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| 1 | Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability显示文摘Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration.The particle technology involves several approaches from the conventional size reduction processes to the newer,novel particle technologies that modify the solubility properties of the drugs and produce solid,powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms.This review highlights the solid particle technologies available for improving solubility,dissolution and bioavailability of drugs with poor aqueous solubility. | Prakash Khadka Jieun Ro Hyeongmin Kim Iksoo Kim Jeong Tae Kim Hyunil Kim Jae Min Cho Gyiae Yun Jaehwi Lee | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 15 |
| 2 | Thin films as an emerging platform for drug delivery显示文摘Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, selfadministrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies. | Sandeep Karki Hyeongmin Kim Seon-Jeong Na Dohyun Shin Kanghee Joa Jaehwi Lee | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 6 |
| 3 | Liposomal formulations for enhanced lymphatic drug delivery显示文摘The lymphatic system that extends throughout the whole body is one of useful targets for efficient drug delivery.The intestinal lymphatic drug delivery has been actively studied to date because administered drugs can avoid the first-pass metabolism in the liver,resulting in improvement of oral bioavailability.Drugs must be hydrophobic in order to be transported into the intestinal lymphatics because the lipid absorption mechanism in the intestine is involved in the lymphatic delivery.Therefore,various lipid-based drug carrier systems have been recently utilized to increase the transport of drug into the intestinal lymphatics.Lipidic molecules of the lipid-based drug delivery systems stimulate production of chylomicrons in the enterocytes,resulting in an increase in drug transport into lymphatic in the enterocytes.This review summarizes recently reported information on development of liposomal carriers for the intestinal lymphatic delivery and covers important determinants for successful lymphatic delivery. | Hyeongmin Kim Yeongseok Kim Jaehwi Lee | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，2： | 3 |
| 4 | Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems显示文摘The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system. | Kanghee Jo Hyeongmin Kim Prakash Khadka Taejun Jang Soo Jin Kim Seong-Ha Hwang Jaehwi Lee | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 2 |
| 5 | Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake显示文摘 | Se Eun Byeon Jaehwi Lee Eunji Lee Song Yi Lee Eock Kee Hong Young Eon Kim Jae Youl Cho | 2009 | Archives of Pharmacal Research2009，，11： | 1 |
| 6 | Functional activation of macrophages,monocytes and splenic lymphocytes by polysaccharide fraction from Tricholomamatsutake显示文摘 | Byeon Se Eun Lee Jaehwi Lee Eunji | 2009 | Archives of Pharmacal Research2009，32，11： | 1 |
| 7 | Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract显示文摘 | Woo Seok Yang Jaehwi Lee Tae Woong Kim Ji Hye Kim Sukchan Lee Man Hee Rhee Sungyoul Hong Jae Youl Cho | 2012 | Journal of Ethnopharmacology2012，，1： | 1 |
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