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367篇 您的检索式：作者名="Jacobsen G"

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	题名	作者	年代	出处	被引量
1	Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients.	Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen	2019	Cellular & Molecular Immunology2019，16，3：	15
2	Childhood myelodysplastic syndrome in Denmark:incidene and predisposing conditions显示文摘	H Kemdrup G Jacobsen B B	1995	Leukemia1995，9，：	1
3	Free,complexed and total serum prostate specific antigen:The establishment of appropriate reference ranges for their concentration and rations显示文摘	Oesterling J E Jacobsen S J Klee G	1999	Urol1999，154，：	1
4	A wave generation toolbox for the open-source CFD library: OpenFOAM? 显示文摘	JACOBSEN N G FUHRMAN D R FREDS E J	2012	International Journal for Numerical Methods in Fluids2012，70，9：	1
5	Filling of poly(lactic acid)with native starch显示文摘	Jacobsen S Fritzh G	1996	Polymer Engineering and Science1996，36，22：	1
6	Visual function and patient satisfaction:comparison between bilateral diffractive multifocal intraocular lenses and monovision pseudophakia显示文摘	Zhang F Sugar A Jacobsen G	2011	Cataract Refract Surg2011，37，3：	1
7	Open Pulled Straw(OPS) Vitrifica- tion: a New Way to Reduce Cryoinjuries of Bovine Ova and Embryos 显示文摘	Vajta G Holm P Kuwayama M Booth P J Jacobsen H Greve T Callesen H	1998	Molecular Reproduction and Develop- ment1998，51，1：	1
8	Reli- ability and validity of the Ocular Surface Disease Index显示文摘	Schiffman RM Christianson MD Jacobsen G	2000	Arch Ophthalmol2000，118，5：	1
9	Clinical dentin hypersensitivity: understanding the causes and prescribing a treatment显示文摘	Jacobsen PL Bruce G	2001	J Contemp Dent Pract2001，2，1：	1
10	Reliability and validity of the ocular surface disease index显示文摘	Schiffman RM Christianson MD Jacobsen G	2000	Arch Ophthalmol2000，118，5：	1
11	Filling of Poly (lactic acid)with Native Starch显示文摘	Jacobsen S Fritz H G	1996	Polymer Engineering and Science1996，36，22：	1
12	Small-molecule H-bond donors in asymmetric catalysis 显示文摘	Doyle A G Jacobsen E N	2007	Chem Rev2007，107，12：	1
13	Clinicai hypersen sitivity:undertanding the cause ang prescribing a treatment 显示文摘	Jacobsen pl Brua G	2001	cowtemp Dent praet2001，2，1：	1
14	Sec- ondary somatic embryogenesis and applications in plant breeding 显示文摘	Raemakers C J J M Jacobsen E Visser R G F	1995	Euphytica1995，81，1：	1
15	Predictors of length of stay and patient satisfaction after hip and knee replacement surgery:fast-track experience in 712 patients显示文摘	Husted H Holm G Jacobsen S	2008	Acta Orthop2008，79，2：	1
16	Effects of increacing maintenance dose of digoxin on left ventricular function and neurohormones in patients with chronic heart failure treated with diuretics and angiotensin-converting enzyme inhibitors 显示文摘	Hall VB Jacobsen G Alam M Rasman H Goldstein S	1995	Circulation,1995;92:1808~18171995，92，：	1
17	Plasticizing polylactide - the effect of different plasticizers on the mechanical properties 显示文摘	Jacobsen S Fritz H G	1999	Polym Eng Sci1999，39，：	1
18	Arabidopsis research 2001显示文摘	Eckardt NA Araki T Benning C Cubas P Goodrich J Jacobsen SE Masson P Nambara E Simon R Somerville S Wasteneys G		0，，09：	1
19	Critical residues influence the affinity and selectivity of alpha-cono- toxin MI for nicotinic acetylcholine receptors 显示文摘	Jacobsen R B DelaCruz R G Grose J H	1999	Bio- them1999，38，13：	1
20	Isolation and characterisation of a virus infecting Phaeocystis pouchetii (Prymnesiophyceae)显示文摘	Jacobsen A Bratbak G Heldal M	1996	J Phycol1996，32，：	1

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