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| 1 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Human IgG Fc receptor heterogeneity:molecular aspects and clinical implications 显示文摘 | Jan GJ van de Winkel JGJ Peter JA | 1993 | Immunnol Today1993，14，： | 1 |
| 3 | Measurement of rapidly available glucose (RAG) in plant foods: a potential in vitro predictor of the glycaemic response 显示文摘 | Englyst HN Veenstra Jan Hudson GJ | 1996 | Br J Nutg1996，75，： | 1 |
| 4 | A novel, possibly func- tional, single nucleotide polymorphism in the coding region of the thrombin-activatable fibfinolysis inhibitor (TAFI) gene is also associ- ated with TAFI levels 显示文摘 | Jan Brouwers GJ Vos HL Frank WG | 2001 | Blood2001，98，6： | 1 |
| 5 | Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways 显示文摘 | Braunstahl GJ Overbeek SE Klein Jan A | 2001 | J Allergy Clin Immunol2001，107，3： | 1 |
| 6 | Fc receptor and complement receptor-mediated phagocytosis in host defense显示文摘 | Gestur V Jan GJ | 1998 | Current Opinion in infectious Diseases1998，11，1： | 1 |
| 7 | Human IgG Fc receptor heterogenecity:molecular aspects and clinical implications显示文摘 | Jan GJ Van de Winkel JGJ Peter JA | 1993 | Immunnol Today1993，14，5： | 1 |
| 8 | Fc receptor and complement receptor-mediated phagocytosis in host defense显示文摘 | Gestur V Jan GJ | 1998 | Current Opinion in infectious Diseases1998，11，1： | 1 |
| 9 | Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia显示文摘 | Jean GJ Gordon S Jan M | 1996 | Human Gene Therapy1996，7，5： | 1 |
| 10 | Genetic influence on cytokine production and fatal meningococcal disease显示文摘 | Rudi GJ Westendorp Jan AM Langermans Tom WJ Huizinga Abdul H Elouali Cornelis L Verweij Dorret I Boomsma Jan P Vandenbrouke | 1997 | The Lancet1997，，9046： | 1 |
| 11 | Nasal aller-gen provocation induces adhesion molecule expression andtissue eosinophilia in upper and lower airways 显示文摘 | Braunstahl GJ Overbeek SE Klein Jan A | 2001 | Journal ofAllergy and Clinical Immunology2001，107，3： | 1 |
| 12 | Fcreceptor and complement receptor-mediated phago-cytosis in host defense显示文摘 | Gestur V Jan GJ | 1998 | Curr Opin Infect Dis1998，11，1： | 1 |
| 13 | Fereceptor and complement receptor mediated phago cytosis in host defense 显示文摘 | Gestur V Jan GJ | 1998 | Current Opinion in Infectious Diseases1998，11，1： | 1 |
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