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| 1 | 利用ML振幅研究地壳横波Q值Ⅱ:Q横向变化特征显示文摘利用中国地震年报(1984-2004年)测定ML所用的54000余条区域地震最大振幅数据,采用二维层析成像方法反演中国大陆地壳介质品质因子Q0结构.反演结果表明,中国大陆地壳介质品质因子Q0平均为370,Q0横向变化量可达±200.在整个研究区解的分辨率能够达到3°×3°,大部分地区能够达到2°×2°.Q0的变化显示出与地质构造分区相关的特征:低衰减(高Q0值)异常区主要分布在塔里木盆地、四川盆地、鄂尔多斯高原及华南地区,鄂尔多斯高原北部Q0值最高;高衰减异常区(低Q0值)主要分布在青藏高原以东的川滇地区、华北平原、渤海湾,最低Q0值在渤海湾地区,天山、祁连山和汾渭地堑Q0也呈较低异常变化.总体看来,构造上稳定的克拉通地台的介质品质因子Q0较高,而构造上活动的地区往往Q0较低,显现出区域的衰减变化特征与地壳结构和区域构造之间的密切关系. | 汪素云 裴顺平 Thomas M. Heam 许忠淮 James F. Ni 俞言祥 | 2008 | 地球物理学报2008，51，1： | 30 |
| 2 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 3 | 卒中一级预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值显示文摘背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述,以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名,并经美国心脏协会(American HeartAssociation,AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法(涵盖时间为2006年上一次回顾发表到2009年4月),参考先前已发表的指南、个人文件和专家意见来总结现有证据,并指出现有知识的差距;如果合适,则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前,本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性(不可于预、可于预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种/种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) | 2010 | 国际脑血管病杂志2010，18，12： | 12 |
| 4 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 5 | Demographics, societal aging, and meat consumption in China显示文摘Drawn on the data collected by surveying 1 340 urban households from six cities in China, this paper estimates the impacts of demographic structure and population aging on household meat consumption, by jointly considering meat consumed at home and away from home. Based on the trajectories of population, a simple simulation on meat demand trend in China is conducted subsequently. The results suggest: 1) Meat consumed away from home averagely accounts for near 30% of household total meat consumption in terms of quantity, so that its omission likely leads to a significant underestimate of total meat consumption and misunderstanding the driving forces; 2) population aging significantly and negatively affects per capita meat consumption, suggesting that the expected meat demand in China without considering population aging will be overestimated. The findings from this study have important implications for better understanding the relative issues on China's meat consumption under the situation of population aging. | MIN Shi BAI Jun-fei James Seale Jr. Thomas Wahl | 2015 | Journal of Integrative Agriculture2015，14，6： | 11 |
| 6 | Multi-detector computed tomography in the diagnosis and management of acute aortic syndromes显示文摘Acute aortic syndrome(AAS) is a spectrum of conditions, which may ultimately progress to potentially life-threatening aortic rupture. This syndrome encompasses aortic dissection(AD), intramural haematoma, penetrating atherosclerotic ulcer and unstable thoracic aortic aneurysms. Multi-detector CT(MDCT) is crucial for the diagnosis of AAS, especially in the emergency setting due to its speed, accuracy and ready availability. This review attends to the value of appropriate imaging protocols in obtaining good quality images that can permit a confident diagnosis of AAS. AD is the most commonly encountered AAS and also the one with maximum potential to cause catastrophic outcome if not diagnosed and managed promptly. Hence, this review briefly addresses certain relevant clinical perspectives on this condition. Differentiating the false from the true lumen in AD is often essential; a spectrum of CT findings, e.g., 'beak sign', aortic 'cobwebs' that allows such differentiation have been described with explicit illustrations. The value of non enhanced CT scans, especially useful in the diagnosis of an intramural hematoma has also been illustrated. Overlap in the clinical and imaging features of the various conditions presenting as AAS is not unusual. However, on most instances MDCT enables the rightdiagnosis. On select occasions MRI or trans-esophageal echocardiography may be required as a problem solving tool. | James Thomas Patrick Decourcy Hallinan Gopinathan Anil | 2014 | World Journal of Radiology2014，6，6： | 11 |
| 7 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 8 | Biochar compost blends facilitate switchgrass growth in mine soils by reducing Cd and Zn bioavailability显示文摘Biochars have the potential to reclaim mine-impacted soils;however,their variable physico-chemical properties incite specu-lation about their successful remediation performance.This investigation examined the capability of biochars produced from three different feedstocks along with a compost blend to improve switchgrass growth conditions in a mine-impacted soil by examining influences on soil pH,grass metal contents,and soil-extractable metal concentrations.Cadmium(Cd)-and zinc(Zn)-contaminated mine soil was collected from a site near Webb City,Missouri,USA-a location within the Tri-State Min-ing District.In a full factorial design,soil was treated with a 0%,2.5%,and 5%(w/w)compost mixture(wood chips+beef cattle manure),and 0%,2.5%and 5%of each biochar pyrolyzed from beef cattle manure,poultry litter,and lodgepole pine feedstocks.Switchgrass(Panicum virgatum,‘Cave-In-Rock’variety)was grown in a greenhouse for 50 days and the mass of shoots(above-ground biomass)and roots was assessed,while soil pH,deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations were measured.Poultry litter biochar and compost had the greatest ability to raise soil pH(from 4.40 to 6.61),beef cattle manure biochar and compost moderately raised pH(from 4.4 to 5.92),and lodgepole pine biochar and compost weakly raised pH(from 4.40 to 5.05).Soils treated with beef cattle manure biochar,poultry litter biochar signifi-cantly reduced deionized H_(2)O-and 0.01 M CaCl_(2)-extractable Cd and Zn concentrations,while lodgepole pine biochar-treated soils showed mixed results.Switchgrass shoot and root masses were greatest in soil treated with compost in combination with either beef cattle manure biochar or poultry litter biochar.Soils treated with 5%beef cattle manure biochar+5%compost had greater reductions in total Cd and Zn concentrations measured in switchgrass shoots and roots compared to the other two treatments.The three biochars and compost mixtures applied to heavy metal,mine-impacted soil had considerable performance dissimilarities for improving switchgrass productivity.Switchgrass growth was noticeably improved after treatment with the compost in combination with biochar from beef cattle manure or poultry litter.This may be explained by the increased soil pH that promoted Zn and Cd precipitation and organic functional groups that reduced soil-available heavy metal concentrations.Our results imply that creating designer biochars is an important management component in developing successful mine-site phytostabilization programs. | Jeffrey M.Novak James A.Ippolito Donald W.Watts Gilbert C.Sigua Thomas F.Ducey Mark G.Johnson | 2019 | Biochar2019，1，1： | 8 |
| 9 | 青少年运动缺乏症(EDD)研究的10大问题显示文摘运动缺乏症(EDD)是一种儿科疾病,特点是中高强度体力活动(MVPA)下降,低于目前的推荐量,也与积极的健康结果不一致。目前,大多数儿童和青少年符合EDD的诊断标准,因为他们没有达到日常MVPA的最低要求。本文的目的是强调10个与青少年EDD有关的重要研究问题。需要进行重要的研究来更好地定义EDD的临床表现,包括评估体力活动行为以确定开始出现EDD的年龄或发育阶段;包括运动技巧和体能的运动起源(kinesiogenesis)的检测;以及对影响青少年MVPA的生活方式因素的评估。关于治疗EDD的干预措施和政策的研究问题,包括评估对卫生保健从业者进行运动医学重要性的教育和训练;确定在临床上识别和治疗EDD青少年的方法的有效性;开发敏感的、特效的、经济的方法以诊断青少年EDD;以及定制方法以促进本病诊疗的医疗保险赔付。如果未来研究不能优化EDD青少年的识别、治疗和管理方案,具有重大影响的生物医学、心理、经济和政治的新的卫生保健问题将会不断出现。 | Avery D. Faigenbam Thomas M. Best James MacDonald Gregory D. Myer Andrea Stracciolini | 2015 | 北京体育大学学报2015，38，11： | 8 |
| 10 | Velocity structure of uppermost mantle beneath China continent from Pn tomography显示文摘 | 汪素云 Thomas Hearn 许忠淮 James Ni 俞言祥 张晓东 | 2002 | Science China Earth Sciences2002，45，2： | 8 |
| 11 | 小型飞行器空气动力学显示文摘对小型飞行器设计中涉及的空气动力学问题进行了综述。描述了雷诺数和展弦比对固定翼飞行器的设计以及飞行性能的影响。在低雷诺数飞行范围。翼型上边界层的特性对飞行器的设计尤为关键。本文讨论了大量有关层流边界层(包括层流分离泡影响)的实验,作为例子,列举了几个此飞行雷诺数范围的小型低空无人驾驶飞行器(UAVs)。此外,对扑动翼推进的理论模型进行了简述;其范围涵盖了早期的准定常附着流模型,以及后来计及非定常尾涡、流动分离以及气动弹性等效应的模型。文中还介绍了那些与理论互补并最终导致扑翼机设计成功的实验。 | Thomas J.Muller nd.edu James D.Delaurier utias.utoronto.ca 于鑫 孙茂 | 2004 | 力学进展2004，34，2： | 8 |
| 12 | 基因组分析揭示番茄育种的历史显示文摘番茄(Solanum lycopersicum)适应性广,产量高,营养丰富,风味独特,栽培方式多样,是世界范围内广泛种植的第一大蔬菜作物。2012年全球产量达到1.62亿吨(联合国粮农组织(FAO)统计),产值超过550亿美元。番茄也是植物遗传、发育和生理研究的重要模式系统。番茄起源于南美洲的安第斯山脉,随着人类迁移和驯化逐渐传到中美洲和墨西哥一代,16世纪传到欧洲,在随后的几百年中番茄被传播到世界各地,在这一过程中受到不同的人工选择,产生了丰富的变异类型。番茄果实大小的变化是驯化的一个重要特征,今天人们食用的大果栽培番茄是由野生醋栗番茄(Solanum pimpinellifolium)驯化而来,野生番茄果实非常小,只有1~2g 重,经过人工的长期驯化,现代栽培番茄的果重是其祖先的100多倍。然而,番茄果实变大的人工驯化过程一直未有全面的研究,人类选择如何改变番茄基因组仍是知之甚少。 | 林涛 祝光涛 张俊红 许向阳 余庆辉 郑铮 张忠华 伦尧尧 李帅 王孝宣 黄泽军 李君明 张春芝 王涛涛 张余洋 王傲雪 张艳聪 林魁 李传友 熊国胜 薛勇彪 Andrea Mazzucato Mathilde Causse Zhangjun Fei James J.Giovannoni Roger T.Chetelat Dani Zamir Thomas Stadler 李景富 叶志彪 杜永臣 黄三文 | 2014 | 遗传2014，36，12： | 7 |
| 13 | 青藏高原东部的Pn波层析成像研究显示文摘利用INDEPTH/ASCENT台阵和其它布设在青藏高原的流动宽频带地震仪数据,反演了青藏高原东部和周边区域的上地幔顶层Pn波速度以及台站延迟.研究区域的平均Pn波速度是8.1km/s,略高于中国大陆的平均Pn波速度.低速区主要分布在羌塘地块的西部和松潘—甘孜地块,高温异常的岩石圈上地幔很可能是导致这一低速区的原因.班公-怒江缝合带东端区域的Pn波速度达到8.35km/s,这一高速区可能与向北俯冲的印度板块(东端)有关.另一Pn波高速区分布在祁连山和昆仑山之间,主要由柴达木盆地和共和盆地及其周边地区,两个并不完全连续的高速异常区组成,它可能对应于特提斯洋闭合时北部增生的克拉通地体;在后来的欧亚板块与印度板块的碰撞中,这一地体有可能阻挡了青藏高原向北的生长.相对密集的台站提供了高分辨率的速度结构横向分布和地壳厚度变化.台站延迟显示青藏高原北部和东部的地壳存在显著的减薄——松潘—甘孜地块东北缘的地壳厚度仅为约50km,而羌塘地块东部唐古拉山地壳最厚,达到75km,这可能是由于印度—欧亚板块碰撞引起的羌塘地块内部变形增厚所致. | 王海洋 Thomas HEARN 陈永顺 裴顺平 冯永革 岳汉 金戈 周仕勇 王彦宾 盖增喜 宁杰远 Eric Sandvol James NI | 2013 | 地球物理学报2013，56，2： | 6 |
| 14 | Clinical outcome of pediatric collagenous gastritis: Case series and review of literature显示文摘Collagenous gastritis (CG) is characterized by patchy subepithelial collagen bands. Effective treatment and the clinical and histological outcome of CG in children are poorly defined. The aim of this study is to summarize the published literature on the clinical outcome and response to therapy of pediatric CG including two new cases. We performed a search in Pubmed, OVID for related terms; articles including management and clinical and/or endo-histologic follow up information were included and abstracted. Reported findings were pooled in a dedicated database including the corresponding data extracted from chart review in our patients with CG. Twenty-four patients were included (17 females) with a mean age of 11.7 years. The clinical presentation included iron deficiency anemia and dyspepsia. The reported duration of follow up (in 18 patients) ranged between 0.2-14 years. Despite most subjects presenting with anemia including one requiring blood transfusion, oral iron therapy was only documented in 12 patients. Other treatment modalities were antisecretory measures in 13 patients; proton pump inhibitors (12), or histamine-2 blockers (3), sucralfate (5), prednisolone (6), oral budesonide in 3 patients where one received it in fish oil and triple therapy (3). Three (13%) patients showed no clinical improvement despite therapy; conversely 19 out of 22 were reported with improved symptoms including 8 with complete symptom resolution. Spontaneous clinical resolution without antisecretory, anti-inflammatory or gastroprotective agents was noted in 5 patients (4 received only supplemental iron). Follow up endohistopathologic data (17 patients) included persistent collagen band and stable Mononuclear cell infiltrate in 12 patients with histopathologic improvement in 5 patients. Neither collagen band thickness nor mononuclear cell infiltrate correlated with clinical course. Intestinal metaplasia and endocrine cell hyperplasia were reported (1) raising the concern of long term malignant transformation. In summary, CG in children is a chronic disease, typically with a variable clinical response and an indolent course that is distinct from the adult phenotype. Long term therapy usually inclused iron supplementation but cannot be standardized, given the chronicity of the disease, variability of response and potential for adverse events. | Nadia Mazen Hijaz Seth Steven Septer James Degaetano Thomas Mario Attard | 2013 | World Journal of Gastroenterology2013，19，9： | 5 |
| 15 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)显示文摘 | Nuh N. Rahbari O. James Garden Robert Padbury Mark Brooke-Smith Michael Crawford Rene Adam Moritz Koch Masatoshi Makuuchi Ronald P. Dematteo Christopher Christophi Simon Banting Val Usatoff Masato Nagino Guy Maddern Thomas J. Hugh Jean-Nicolas Vauthey Pau | 2011 | Surgery2011，，5： | 4 |
| 16 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 17 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 18 | Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)显示文摘 | James D. Cox JoAnn Stetz Thomas F. Pajak | 1995 | International Journal of Radiation Oncology, Biology, Physics1995，，5： | 4 |
| 19 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 20 | Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma显示文摘 | Hashem B. El-serag Thomas Tran James E. Everhart | 2004 | Gastroenterology2004，，2： | 3 |
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