.At the 2020 American Society of Clinical Oncology(ASCO)annual meeting,Grønberg et al reported preliminary findings from a phase 2 trial comparing two different TRT dose regimens(45 Gy vs 60 Gy),both administered twice daily.Those data demonstrated a marked improvement in 2-year survival rates in the high dose arm(70.2%vs 46.1%,P=0.002),despite similar objective response rates and PFS outcomes.Those findings provide a new treatment alternative to consider:Hyperfractionated,high-dose TRT.However,the results of that trial will need to be validated in a large,randomized phase 3 study.The results of the phase 2 CALCG 30610 trial will help to clarify the optimal dose and regimen.The potential role of upfront immunotherapy,which early data suggest may improve OS,also needs to be determined. | Jose Maximo Barros Manglio Miguel Rizzo Jorge Oscar Chiozza Felipe Counago | 2021 | World Journal of Clinical Oncology2021，12，1： | 2 |
| 2 | Bond between near-surface mounted carbon- fiber- reinforced polymer laminate strips and concrete显示文摘 | Jose Manuel de Sena Cruz Joaquim Antenio Oliveira de Barros | 2004 | Journal of Composites for Construction2004，8，6： | 1 |
| 3 | Predictors of Loneliness Among Students and Nuns in Angola and Portugal显示文摘 | FELIX NETO JOSE BARROS | 2003 | The Journal of Psychology2003，137，4： | 1 |
| 4 | Psychosocial concomitants of loneliness a- mong students of Cape Verde and Portugal 显示文摘 | Felix Neto Jose Barros | 2000 | The Journal of Psy- chology2000，134，5： | 1 |
| 5 | Modeling silicon and aluminum diffusion in electrical steel显示文摘 | Jose Barros Yvan Houbaert Benny Malengier Roger Keer | 2005 | Journal of Phase Equilibria and Diffusion2005，，5： | 1 |
| 6 | Low- Wage employment in Portugal: A Mixed Logit Approach 显示文摘 | Carlos Pestana Barros Isabel Proenca Jose Cabral Vieira | 2005 | IZA Discussion Paper2005，1667，： | 1 |
| 7 | Modeling of bond between near-surface mounted CFRP laminate strips and concrete显示文摘 | Cruz Jose Sena Barros Joaquim | 2004 | Computers and Structures2004，85，1719： | 1 |
| 8 | Efficiency of different techniques in flexural strengthening of RC beams under monotonic and fatigue loading 显示文摘 | JOSE M JOAQUIM A O BARROS R F | 2012 | Construction and Building Materials2012，29，： | 1 |
| 9 | An Evaluation of Alternative Techniques for Monitoring Insulator Pollution显示文摘 | Jose Mauricio de Barros Bezerra Jose Mauricio de Barros Bezerra | 2009 | IEEE Transactions on Power Delivery2009，24，4： | 1 |
| 10 | Technical and allocative efficiency in a chain of small hotels显示文摘 | Carlos Pestana Barros Maria Jose Mascarenhas | 2005 | Hospital Management2005，，24： | 1 |
| 11 | Costi-tuents of the Leaves of Magnolia ovata显示文摘 | Barros Leticia Ferrari L Barison Andersson Salvador Marcos Jose | 2009 | Journal of Natural Products2009，，8： | 1 |
| 12 | E valuating Carbon Emissions Reduction by Use of Natural Gas as Engine显示文摘 | Paola Helena Barros Za'rante Jose'Ricardo Sodre' | | 0，，01： | 1 |
| 13 | Procalcitonin and C-reactive protein levels as diagnostic tools in febrile patients admitted to a General Internal Medicine ward显示文摘 | Raul Ruiz-Esteban Pilar Relea Sarabia Emilio García Delgado Carlos Barros Aguado Jose Amerigo Cuervo-Arango Manuel Varela | 2011 | Clinical Biochemistry2011，，1： | 1 |
| 14 | 6%的羟乙基淀粉-高渗盐水在失血性休克狗复苏时的作用显示文摘背景血流动力学和全身氧输送的变化无法反映内脏低灌注,从而导致无法认识到对失血性休克的处理不足。液体复苏后扩容对改善失血性休克时全身和局部的氧供是必不可少的。我们假设,与传统的代血浆相比,应用少量的扩容剂7.5氯化钠/6%羟乙基淀粉(hydroxyethyl starch.hypertonic saline,HHES)溶液,可能提供较少的全身氧输送和胃血流灌注。我们为失血的狗进行临床上严重出血时常用的固定量液体单次输注,分别观察HHES、乳酸林格液(1actatedRinger,LR)和6%羟乙基淀粉(hydroxyethyl starch,HES)溶液对血管内扩容、早期全身氧合和胃灌注的影响。方法30只狗,出血30ml/kg,保持平均动脉压在40~50mmHg,持续45分钟后,分3组进行复苏:LR组(n=10),输注3倍出血量的液体;HES组(平均分子量130KDa,替代级0.4)(n=10),输注出血量等量的液体;HHES组(n=10),以4ml/kg的速度输注。测定血管内容量增加情况(用Evans蓝和血红蛋白稀释)、血流动力学、全身氧合、静动脉CO2分压差(Pv-aco2)和胃黏膜-动脉血CO2分压差(Pco2间隙)变化,测定时间点为基础值、出血45分钟后以及液体复苏5分钟、45分钟、90分钟时。结果由于HHES的高扩容效力增加了血容量,但它对血管内容量的扩张作用是各溶液中最小的(P〈0.05)。3种溶液对血流动力学影响相同,但相对于LR组和HES组,HHES组相混合静脉血Po,更低,全身氧合、Pv-aco2和胃黏膜Pco2间隙更大(P〈0.05)。结论对狗进行按血压调节的失血性休克和固定容量的复苏,尽管HHES有高效扩容作用,但相比LR和HES,由于输注量受限,它的血管内容量扩充能力较小,全身氧合和胃血流灌注较差。 | Joao M. P. Barros Paulo do Nascimento Joao Luiz P. Marinello Leandro G. Braz Lidia R. Carvalho Luiz A. Vane Yara M. M. Castiglia Jose R. C. Braz | 2012 | 麻醉与镇痛2012，8，5： | 0 |
| 15 | Electrical cardioversion for supraventricular arrhythmias in octagenarians显示文摘Atrial fibrillation(AF)is the most common arrhythmia in the elderly and its incidence increases with aging.[1]Electrical cardioversion is used as a strategy for rhythm control in patients with supraventricular arrhythmias.In octagenarians,there are challenges associated with the indication for electrical cardioversion,such as the use of appropriate sedation and anticoagulant agents.Most decisions in clinical practice for these patients derive from observational data and personal experience,since octagenarians represent a minority of patients included in randomized clinical trials.Little evidence is available regarding the clinical context of electrical cardioversion in this vulnerable population.Therefore,we aimed to describe the clinical profile of octagenarians undergoing electrical cardioversion in a cardiology reference center from 2014 to 2018. | Felipe L.Malafaia Patrícia O.Guimarães Márcio C.Sampaio Pedro G.M.de Barros e Silva Renato D.Lopes Juliano V.Custódio Miguel da S.Diniz Jose C.T.Garcia Valter Furlan | 2019 | Journal of Geriatric Cardiology2019，16，12： | 0 |
| 16 | Sediment transport under the presence and absence of emergent vegetation in a natural alluvial channel from Brazil显示文摘Studies regarding the influence of emergent vegetation on sediment transport are scarce and have mainly focused on flume conditions.To fill this gap and also meet the international need,we aimed to evaluate the influence of emergent vegetation(Echinodorus macrophyllus) on sediment transport of Capibaribe River,Brazil.Bedload and suspended sediment measurements were carried out using the US BLH 84 and US DH 48 samplers,respectively.Measurements of stem diameter,stem spacing and plant density were performed in conjunction with flow and sediment field measurements.Based on our results,0.45 m s^(-1) was the threshold of mean flow velocity supported by E.macrophyllus under field conditions.This value can be helpful for other rivers with gravel-bed river to armoured layer ratio(AR=D_(50-surface))/D_(50-subsurface)=12.50)-natural conditions observed in Capibaribe River-or where the vegetation can provide positive effects,such as increase the bed stability,assist water restoration/rehabilitation and decrease water turbidity.Our results can hopefully be used in engineering practice and ecosystem management.In general,both the drag coefficient and drag force varied inversely and directly with the mean flow velocity and vegetation density,respectively.The vegetation resistance force was inversely proportional to the bedload transport owing to the resistance caused by emergent vegetation.This finding was supported by the clear decoupling between nonvegetated and emergent vegetated conditions indicated by cluster analysis.The study results provided a reasonable understanding of the interaction between emergent vegetation,water flow and sediment transport in the Capibaribe River. | Yuri Jacques Agra Bezerra da Silva Jose Ramon Barros Cantalice Vijay P. Singh Cinthia Maria Cordeiro Atanazio Cruz Wagner Luis da Silva Souza | 2016 | International Journal of Sediment Research2016，31，4： | 0 |
| 17 | Analysis of Fatigue Fracture with Scanning Electron Microscopy of Valve Spring Steel显示文摘 | Marcelo Sampaio Martins Daniel Julien Barros da Silva Sampaio Jose Geraldo Trani Brandao Jose Elias Tomazini | 2014 | Journal of Mechanics Engineering and Automation2014，4，5： | 0 |
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