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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 3 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 4 | Effect of stress state on the stress-induced martensitic transformation in polycrystalline Ni-Ti alloy显示文摘 | Jacobus K Sehitoglu H Balzer M | 1996 | Metall Trans1996，27，10： | 1 |
| 5 | 18F-2fluro-2-deoxy-Dglucose positron emission tomography in staging of locallgadvanced breast cancer显示文摘 | Jacobus JM Vander H Nanda CK | 2004 | J Clin Oncol2004，22，7： | 1 |
| 6 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 7 | Liberal Arts: Education and Employability 显示文摘 | Jacobus P H | 1973 | Allied Health Occupations1973，，43： | 1 |
| 8 | Kinetics and mechanism of the oxidation of sulfur(IV) by ozone in aqueous solutions显示文摘 | Cornelus F B Julius H Jacobus J P | 1994 | Atmospheric Environment1994，28，20： | 1 |
| 9 | 1H-MR Spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jacobus F Walter H Klaas N | 2006 | Radiology2006，240，3： | 1 |
| 10 | 1H-MR Spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jacobus F Walter H Klaas N | 2006 | Radiology2006，240，3： | 1 |
| 11 | The role of the MAP-Kinase superfamily in β-amyloid toxicity 显示文摘 | Jacobus H | 2001 | Metabolic brain disease2001，16，34： | 1 |
| 12 | Cellulose hydrolysis and cellulose adsorption after pretreatment d cellulose materials显示文摘 | JACOBUS P H VAN WYK | 1997 | Biotechnology Techniques1997，11，6： | 1 |
| 13 | Biotechnology and the Utilization of Biowaste as a Resource for Bioproduct Development显示文摘 | Jacobus P H van Wyk | | 0，，05： | 1 |
| 14 | Transient left ventricular apical ballooning in a community hospital in Germany显示文摘 | Klaus Hertting Korff Krause Tobias H?rle Sigrid Boczor Jacobus Reimers Karl-Heinz Kuck | 2005 | International Journal of Cardiology2005，，3： | 1 |
| 15 | Cellulose hydrolysis and cellulose adsorption after pretreatment of cellulose materials显示文摘 | Jacobus P H van Wyk | 1997 | Biotechnology Techniques1997，11，6： | 1 |
| 16 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 17 | Biotechnology and the utilization of biowaste as a resource for bioproduct development显示文摘 | Jacobus P H Van Wyk | 2001 | TREND in Biotechnology2001，5，19： | 1 |
| 18 | Cyclic and Static Laboratory Tests on Drammen Clay显示文摘 | AndersenK H Jacobus H P Stephen F B | 1980 | Journal of Geoteehnical Engineering Division1980，106，5： | 1 |
| 19 | Impact of high-risk classification by FISH:an eastern cooperative oncology group (ECOG) study E4A03显示文摘 | Jacobus S J Kumar S Uno H | 2011 | Br J Haematol2011，155，： | 1 |
| 20 | Cellulose hydrolysis and cellulose adsorption after pretreatment of cellulose materials 显示文摘 | Jacobus P H van Wyk | 1997 | Biotechnology Techniques1997，11，6： | 1 |
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