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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Field scale interaction and nutrient exchange between surface water and shallow groundwater in the Baiyang Lake region,North China Plain显示文摘Fertilizer input for agricultural food production, as well as the discharge of domestic and industrial water pollutants, increases pressures on locally scarce and vulnerable water resources in the North China Plain. In order to:(a) understand pollutant exchange between surface water and groundwater,(b) quantify nutrient loadings, and(c) identify major nutrient removal pathways by using qualitative and quantitative methods, including the geochemical model PHREEQC) a one-year study at a wheat(Triticum aestivum L.) and maize(Zea mays L.) double cropping system in the Baiyang Lake area in Hebei Province, China, was undertaken. The study showed a high influence of low-quality surface water on the shallow aquifer. Major inflowing pollutants into the aquifer were ammonium and nitrate via inflow from the adjacent Fu River(up to 29.8 mg/L NH4-N and 6.8 mg/L NO3-N), as well as nitrate via vertical transport from the field surface(up to 134.8 mg/L NO3-N in soil water). Results from a conceptual model show an excess nitrogen input of about 320 kg/ha/a. Nevertheless,both nitrogen species were only detected at low concentrations in shallow groundwater,averaging at 3.6 mg/L NH4-N and 1.8 mg/L NO3-N. Measurement results supported by PHREEQC-modeling indicated cation exchange, denitrification, and anaerobic ammonium oxidation coupled with partial denitrification as major nitrogen removal pathways. Despite the current removal capacity, the excessive nitrogen fertilization may pose a future threat to groundwater quality. Surface water quality improvements are therefore recommended in conjunction with simultaneous monitoring of nitrate in the aquifer, and reduced agricultural N-inputs should be considered. | Bentje Brauns Poul L.Bjerg Xianfang Song Rasmus Jakobsen | 2016 | Journal of Environmental Sciences2016，28，7： | 6 |
| 3 | Techno-economic comparison of three technologies for precombustion CO2 capture from a lignite-fired IGCC显示文摘This paper compares the techno-economic performances of three technologies for CO2 capture from a lignite-based IGCC power plant located in the Czech Republic:(1)Physical absorption with a Rectisol-based process;(2)Polymeric CO2-selective membrane-based capture;(3)Low-temperature capture.The evaluations show that the IGCC plant with CO2 capture leads to costs of electricity between 91 and 120€·MWh−1,depending on the capture technology employed,compared to 65€·MWh−1 for the power plant without capture.This results in CO2 avoidance costs ranging from 42 to 84€·tCO2,avoided−1,mainly linked to the losses in net power output.From both energy and cost points of view,the low-temperature and Rectisol based CO2 capture processes are the most efficient capture technologies.Furthermore,partial CO2 capture appears as a good mean to ensure early implementation due to the limited increase in CO2 avoidance cost when considering partial capture.To go beyond the two specific CO2-selective membranes considered,a cost/membrane property map for CO2-selective membranes was developed.This map emphasise the need to develop high performance membrane to compete with solvent technology.Finally,the cost of the whole CCS chain was estimated at 54€·tCO2,avoided−1 once pipeline transport and storage are taken into consideration. | Simon Roussanaly Monika Vitvarova Rahul Anantharaman David Berstad Brede Hagen Jana Jakobsen Vaclav Novotny Geir Skaugen | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 3 |
| 4 | Different apoptotic reactions of dorsal root ganglion A- and B-cells after sciatic nerve axotomy: effect of p75 neurotrophin receptor显示文摘由不偏的 stereological 方法的背景,我们在神经损害以后在啮齿类动物观察了优先的背面的根中心( DRG )B房间损失,并且 caspase-3 激活和房间损失与受体( p75NTR ) .We 假设了的 p75 的礼品有关 pro-apoptotic 蛋白质的那 DRG B房间快速的高水平能被 p75NTR 的弄空作为与A房间和 pro-apoptotic 蛋白质的表情相比减少。试图识别 p75NTR 的这研究在神经 injury.Methods 以后在 DRG 神经原包含了 apoptotic 小径 p75NTB 大美人老鼠(p75-/-) 和 wildtype Balb/C 老鼠(p75+/+) 在这研究被使用。在 DRG 的 pro-apoptotic 蛋白质, c-Jun-N-terminal kinase (JNK ) , c-jun 和 p38 的表达式与 immunohistochemistry 被计算 2 和 7 天后面的单方的臀部的神经横断。另外,细胞外的相关 kinase (英皇家空军之阶级最低之兵),幸存信号的一个变换器,也在这些动物 models.Results Phosphorylated JNK ( P-JNK )和 phosphorylated p38 ( P-p38 )与 immunohistochemistry 和西方的弄污方法被测试主要位于小B房间,而 phosphorylated c-jun ( P-c-jun )位于A房间和B房间。Phosphorylated 英皇家空军之阶级最低之兵(津贴) 位于 B 房间和卫星房间。Axotomy 戏剧性地增加了 P-JNK 和 P-c-jun (配对的 t 测试) 的表情,没有对 P-p38 和津贴的表情的影响。而且,在 p75+/+ 老鼠的 P-JNK 的增加在神经 axotomy 以后的 2 天在 p75-/- 老鼠是近似那的 2.2 褶层(P=0.001,奇 t 测试).Conclusion p75NTR 依赖的 JNK-caspase-3 小径在神经损害以后涉及 DRG B 房间损失, JNK 不是唯一 c-jun 激活在上游。 | JIANG Yun Johannes Jakobsen | 2010 | Chinese Medical Journal2010，，19： | 2 |
| 5 | Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study显示文摘 | Lars Henrik Jensen Anders Aamann Rasmussen Lene Byriel Hidekazu Kuramochi Dorthe Gylling Crüger Jan Lindebjerg Peter V. Danenberg Anders Jakobsen Kathleen Danenberg | 2013 | Cellular Oncology2013，，5： | 2 |
| 6 | A correlation of optimal heat rejection pressures in transcritical carbon dioxide cycles显示文摘 | S.M Liao T.S Zhao A Jakobsen | 2000 | Applied Thermal Engineering2000，，9： | 2 |
| 7 | DNA polymorphism of HLA class II genes in primary biliary cirrhosis显示文摘 | Niels Morling Kim Dalhoff Lars Fugger J?rgen Georgsen Bodil Jakobsen Leo Ranek Niels ?dum Arne Svejgaard | 1992 | Immunogenetics1992，，2： | 2 |
| 8 | Resistance to first line platinum paclitaxel chemotherapy in serousepithelial ovarian cancer: The prediction value of ERCC1 and Tau expression显示文摘 | Karina Steffensen Marta Smoter Marianne Waldstr?m Bart?omiej Grala Lubomir Bodnar Rafa? Stec Cezary Szczylik Anders Jakobsen | 2014 | International Journal of Oncology2014，，5： | 2 |
| 9 | Environmental factors and risk of developing paediatric inflammatory bowel disease — A population based study 2007–2009显示文摘 | Christian Jakobsen Anders Paerregaard Pia Munkholm Vibeke Wewer | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 10 | Prognostic significance of p53, Her-2,and EGFR overexpression in borderline and epithelial ovarian cancer显示文摘 | Nielsen JS Jakobsen E Holund B | 2004 | Int J Gynecol Cancer2004，14，6： | 1 |
| 11 | Mycorrhizal fungi can dominate phosphate supply to plants irrespecrive of growth responses 显示文摘 | Smith SE Smith FA Jakobsen I | 2003 | Plant Physiology2003，133，： | 1 |
| 12 | Release of arsenic associated with the reduction and transformation of iron oxides 显示文摘 | Pedersen H D Postma D Jakobsen R | 2006 | Geochim Cosmochim Acta2006，70，： | 1 |
| 13 | MEGA2 :Molecular evolution-ary genetics analysissoftware 显示文摘 | KUMAR S TAMURA K JAKOBSEN I B | 2001 | Bioinformatics2001，17，： | 1 |
| 14 | Glutaraldehyde 'pure and impure' : A spectroscopic investigation of two commercial glutaraldehyde solutions and their reaction products with ami- no acids显示文摘 | Kirkegy S Jakobsen P Moe D | 1987 | Anal Lett1987，，20： | 1 |
| 15 | LNA-en-hanced detection of single nucleotide polymorphisms in the apolipoprotein E显示文摘 | JACOBSEN N BENTZEN J MELDGAARD M JAKOBSEN M H FENGER M KAUPPINEN S SKOUV J | 2002 | Nucleic Acids Res2002，30，19： | 1 |
| 16 | Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity 显示文摘 | Jakobsen A Nielsen JN Gyldenkerne N | 2005 | J Clin Oncol2005，23，7： | 1 |
| 17 | Improved infarction rates in fibroids after the introduction of contrast-enhanced ultrasound during uterine artery embolization显示文摘 | Dorenberg E J Hol PK Jakobsen J | 2012 | Acta Radiol2012，53，1： | 1 |
| 18 | Transcraniai Dopplerrecordings in raised intracranial pressure 显示文摘 | Hombui AM Jakobsen M Enevoldsen E | 1993 | Acta Neurol Scand1993，87，6： | 1 |
| 19 | MEGA2:Molecular evolutionary genetics analysis software显示文摘 | KUMAR S TAMARA K JAKOBSEN I B | 2001 | Bioinformatics2001，17，12： | 1 |
| 20 | Cyclone induced storm surge and flood forecasting in the northern bay of Bengal 显示文摘 | MADSEN H JAKOBSEN F | 2004 | Coastal Engineering2004，51，4： | 1 |
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