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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review显示文摘Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron glandulosum.Coleb(CG:Fam.Verbenaceae).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity potentials.Further,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our laboratory.In keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and obesity.Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential.Non—toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties.The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis. | Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh V Devkar AV Ramachandran | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 3 |
| 3 | Efficient inducible cre-recombinase activation in vascular endothelium 显示文摘 | CLAXTON S KOSTOUROU V JADEJA S | 2008 | Genesis2008，46，2： | 1 |
| 4 | Protein energy wasting in chronic kidney disease: An update with focus on nutritional interventions to improve outcomes 显示文摘 | Jadeja Y P Kher V | 2012 | Indian J Endocrinol Metab2012，16，2： | 1 |
| 5 | Altered hepatic inflammatory response in the offspring following prenatal LPS exposure显示文摘 | Surriga O Ortega A Jadeja V | 2009 | Immunol Lett2009，，1： | 1 |
| 6 | Infections caused by Pseudomonas aeruginosa显示文摘 | Bodey GP Bolivar R Fainstein V Jadeja L | | 0，，02： | 1 |
| 7 | Protein energy wasting in chronic kidney disease:An update with focus on nutritional interventions to improve outcomes显示文摘 | Jadeja YP Kher V | 2012 | Indian J Endocrinol Metab2012，16，2： | 1 |
| 8 | Plasma production and preliminary results From the ADITYA Upgrade tokamak显示文摘The Ohmically heated circular limiter tokamak ADITYA(R_0?=?75 cm, a?=?25 cm) has been upgraded to a tokamak named the ADITYA Upgrade(ADITYA-U) with an open divertor configuration with divertor plates. The main goal of ADITYA-U is to carry out dedicated experiments relevant for bigger fusion machines including ITER, such as the generation and control of runaway electrons, disruption prediction, and mitigation studies, along with an improvement in confinement with shaped plasma. The ADITYA tokamak was dismantled and the assembly of ADITYA-U was completed in March 2016. Integration of subsystems like data acquisition and remote operation along with plasma production and preliminary plasma characterization of ADITYA-U plasmas are presented in this paper. | r l tanna j ghosh harshita raj rohit kumar suman aich vaibhav ranjan k a jadeja k m patel s b bhatt k sathyanarayana p k chattopadhyay m n makwana k s shah c n gupta v k panchal praveenlal edappala bharat arambhadiya minsha shah vismay raulji m b chowdhuri s banerjee r manchanda d raju p k atrey umesh nagora j raval y s joisa k tahiliani s k jha m v gopalkrishana | 2018 | Plasma Science and Technology2018，20，7： | 0 |
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