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| 1 | Multifaceted nature of membrane microdomains in colorectal cancer显示文摘Membrane microdomains or lipid rafts are known to be highly dynamic and to act as selective signal transduction mediators that facilitate interactions between the cell's external and internal environments.Lipid rafts play an important mediating role in the biology of cancer:they have been found in almost all existing experimental cancer models,including colorectal cancer (CRC),and play key regulatory roles in cell migration,metastasis,cell survival and tumor progression.This paper explores the current state of knowledge in this field by highlighting some of the pioneering and recent lipid raft studies performed on different CRC cell lines and human tissue samples.From this literature review,it becomes clear that membrane microdomains appear to be implicated in all key intracellular signaling pathways for lipid metabolism,drug resistance,cell adhesion,cell death,cell proliferation and many other processes in CRC.All signal transduction pathways seem to originate directly from those peculiar lipid islands,thereby orchestrating the colon cancer cells' state and fate.As confirmed by recent animal and preclinical studies in different CRC models,continuing to unravel the structure and function of lipid rafts-including their associated complex signaling pathways-will likely bring us one step closer to better monitoring and treating of colon cancer patients. | Kristina A Jahn Filip Braet | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 2 | Phanerozoic crustal growth:U-Pb and Sr-Nd isotopic evidence from the granites in northeastern China显示文摘 | Jahn Bor ming Wilde S A | 2000 | Tectonophysics2000，328，： | 1 |
| 3 | Model structure of the immunodominant surface antigen of Eimeria tenella identified as a target for sporozoite-neutralizing monoclonal antibody显示文摘 | Jahn D Matros A Anastasia Y | 2009 | Parasitol Res2009，105，： | 1 |
| 4 | Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence 显示文摘 | Jahn B Koch A Schmidt A | 1997 | Infect Immun1997，65，12： | 1 |
| 5 | Two contrasting Paleozoic magmatic belts in northern Inner Mongolia,China:petrogenesis and tectonic implications显示文摘 | Chen Bin Jahn Bor-ming Wilde S A | 2000 | Tectonophysics2000，328，： | 1 |
| 6 | Generalized contingent epiderivatives in set-valued op tnnization:optimality conditions显示文摘 | Jahn J Khan A A | 2002 | Numberical Functional Analysis and Optimization2002，23，78： | 1 |
| 7 | Two-and three-dimensional ray tracing applied to the land mobile satellite(LMS) progagtion channel显示文摘 | Dottling M Jahn A Didascalou D | 2001 | Antennas and Propagation Magazine2001，43，6： | 1 |
| 8 | Use of support vector machines for dis- ease risk prediction in genome - wide association studies : Concerns and opportunities显示文摘 | Mittag F Saad M Jahn A | 2012 | Human Mutation2012，33，12： | 1 |
| 9 | A new gene, Nytor, for hypersensitivity to Potato virus Y from Solarium tuberosum maps to chromosome IV显示文摘 | Celebi-Toprak F Slack S A Jahn M M | 2002 | Theoretical and Applied Genetics2002，104，： | 1 |
| 10 | Defensin alpha 6 (DEFA 6)overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients显示文摘 | RADEVA M Y JAHNS E WILHELM A | 2010 | BMC Cancer2010，2710，： | 1 |
| 11 | Highly fractionated I-type granites in NE China(I):Gechronology and petrogenesis显示文摘 | Wu F Y Jahn B M Wilde S A | 2003 | Lithos2003，66，3： | 1 |
| 12 | Microfluidic directed formation of liposomes of controlled size显示文摘 | Jahn A Vreeland N W DeVoe D L | 2007 | Langmuir2007，23，11： | 1 |
| 13 | The Lagrange multiplier rule in set-valued optimization显示文摘 | Gotz A Jahn J | 1999 | SIAM J Optim1999，10，2： | 1 |
| 14 | Graph kernels for chemical compounds using topological and three dimensional local atom pair environments显示文摘 | Hinselmann G Fechner N Jahn A | 2010 | Neurocomputing2010，74，1： | 1 |
| 15 | Fault tolerant three-phase AC motor drive topologies: A comparison of features, cost, and limitations显示文摘 | Welchko B A Lipo T A Jahns T M | 2004 | IEEE Transactions Power Electronics2004，19，4： | 1 |
| 16 | Six-phase voltage source inverter driven induction motor显示文摘 | Abbas M A Christen R Jahns T M | 1984 | IEEE Trans Ind Appl1984，20，5： | 1 |
| 17 | Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature 显示文摘 | LIU Z Q LIU J JAHN L A | 2009 | J Clin Endocr Metab2009，94，9： | 1 |
| 18 | Highly fractionated Ⅰ-type granites in NE China(Ⅱ): isotopic geochemistry and implications for crustal growth in the Phanerozoic显示文摘 | Wu F Y Borming Jahn Simon A Wilde | 2003 | Lithos2003，67，： | 1 |
| 19 | Microfluidic mixing and the formation of nanoscale lipid vesicles 显示文摘 | Jahn A Stavis SM Hong JS | 2010 | ACS Nano2010，4，： | 1 |
| 20 | Insights intopolymer versus oligosaccharide synthesis: mutagenesis and mechanisticstudies of a novel levansucrase from Bacillus megaterium 显示文摘 | Homann A Biedendieck R Gotze S Jahn D Seibel J | 2007 | Biochem J2007，407，： | 1 |
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