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| 1 | Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives显示文摘Objective:To synthesis 2-substituted-4,5-diphenyl-N- alkyl imidazole derivatives,and evaluate their antibacterial activity.Methods:A mixture of benzil(10 mmol) and ammonium acetate(0.1 mol)(immediately fused) in glacial acetic acid(25 mL) was stirred at 80-100℃for 1 h under nitrogen atmosphere(to prevent incorporation of any atmospheric impurities and moisture). Substituted aldehydes(10 mmol) in glacial acetic acid(5 mL) was added drop-wise over a period of 15-20 min at the same temperature and stirred for another 4 h,the progress of the reaction was monitored by TLC test using ethyl acetate as eluent.The newly synthesized compounds were characterized by IR,1HNMR,13CNMR and by mass spectroscopy.Results:All the synthesized compounds were confirmed by spectroscopical techniques and evaluated for antimicrobial activity against Staphylococcus aureus(S.aurius),Bacilus subtilus(B.subtilus),and Escheria coli (E.coli).These compounds showed antibacterial activity(zone of inhibition) against S.aurius ranged from 3 mm to 9 mmin diameter,B.subtilus,4 -8 mm,and E.coli 5 -12 mm.Out of 2a-2e, only 2a and 2b showed some sort of activity but none of them had considerable activity compared with that of the standard.Conclusions:All the synthesized compounds show moderate activity against the tested bacteria S.aurius,B.subtilus,and E.coli.So,further structural modification is necessary to improve the antibacterial action of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives. | Abhishek K Jain V Ravichandran Madhvi Sisodiya RK Agrawal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 3 |
| 2 | Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy 显示文摘 | Jain RK | 2005 | Science2005，307，： | 1 |
| 3 | Normalization of tumor vasculature: An emerging con- cept in antiangiogcnic therapy 显示文摘 | Jain RK | 2005 | Science2005，307，5706： | 1 |
| 4 | Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor显示文摘 | JAIN RK SAFABAKHSH N SCKELL A | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 5 | Angiogenesis in cancer and other disease显示文摘 | Carmeliet P Jain RK | 2000 | Nature2000，407，6801： | 1 |
| 6 | Melasma in men: a clinical, aetiological and histological study 显示文摘 | Sarkar R Purl P Jain RK | 2010 | J Eur Acad Dermatol Venereol2010，24，7： | 1 |
| 7 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy 显示文摘 | Jain RK | 2005 | Science2005，307，5706： | 1 |
| 8 | Photodynamic therapy for cancer 显示文摘 | Dolmans DE Fukumura D Jain RK | 2003 | Nat Rev Cancer2003，3，5： | 1 |
| 9 | Angiogenesis in cancer and other disease显示文摘 | Carmeliet P Jain RK | 2000 | Nature2000，407，： | 1 |
| 10 | Role of eNOS in neovascularization : NO for endothelial progenitor cells显示文摘 | Duda DG Fukumura D Jain RK | 2004 | Trends Mol Med2004，10，： | 1 |
| 11 | The role of nitric oxide in tumour progression显示文摘 | Fukumura D Kashiwagi S Jain RK | 2006 | Nat Rev Cancer2006，6，7： | 1 |
| 12 | Molecular mechanisms and clinical applica tions of angiogenesis显示文摘 | Carmeliet P Jain RK | 2011 | Nature2011，473，7347： | 1 |
| 13 | Normalization of tumor vasculature:an emerging concept in autiangiogenic therapy 显示文摘 | Jain RK | 2005 | Science2005，307，5706： | 1 |
| 14 | Molecular mechanisms and clinical applications of angiogenesis显示文摘 | Carmeliet P Jain RK | 2011 | Nature2011，473，7347： | 1 |
| 15 | Principles and mechanisms of vessel nor- malization for cancer and other angiogenic diseases 显示文摘 | Carmeliet P Jain RK | 2011 | Nat Rev Drug Diseov2011，10，6： | 1 |
| 16 | Angiogenesis in cancer and other diseases 显示文摘 | Carmeliet P Jain RK | 2000 | Nature2000，407，6801： | 1 |
| 17 | Molecular mechanisms and clini- cal applications of angiogenesis显示文摘 | Carmeliet P Jain RK | 2011 | Nature2011，473，： | 1 |
| 18 | Lessons from phase Ⅲ clinical trials on anti-VEGF therapy for cancer显示文摘 | Jain RK Duda DG Clark JW | 2006 | Nat Clin Pract Oncol2006，3，1： | 1 |
| 19 | Normalizing tumor vasculature with anti-angiogenic therapy:a new paradigm for combination therapy显示文摘 | Jain RK | 2001 | Nat Med2001，7，9： | 1 |
| 20 | Angiogenesis in cancer and other diseases显示文摘 | Carmeliet P Jain RK | 2000 | Nature2000，407，6801： | 1 |
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