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| 1 | Diffusion weighted imaging in the liver显示文摘Diffusion weighted magnetic resonance imaging (DWI) is an imaging technique which provides tissue contrast by the measurement of diffusion properties of water molecules within tissues. Diffusion is expressed in an apparent diffusion coefficient (ADC), which reflects the diffusion properties unique to each type of tissue. DWI has been originally used in neuroradiology. More recently, DWI has increasingly been used in addition to conventional unenhanced and enhanced magnetic resonance imaging (MRI) in other parts of the body. The reason for this delay was a number of technical problems inherent to the technique, making DWI very sensitive to artifacts, which had to be overcome. With assessment of ADC values, DWI proved to be helpful in characterization of focal liver lesions. However, DWI should always be used in conjunction to conventional MRI since there is considerable overlap between ADC values of benign and malignant lesions. DWI is useful in the detection of hepatocellular carcinoma in the cirrhotic liver and detection of liver metastases in oncological patients. In addition, DWI is a promising tool in the prediction of tumor responsiveness to chemotherapy and the follow-up of oncological patients after treatment, as DWI may be capable of detecting recurrent disease earlier than conventional imaging.This review focuses on the most common applications of DWI in the liver. | Petra G Kele Eric J van der Jagt | 2010 | World Journal of Gastroenterology2010，16，13： | 48 |
| 2 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 3 | Anastomotic biliary strictures after liver transplantation: Causes and consequences显示文摘 | Robert C. Verdonk Carlijn I. Buis Robert J. Porte Eric J. van der Jagt Abraham J. Limburg Aad P. van den Berg Maarten J.H. Slooff Paul M.J.G. Peeters Koert P. de Jong Jan H. Kleibeuker Elizabeth B. Haagsma | 2006 | Liver Transpl2006，，5： | 2 |
| 4 | Comparison of proteases from chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum 显示文摘 | Vander Jagt DI Hunsaker LA and Campos NM | 1987 | Biochem Pharmacol1987，36，： | 1 |
| 5 | Synthesis and ant-HIV activity of 1,1 '-dideoxygossypol and related compounds显示文摘 | ROBERT E R LORRAINE M D JAGT V | 1995 | J Med Chem1995，38，13： | 1 |
| 6 | Systemic treatment with pulsed electromagnetic fields do not affect bone microarchitecture in osteoporotic rats显示文摘 | Van Der Jagt OP Van Der Linden JC Waarsing JH | 2012 | Int Orthop2012，36，7： | 1 |
| 7 | Impact of early surgery af ter aneurysmal subarachnoid haemorrhage 显示文摘 | Van der Jagt M Hasan D Dippel WJ | 2009 | Acta Neurologica Scandinavica2009，119，2： | 1 |
| 8 | Aberrant accumulation of fibulin 3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression 显示文摘 | Roybal CN Marmorstein LY Vander Jagt DL | 2005 | Invest OphthVis Sci2005，46，11： | 1 |
| 9 | Three portable tonometers,the TGDc-01 ,the ICARE and the Tonopen XL, compared with each other and with Goldmann applanation tonometry 显示文摘 | van der Jagt LH Jansonius NM | 2005 | Ophthal- mic Physiol Opt2005，25，5： | 1 |
| 10 | Methylglyoxalmetablism and diabetic complications: roles of aldose reductase, glyox- alas-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase显示文摘 | Vander Jagt D L Hunsaker L A | 2003 | Chem Bid Interact2003，，： | 1 |
| 11 | Unfocused extracorporeal shock waves induce anabolic effects in rat bone显示文摘 | Van der Jagt OP Piscaer TM Schaden W | 2011 | J Bone Joint Surg Am2011，93，1： | 1 |
| 12 | Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food erops 显示文摘 | NOTEBORN H P LOMMEN A van der JAGT R C | 2000 | J Biotechnol2000，77，1： | 1 |
| 13 | The influence of the inactivating agent on the antigen content of inactivated Newcasde disease vaccines assessed by the in vitro potency test显示文摘 | Jagt H J M Bekkers M L E van Bommel S A J T et o!1 | 2010 | Biologicals2010，38，： | 1 |
| 14 | Computer-assisted solid lung nodule 3D volumetry on CT: influence of scan mode and iterative reconstruction: a CT phantom study 显示文摘 | COENEN A HONDA O VAN DER JAGT E J | 2013 | Japanese Journal of Radiology2013，31，10： | 1 |
| 15 | Synthesis and anti-HIV activity of 1,1′-dideoxygossypol and related compounds显示文摘 | ROBERT E R LORRAINE M D JAGT V | 1995 | J Med Chem1995，38，13： | 1 |
| 16 | Methylglyoxal m etabolism and diabetic complications:roles of aldose reductase,glyoxalaseI,betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase显示文摘 | VANDER JAGT DL HUNSAKER LA | 2003 | Chem Biol Interact2003，1，143144： | 1 |
| 17 | Systemic treatment with pulsed electromagnetic fields do not affect bone mlcroar-chltecture in osteoporotlc rats 显示文摘 | Van der Jagt OP van der Linden JC Waarsing JH | 2012 | Int Orthop2012，36，7： | 1 |
| 18 | Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops显示文摘 | NOTEBORN H P LOMMEN A VANDER JAGT R C | 2000 | Journal of Biotechnology2000，77，： | 1 |
| 19 | Architectural configuration and microstructural properties of the sacral plexus: A diffusion tensor MRI and fiber tractography study显示文摘 | Pasquelle K.N. van der Jagt Pieter Dik Martijn Froeling Thomas C. Kwee Rutger A.J. Nievelstein Bennie ten Haken Alexander Leemans | 2012 | Neuroimage2012，，3： | 1 |
| 20 | Interventions for Intrauterine Resuscitation in Suspected Fetal Distress During Term Labor: A Systematic Re- view显示文摘 | Bullens LM van Runnard Heimel PJ van der Hour-van der Jagt MB | 2015 | Obstet GynecolSurv2015，70，8： | 1 |
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