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| 1 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Theory of mind, emotion understanding, language,and family background:individual differences and interrelations显示文摘 | | 1999 | Child development1999，，70： | 1 |
| 4 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 5 | Meiosis I arrest and a-zoospermia in an infertile male explained by failure of for-mation of a component of the synaptonemal complex显示文摘 | Judis L Chan ER Schwartz S | 2004 | Fertil Steril2004，81，1： | 1 |
| 6 | Cleaning up agriculture:environment,technology and social science显示文摘 | JUDY CLARK P L | 1992 | Sociologia Ruralis1992，32，1： | 1 |
| 7 | Methylmercury induces oxidantive injurys, alterations in permeability and glutamine transpot in cultures astrocytes 显示文摘 | Zhaobao Yin Dejan Milatovic Judy L | 2007 | Brain Research2007，，1131： | 1 |
| 8 | Bisphenol Ais released from used polycarbonate animal cages into water atroom temperature 显示文摘 | Howdeshell K L Peterman P H Judy B M | 2003 | Environmental Health Perspectives2003，111，9： | 1 |
| 9 | Use of Pharmacologic Interventions for Breast Cancer Risk Reduction: American Society of Clinical Oncology Clinical Practice Guideline显示文摘 | Kala Visvanathan Patricia Hurley Elissa Bantug Powel Brown Nananda F. Col Jack Cuzick Nancy E. Davidson Andrea DeCensi Carol Fabian Leslie Ford Judy Garber Maria Katapodi Barnett Kramer Monica Morrow Barbara Parker Carolyn Runowicz Victor G. Vogel James L | 2013 | Journal of Clinical Oncology2013，，23： | 1 |
| 10 | Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products 显示文摘 | Judy L Raucy | 2003 | Drug Metabolism and Disposition2003，31，5： | 1 |
| 11 | Provision of Sport Psychology Services at an International Competition:The ⅩⅥ Maccabiah Games显示文摘 | JUDY L VAN RAALTE | 2003 | Sport Psychol2003，17，： | 1 |
| 12 | DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with highexposure to coal combustion emissions and high lung cancer mortality 显示文摘 | JUDY L MUMFORD X L JOELLEN L | 1993 | Environmental Health Perspectives1993，99，： | 1 |
| 13 | The Relationship between Hardiness,College Adjustment and Academic Performance显示文摘 | Kafka Judy L | 2001 | Dissertation Abstracts International:Section B The Sciences&Engineering2001，62，6： | 1 |
| 14 | Volatile constituents of litchi显示文摘 | Johnston Judy C Welch Ronald C Hunter G L K | 1980 | Journal of Agricultural and Food Chemistry1980，28，4： | 1 |
| 15 | Tumour markers for prostate cancer显示文摘 | Judy L | 2000 | HkSCCCommumcations2000，3，1： | 1 |
| 16 | Hydrothermal carbonization of biomass residuals: a comparative review of the chemistry, processes and applications of wet and dry pyrolysis 显示文摘 | JUDY A L KYOUNG S R CLAUDIA K | 2011 | Biofuels2011，1，2： | 1 |
| 17 | Metal toxicity and metallothionein gene expression studies in common Carp and Tilapia显示文摘 | KOWK L L PO W K JUDY K Y W | 1998 | Marine Environmental Research1998，46，1： | 1 |
| 18 | A Review of Modelsand Micrometeorological Methods Used to Estimate WetlandEvapotranspiration显示文摘 | Judy Z D Richard L S Donatella S | 2004 | Hydrological Process2004，18，： | 1 |
| 19 | Inactivation of viruses with photoactive compounds 显示文摘 | F Sogandares - Bernal MM Judy | 1992 | Blood Cells1992，18，： | 1 |
| 20 | A review of models and micrometeorological methods used to estimate wetland evapotranspiration显示文摘 | Judy Z Drexler Richard L Snyder Donatella Spano | 2004 | Hydrological Processes2004，，18： | 1 |
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