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| 1 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 2 | 智慧城市:数字技术打造宜居家园显示文摘历经十年的探索之后,智慧城市的发展走进了一个新阶段。尽管数字技术只是打造美好城市的其中一项工具,但它的确是近年来最有成效的办法之一。本报告分析了当前全球智慧城市采用的近60项应用,发现这些应用可将城市生活质量的指标提高10%~30%。报告同时发现,即便是走在世界最前沿的智慧城市也仍然具有巨大的进步空间。 | 华强森 吕文博 Jaana Remes Brodie Boland | 2018 | 科技中国2018，，10： | 2 |
| 3 | Childhood family problems and current psychiatric problems among young violent and property offenders显示文摘 | Jaana H Tiina H | 1996 | J Am Acad Child Adolesc Psychiatry1996，35，10： | 1 |
| 4 | CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines 显示文摘 | Wang Y F Kelly C G Jaana T | 2001 | Immunity2001，15，6： | 1 |
| 5 | Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention:follow-up of the Finnish Diabetes Prevention Study显示文摘 | Jaana LD Pirjo IP Markku P | 2006 | Lancet2006，368，9548： | 1 |
| 6 | Detection of microeystins with protein phosphatase inhibition assay,high-performan celiquid chromatography-UV detection and enzyme-linked immunosorbent assay Comparison of methods显示文摘 | Jarkko Rapala Kirsti Erkomaa Jaana Kukkonen | 2002 | Ana1 Chim Acta2002，466，2： | 1 |
| 7 | The Process of Business Relationship Ending Its Stage and Actors 显示文摘 | Jaana Tahtinen | 2002 | Journal of Market - Focused Management2002，5，4： | 1 |
| 8 | Invasive Group A Streptococcal Infections in Children: A Nationwide Survey in Finland显示文摘 | Terhi Tapiainen Saana Launonen Marjo Renko Harri Saxen Eeva Salo Matti Korppi Leena Kainulainen Tarja Heiskanen-Kosma Laura Lindholm Jaana Vuopio Tiina Huotari Jarmo Rusanen Matti Uhari | 2016 | The Pediatric Infectious Disease Journal2016，，： | 1 |
| 9 | Business Relationships Facing the End: Why Restore Them? 显示文摘 | Tahtinen Jaana Vaaland Terje I | 2006 | Journal of Business & Industrial Marketing2006，21，1： | 1 |
| 10 | TheFinnish diabetes prevention study: lifestyle intervention and 3-yearresults on diet and physical activity显示文摘 | Jaana Lindstrm Anne Louheranta Marjo Mannelin | 2003 | Diabetes Care2003，26，12： | 1 |
| 11 | Human Papillomavirus Genotypes in Male Genitalia and Their Concordance among Pregnant Spouses Participating in the Finnish Family HPV Study显示文摘 | Katja K Jaana R Kari S | 2011 | The Journal of Sexual Medicine2011，8，9： | 1 |
| 12 | Buffer zones and constructed wetlands as filters for agricultural phosphorus显示文摘 | JAANA U K BENT B HAKAN J | 2000 | Journal Environmental Quality2000，29，： | 1 |
| 13 | Physical activity in the prevention of type 2 diabetes显示文摘 | David EL Jaana L Timo AL | 2005 | Diabetes2005，54，1： | 1 |
| 14 | The Most Dynamic Cities of 2025 显示文摘 | Ridard Dobbs Jaana Remes | 2012 | Foreign Policy2012，，： | 1 |
| 15 | Cumulated gain- based evaluation of IR techniques显示文摘 | Kalervo Jarvelin Jaana Kekalainen | 2002 | ACM Transactions on Information Systems2002，20，4： | 1 |
| 16 | A decision support tool to prioritize risk management options for contaminated sites 显示文摘 | JAANA S JYRI S | 2010 | Sci Total Environ2010，408，： | 1 |
| 17 | Apolipoprotein A-I, apolipoprotein B, and apolipoprotein B /apolipopro- tein A-I ratio:Reference intervals compared with values in different pathophysiological conditions from the FINRISK 2007 study显示文摘 | JAANA L JOUKO S GEORG A | 2011 | Clinica Chimica Acta2011，412，： | 1 |
| 18 | Cumulated gain-based evaluation of IR techniques显示文摘 | Kalervo J?rvelin Jaana Kek?l?inen | 2002 | ACM Transactions on Information Systems (TOIS)2002，，4： | 1 |
| 19 | Phytoplankton community responses to nutrient and iron enrichment under different nitrogen to phosphorus ratios in the northern Baltic Sea显示文摘 | Kristiina V Annika L Jaana M | 2005 | Journal of Experimental Marine Biology and Ecology2005，322，： | 1 |
| 20 | Association between ghrelin gene variations and blood pressure in subiects with impaired glucose tolerance显示文摘 | Ursula M Marjukka K Jaana L | 2006 | Am J Hypertens2006，19，9： | 1 |
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