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| 1 | Lymph node metastases of adenocarcinoma of the esophagus and esophagogastric junction显示文摘背景食道的腺癌正在成为日益重要的 problem.It 大多数很快在最后十年在西方的国家一直在增加恶意,并且它的预后是这研究的 poor.The 目的是为食管和 esophagogastric 连接的腺癌评估在肿瘤侵略深度和淋巴节点转移之间的关系,并且学习组与 aden 包括了 121 个病人在 patients.Methods | ZHANG Xun David I Watson Glyn G Jamieson | 2007 | Chinese Medical Journal2007，，24： | 7 |
| 2 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 3 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 4 | 甲醛固定石蜡包埋组织中DNA的降解情况显示文摘 | 田子强 刘俊峰 王贵英 Eric Smith Paul Drew David Watson Glyn G Jamieson | 2004 | 中华病理学杂志2004，33，3： | 4 |
| 5 | 环境主义的核心显示文摘如果试图问什么是环境主义,可能会有许多不同的回答。本文通过对环境主义的考察,提出正义在概念上和历史上都是环境主义的核心,应当用环境正义的原则处理人与自然的关系。 | Dale Jamieson 王小文 | 2005 | 南京林业大学学报(人文社会科学版)2005，5，1： | 4 |
| 6 | Adult duodenal intussusception associated with congenital malrotation显示文摘Enteroenteric intussusception is a condition in which full-thickness bowel wall becomes telescoped into the lumen of distal bowel. In adults, there is usually an abnormality acting as a lead point, usually a Meckels' diverticulum, a hamartoma or a tumour. Duodeno-duodenal intussusception is exceptionally rare because the retroperitoneal situation fixes the duodenal wall. The aim of this report is to describe the first published case of this condition. A patient with duodeno-duodenal intussusception secondary to an ampullary lesion is reported. A 66 year-old lady presented with intermittent abdominal pain, weight loss and anaemia. Ultrasound scanning showed dilated bile and pancreatic ducts. CT scanning revealed intussusception involving the full-thickness duodenal wall. The lead point was an ampullary villous adenoma. Congenital partial (type Ⅱ) malrotation was found at operation and this abnormality permitted excessive mobility of the duodenal wall such that intussusception was possible. This condition can be diagnosed using enhanced CT. Intussusception can be complicated by bowel obstruction, ischaemia or bleeding, and therefore the underlying cause should be treated as soon as possible. | J Gardner-Thorpe RH Hardwick NR Carroll P Gibbs NV Jamieson RK Praseedom | 2007 | World Journal of Gastroenterology2007，13，28： | 3 |
| 7 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 8 | Endoscopic Ultrasound-guided drainage of an abdominal fluid collection following Whipple's resection显示文摘Percutaneous aspiration and drainage of post-operative abdominal fluid collections is a well established standard technique. However,some fluid collections are not amenable to percutaneous drainage either due to location or the presence of surrounding visceral structures. Endoscopic Ultrasound (EUS) has been widely used for the drainage of pancreatitis-related abdominal fluid collections. However,there are no reports on the use of this technique in the post-operative setting. We report a case where the EUS-guided technique was used to drain a percutaneously inaccessible post-operative collection which had developed after Whipple's resection. | Asif Jah Neville Jamieson Emmanuel Huguet William Griffi ths Nicholas Carroll Raaj Praseedom | 2008 | World Journal of Gastroenterology2008，14，44： | 3 |
| 9 | Chronic myeloid leukemia: mechanisms of blastic transformation显示文摘 | Perrotti Danilo Jamieson Catriona Goldman John Skorski Tomasz | 2010 | Journal of Clinical Investigation2010，，7： | 3 |
| 10 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 11 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 12 | 肺动脉内膜剥脱术治疗慢性栓塞性肺动脉高压——UCSD32例手术经验显示文摘目的 分析肺动脉内膜剥脱术(PEA)治疗慢性栓塞性肺动脉高压的围手术期资料,探讨美国加州大学圣迭戈分校(UCSD)手术经验.方法 回顾性研究UCSD 32例肺动脉血栓内膜剥脱手术资料,其中男17例,女15例;平均年龄(47.56±16.04)岁,平均病程(3.90±4.61)年;15例有深静脉血栓病史.采用全麻、胸骨正中切口、深低温、间断停循环双侧肺动脉内膜剥脱的手术方法.结果 根据术中病理标本Jamieson分型,Ⅰ型占21.8%,Ⅱ型占28.1%,Ⅲ型占37.5%.平均转机(236.32±37.27)min,主动脉阻断(111.69±28.14)min,停循环(38.00±13.58)min.术后机械通气(66.23±99.24)h,住ICU(4.62±4.50)天,无死亡.病人肺动脉收缩压由术前(81.03±16.92)mm Hg(1 mm Hg=0.133 kPa)降至术后(51.20±12.16)mm Hg,肺血管阻力由术前(88.91±42.32)kPa·s·L-1降至术后的(34.38±15.68)kPa·s·L-1,心排量由术前(3.65±1.08)L/min增加到术后(5.85±1.21)L/min,中心静脉压由(13.07±2.11)cmH2O(1 cmH2O=0.098 kPa)降至(9.86±3.02)cmH2O.术后短期随访显示,病人心功能(NYHA)恢复到Ⅰ级19例、Ⅱ级13例,生活质量明显改善.结论 PEA是治疗慢性栓塞性肺动脉高压的重要手段,手术成功率逐年提高;深低温、间断停循环、双侧肺动脉内膜剥脱及内膜外翻技术为PEA标准术式.多中心资料证实该术式可以有效降低肺动脉压和肺血管阻力,明显改善血流动力学指标和心肺功能.多数国内医疗中心没有足够手术经验,应尽量避免选择肺动脉压收缩≥100mmHg,肺血管阻力≥100kPa·s·L^-1及Ⅲ型病变者行PEA手术. | 顾松 刘岩 苏丕雄 翟振国 杨媛华 王辰 Michael M. Madani Stuart W. Jamieson | 2010 | 中华胸心血管外科杂志2010，26，4： | 2 |
| 13 | Fundamental electronic structure and multiatomic bonding in 13 biocompatible high-entropy alloys显示文摘High-entropy alloys(HEAs)have attracted great attention due to their many unique properties and potential applications.The nature of interatomic interactions in this unique class of complex multicomponent alloys is not fully developed or understood.We report a theoretical modeling technique to enable in-depth analysis of their electronic structures and interatomic bonding,and predict HEA properties based on the use of the quantum mechanical metrics,the total bond order density(TBOD)and the partial bond order density(PBOD).Application to 13 biocompatible multicomponent HEAs yields many new and insightful results,including the inadequacy of using the valence electron count,quantification of large lattice distortion,validation of mechanical properties with experiment data,modeling porosity to reduce Young’s modulus.This work outlines a road map for the rational design of HEAs for biomedical applications. | Wai-Yim Ching Saro San Jamieson Brechtl Ridwan Sakidja Miqin Zhang Peter K.Liaw | 2020 | npj Computational Materials2020，，1： | 2 |
| 14 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 15 | CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis显示文摘 | Siddhartha Jaiswal Catriona H.M. Jamieson Wendy W. Pang Christopher Y. Park Mark P. Chao Ravindra Majeti David Traver Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 16 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 17 | Diffraction Limited Infrared Zoom Collimator 显示文摘 | Thomas H Jamieson | 1997 | Proceedings of SPIE1997，3129，： | 2 |
| 18 | Severe 2009 H 1 N1 influenza in pregnant and postpartum women in California显示文摘 | Louie JK Acosta M Jamieson D J | 2010 | N Engl J Med2010，362，1： | 1 |
| 19 | Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda显示文摘 | Gedeon A K Colley A Jamieson R | 1999 | Nat Genet1999，22，4： | 1 |
| 20 | Thermal effects in optical systems 显示文摘 | Jamieson T H | 1981 | Optical Engineering1981，20，2： | 1 |
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