|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy显示文摘Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity.After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects.The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases. | Sang Bong Lee Jae-Eon Lee Sung Jin Cho Jungwook Chin Sang Kyoon Kim In-Kyu Lee Sang-Woo Lee Jaetae Lee Yong Hyun Jeon | 2019 | Nano-Micro Letters2019，11，2： | 3 |
| 2 | Clinical applications of SPECT / CT after first I‐131 ablation in patients with differentiated thyroid cancer显示文摘 | Shin Young Jeong Sang‐Woo Lee Hae Won Kim Bong‐Il Song Byeong‐Cheol Ahn Jaetae Lee | 2014 | Clin Endocrinol2014，，： | 1 |
| 3 | Extra-thoracic tumor burden but not thoracic tumor burden on 18 F-FDG PET/CT is an independent prognostic biomarker for extensive-disease small cell lung cancer显示文摘 | Jong-Ryool Oh Ji-Hyoung Seo Chae Moon Hong Shin Young Jeong Sang-Woo Lee Jaetae Lee Jung-Joon Min Ho-Chun Song Hee-Seung Bom Young-Chul Kim Byeong-Cheol Ahn | 2013 | Lung Cancer2013，，： | 1 |
| 4 | 分化型甲状腺癌患者残余甲状腺组织和癌组织内^131I的生物动力学:使用重组人促甲状腺激素和停用甲状腺激素的比较显示文摘【摘要】目的通过^131I治疗后全身显像和SPECT显像对分化型甲状腺癌(DTC)患者残余甲状腺组织(简称残甲)和癌组织内^131I的生物动力学进行研究,同时评价促甲状腺激素(TSH)对^131I动力学的影响。方法对57例进行^131I治疗(治疗剂量2.96—7.4GBq)的患者进行回顾性分析。 | 唐军 Chae Moon Hong Choon-Young Kim Seung Hyun Son Ji-hoon Jung Chang-Hee Lee Ju Hye Jeong Shin Young Jeong Sang- Woo Lee Jaetae Lee Byeong-Cheol Ahn | 2018 | 中华核医学与分子影像杂志2018，38，4： | 1 |
| 5 | Direct comparison of adenosine and adenosine 5' - triphosphate as pharmacologic stress agents in conjunction with T1 - 201 SPECT: Hemodynamic response, myocardial tracer uptake, and size of perfusion defects in the same subjects显示文摘 | Kyung Ah Chun Jaetae Lee Sang - Woo Lee | 2006 | J Nucl Med2006，13，5： | 1 |
| 6 | Intra me dullay fat necrosis of multiple bones associated with pancreatitis显示文摘 | Byeong C Ahn Jaetae L Kyung IS | 1998 | J Nul Mes1998，39，： | 1 |
| 7 | Prognostic value of whole-body metabolic tumour volume and total lesion glycolysis measured on 18 F-FDG PET/CT in patients with extranodal NK/T-cell lymphoma显示文摘 | Choon-Young Kim Chae Moon Hong Do-Hoon Kim Seung Hyun Son Shin Young Jeong Sang-Woo Lee Jaetae Lee Byeong-Cheol Ahn | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，9： | 1 |
| 8 | Curcumin in various cancers显示文摘 | Adeeb Shehzad Jaetae Lee Young Sup Lee | 2013 | BioFactors2013，，： | 1 |
| 9 | Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles显示文摘BACKGROUND Dermal papillae(DP)and outer root sheath(ORS)cells play important roles in hair growth and regeneration by regulating the activity of hair follicle(HF)cells.AIM To investigate the effects of human mesenchymal stem cell-derived extracellular vesicles(hMSC-EVs)on DP and ORS cells as well as HFs.EVs are known to regulate various cellular functions.However,the effects of hMSC-EVs on hair growth,particularly on human-derived HF cells(DP and ORS cells),and the possible mechanisms underlying these effects are unknown.METHODS hMSC-EVs were isolated and characterized using transmission electron microscopy,nanoparticle tracking analysis,western blotting,and flow cytometry.The activation of DP and ORS cells was analyzed using cellular proliferation,migration,western blotting,and real-time polymerase chain reaction.HF growth was evaluated ex vivo using human HFs.RESULTS Wnt3a is present in a class of hMSC-EVs and associated with the EV membrane.hMSC-EVs promote the proliferation of DP and ORS cells.Moreover,they translocateβ-catenin into the nucleus of DP cells by increasing the expression ofβ-catenin target transcription factors(Axin2,EP2 and LEF1)in DP cells.Treatment with hMSC-EVs also promoted the migration of ORS cells and enhanced the expression of keratin(K)differentiation markers(K6,K16,K17,and K75)in ORS cells.Furthermore,treatment with hMSC-EVs increases hair shaft elongation in cultured human HFs.CONCLUSION These findings suggest that hMSC-EVs are potential candidates for further preclinical and clinical studies on hair loss treatment. | Ramya Lakshmi Rajendran Prakash Gangadaran Mi Hee Kwack Ji Min Oh Chae Moon Hong Young KwanSung Jaetae Lee Byeong-Cheol Ahn | 2022 | World Journal of Stem Cells2022，14，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员