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| 1 | Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma显示文摘AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients. | Bing Xia Le Zhang Shan-Qi Guo Xiao-Wu Li Fu-Lian Qu Hai-Feng Zhao Lian-Yu Zhang Bao-Cun Sun James You Yi-Zhuo Zhang | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 2 | The impact of fluorination on both donor polymer and non-fullerene acceptor:The more fluorine,the merrier显示文摘Fluorination of the donor polymer or non-fullerene acceptor (NFA) in an organic photovoltaic device is an effective method to improve device efficiency.Although there have been many studies on donor polymer fluorination,blends containing both a fluorinated donor and fluorinated NFA have rarely been reported.In this study,we use two donor polymers (4'-FT-HTAZ and 4'-FT-FTAZ) and two NFAs (ITIC-Th and ITIC-Th1) with different amounts of fluorine (from 2F to 6F) to investigate how the degree of fluorination in a blend impacts device performance.We find that fluorinating the NFA leads to a higher short-circuit current density (Jsc) and fill factor (FF),however,the open-circuit voltage (Voc) is decreased due to a depressed lowest unoccupied molecular orbital (LUMO) level.Adding additional fluorine to the donor polymer does not have a large effect on the Jsc or FF,but it does lead to an improved Voc.By fluorinating the NFA and having more fluorine on the donor polymer,we obtain both a high Jsc and Voc simultaneously,leading to a power conversion efficiency over 10% in the case of 4'-FT-FTAZ:ITIC-Th1,which has the most amount of fluorine (6F). | Nicole Bauer Qianqian Zhang Jeromy James Rech Shuixing Dai Zhengxing Peng Harald Ade Jiayu Wang Xiaowei Zhan Wei You | 2019 | Nano Research2019，12，9： | 3 |
| 3 | Non-invasive detection of pancreatic cancer by measuring DNA methylation of Basonuclin 1 and Septin 9 in plasma显示文摘Pancreatic cancer (PC), a deadly malignancy with an overall 5-year survival rate of 5% to 15%, is ranked as the seventh leading cause of cancer death in the world in spite of its low occurrence rate.[1,2] Early detection appears to be the most effective approach to improve the overall survival of patients with PC. However, the difficulty in early detection of PC is a lack of specific symptoms and reliable biomarkers. Currently, carbohydrate antigen 19-9 (CA 19-9) is a serum biomarker that is widely used in PC detection. However, 10% of patients with PC cannot produce CA 19-9 and serum CA 19-9 is frequently absent in patients with early-stage cancer. Furthermore, CA 19-9 is often found to be elevated in benign conditions or in other cancers, making its utility limited. Therefore, it is important to identify new diagnostic biomarkers to improve PC detection. | Xiao-Bin Li Jun Ma Zi-Wen Liu Wen-Fei He Zong-Ze Li Ming Cui Huang Hao Guang-Peng Zhou Lei You James Wang Xiao-Liang Han Yu-Pei Zhao | 2019 | Chinese Medical Journal2019，，12： | 2 |
| 4 | Epidermal growth factor receptor and Ink4a/Arf显示文摘 | Robert M Bachoo Elizabeth A Maher Keith L Ligon Norman E Sharpless Suzanne S Chan Mingjian James You Yi Tang Jessica DeFrances Elizabeth Stover Ralph Weissleder David H Rowitch David N Louis Ronald A DePinho | 2002 | Cancer Cell2002，，3： | 1 |
| 5 | Scattering-Model-Based Methods for TOA Location in NLOS Environments 显示文摘 | Saleh AI-Jazzar James Caffery Jr Heung-Ryeol You | 2007 | IEEE Transactions on vehicular technology2007，56，2： | 1 |
| 6 | Plasticity of mycangia in Xylosandrus ambrosia beetles显示文摘Insects that depend on microbial mutualists evolved a variety of organs to transport the microsymbionts while dispersing. The ontogeny and variability of such organs is rarely studied, and the microsymbiont*s effects on the animal tissue development remain unknown in most cases. Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae or Platypodinae) and their mutualistic fungi are an ideal system to study the animalfungus interactions. While the interspecific diversity of their fungus transport organ一 mycangia—is well-known, their developmental plasticity has been poorly described. To determine the ontogeny of the mycangium and the influence of the symbiotic fungus on the tissue development, we dissected by hand or scanned with micro-CT the mycangia in various developmental stages in five Xylosandrus ambrosia beetle species that possess a large, mesonotal mycangium: Xylosandrus amputatus. Xylosandrus compactus, Xylosandrus crassiusculus, Xylosandrus discolor, and Xylosandrus germanus. We processed 181 beetle samples from the United States and China. All five species displayed three stages of the mycangium development:(1) young teneral adults had an empty, deflated and cryptic mycangium without fungal mass;(2) in fully mature adults during dispersal, the promesonotal membrane was inflated, and most individuals developed a mycangium mostly filled with the symbiont, though size and symmetry varied;and (3) after successful establishment of their new galleries, most females discharged the bulk of the fun gal inoculum and deflated the mycangium. Experimental aposymbiotic individuals demonstrated that the pronotal membrane invaginated independently of the presence of the fungus, but the fungus was required for inflation. Mycangia are more dynamic than previously thought, and their morphological changes correspond to the phases of the symbiosis. Importantly, studies of the fungal symbionts or plant pathogen transmission in ambrosia beetles need to consider which developmental stage to sample. We provide illustrations of the different stages, including microphotography of dissections and micro-CT scans. | You Li Yong-Ying Ruan Edward L. Stanley James Skelton Jiri Hulcr | 2019 | Insect Science2019，26，4： | 1 |
| 7 | 四生散对肺癌细胞增殖的抑制作用及毒性研究显示文摘主要探讨中药制剂四生散对人肺癌A5 4 9细胞株的增殖抑制作用以及其急性毒性.应用改进的MTT法测定四生散对肺癌细胞增殖的影响;采用琼脂糖凝胶电泳测定四生散对诱导肿瘤细胞凋亡的影响;再用分剂量组灌胃小鼠的方法,鉴定四生散的急性毒性.实验结果表明,四生散对人肺癌A5 4 9细胞株的增殖有较强的抑制作用,并具有明显的量效和时效相关性;经四生散处理后的A5 4 9细胞呈现凋亡特征性电泳条带;在3 2倍于人的剂量时,小鼠饮食和体重均在正常水平,并无异常,证实口服四生散无急性毒性. | 陈黎黎 陈智樑 陈峰 M. James You 陈灵 | 2011 | 复旦学报(自然科学版)2011，50，3： | 1 |
| 8 | Experiments on anisotropic etching of Si in TMAH显示文摘 | Jae Sung You Donghwan Kim Joo Youl Huh Ho Joon Park James Jungho Pak Choon Sik Kang | 2001 | Solar Energy Materials and Solar Cells2001，，1： | 1 |
| 9 | Primary structure of Beijing duck apolipoprotein A-1显示文摘 | Zi-Wei Gu Yong-Hong Xie Manlan Yang James T. Sparrow Keqin Wang You Li Wen-Hsiung Li Antonio M. Gotto Chao-Yuh Yang | 1993 | Journal of Protein Chemistry1993，，5： | 1 |
| 10 | Design and mechanical properties of a novel cerebral flow diverter stent显示文摘 | Ma Jiayao You Zhong James Byrne | 2014 | Annals of Biomedical Engineering2014，42，10： | 1 |
| 11 | Hemodynamic effects of the vacuum-assisted closure device on open mediastinal wounds 1显示文摘 | Anne M Conquest James H Garofalo David M Maziarz Kim G Mendelson You Su Sun William A Wooden William M Meadows Wiley Nifong W.Randolph Chitwood | 2003 | Journal of Surgical Research2003，，2： | 1 |
| 12 | Static output feedback stabilization: an ILMI approach显示文摘 | Cao Y Y James L A M You X S | 1998 | Automatica1998，34，12： | 1 |
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