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| 1 | Improving the outcomes in gastric cancer surgery显示文摘Gastric cancer remains a significant health problem worldwide and surgery is currently the only potentially curative treatment option. Gastric cancer surgery is generally considered to be high risk surgery and fiveyear survival rates are poor,therefore a continuous strive to improve outcomes for these patients is warranted. Fortunately,in the last decades several potential advances have been introduced that intervene at various stages of the treatment process. This review provides an overview of methods implemented in pre-,intra- and postoperative stage of gastric cancer surgery to improve outcome. Better preoperative risk assessment using comorbidity index(e.g.,Charlson comorbidity index),assessment of nutritional status(e.g.,short nutritional assessment questionnaire,nutritional risk screening- 2002) and frailty assessment(Groningen frailty indicator,Edmonton frail scale,Hopkins frailty) was introduced. Also preoperative optimization of patients using prehabilitation has future potential.Implementation of fast-track or enhanced recovery after surgery programs is showing promising results,although future studies have to determine what the exact optimal strategy is.Introduction of laparoscopic surgery has shown improvement of results as well as optimization of lymph node dissection.Hyperthermic intraperitoneal chemotherapy has not shown to be beneficial in peritoneal metastatic disease thus far.Advances in postoperative care include optimal timing of oral diet,which has been shown to reduce hospital stay.In general,hospital volume,i.e.,centralization,and clinical audits might further improve the outcome in gastric cancer surgery.In conclusion,progress has been made in improving the surgical treatment of gastric cancer.However,gastric cancer treatment is high risk surgery and many areas for future research remain. | Juul JW Tegels Michiel FG De Maat Karel WE Hulsewé Anton GM Hoofwijk Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，38： | 16 |
| 2 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 3 | Prospective comparison of the value of brushings before and after biopsy in the endoscopic diagnosis of gastroesophageal malignancy显示文摘 | Zargar SA Khuroo MS Jan GM | 1991 | Acta Cytol1991，35，5： | 1 |
| 4 | Ruptured heterotopic pregnancy: A rare cause for hemoperitoneum:report of three cases from Kashmir显示文摘 | Jan F Naikoo GM Rather MH | 2010 | Indian J Surg2010，72，5： | 1 |
| 5 | Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer显示文摘 | Yixin Wang Jan GM Klijn Yi Zhang Anieta M Sieuwerts Maxime P Look Fei Yang Dmitri Talantov Mieke Timmermans Marion E Meijer-van Gelder Jack Yu Tim Jatkoe Els MJJ Berns David Atkins John A Foekens | 2005 | The Lancet2005，，9460： | 1 |
| 6 | Early growth response-1 gene(Egr-1)promoter induction by ionizing radiation in U87 malignantglioma cells in vitro显示文摘 | Ralph GM Jan HK Reinhard K | 2002 | Eur J Biochem2002，269，1： | 1 |
| 7 | Contrast enhanced ultrasound (CEUS) in blunt abdominal trauma 显示文摘 | Cagini L Gm Jan'te S Malaspina CM | 2013 | Crit Ultrasound 32013，5，1： | 1 |
| 8 | Prospective comparison of the value of brushings before and after biopsy in the endoecoplc diagnosis of gastroesophageal malignancy显示文摘 | Zargar SA Khuroo MS Jan GM | 1991 | Acta Cytol1991，35，： | 1 |
| 9 | Developing a Core Set to Describe Functioning in Vocational Rehabilitation Using The International Classification of Functioning, Disability, and Health (ICF)显示文摘 | Reuben Escorpizo Jan Ekholm Hans-Peter Gmünder Alarcos Cieza Nenad Kostanjsek Gerold Stucki | 2010 | Journal of Occupational Rehabilitation2010，，4： | 1 |
| 10 | Pathway analysis of gene signatures predicting metastasis of node - negative primary breast cancer显示文摘 | Jack X Yu Anieta M Sieuwerts Yi Zhang John WM Martens Marcel Staid Jan GM Klijn Yixin Wang John A Foekens | 2007 | BMC Cancer2007，25，7： | 1 |
| 11 | Analysis of compressive fracture of three different concretes by means of 3D-digital image correlation and vacuum impregnation 显示文摘 | Daniel Caduff Jan GM Van Mier | | Cement Concrete Comp0，32，4： | 1 |
| 12 | Graft dilatation and Barrett’s esophagus in adults after gastric pullup and jejunal interposition for long-gap esophageal atresia显示文摘BACKGROUND Esophageal replacement(ER)with gastric pull-up(GPU)or jejunal interposition(JI)used to be the standard treatment for long-gap esophageal atresia(LGEA).Changes of the ER grafts on a macro-and microscopic level however,are unknown.AIM To evaluate long-term clinical symptoms and anatomical and mucosal changes in adolescents and adults after ER for LGEA.METHODS A cohort study was conducted including all LGEA patients≥16 years who had undergone GPU or JI between 1985-2003 at two tertiary referral centers in the Netherlands.Patients underwent clinical assessment,contrast study and endoscopy with biopsy.Data was collected prospectively.Group differences between JI and GPU patients,and associations between different outcome measures were assessed using the Fisher’s exact test for bivariate variables and the Mann-Whitney U-test for continuous variables.Differences with a P-value<0.05 were considered statistically significant.RESULTS Nine GPU patients and eleven JI patients were included.Median age at follow-up was 21.5 years and 24.4 years,respectively.Reflux was reported in six GPU patients(67%)vs four JI patients(36%)(P=0.37).Dysphagia symptoms were reported in 64%of JI patients,compared to 22%of GPU patients(P=0.09).Contrast studies showed dilatation of the jejunal graft in six patients(55%)and graft lengthening in four of these six patients.Endoscopy revealed columnar-lined esophagus in three GPU patients(33%)and intestinal metaplasia was histologically confirmed in two patients(22%).No association was found between reflux symptoms and macroscopic anomalies or intestinal metaplasia.Three GPU patients(33%)experienced severe feeding problems vs none in the JI group.The median body mass index of JI patients was 20.9 kg/m^(2) vs 19.5 kg/m^(2) in GPU patients(P=0.08).CONCLUSION The majority of GPU patients had reflux and intestinal metaplasia in 22%.The majority of JI patients had dysphagia and a dilated graft.Follow-up after ER for LGEA is essential. | Eleonora Sofie van Tuyll van Serooskerken Gabriele Gallo Bas L Weusten Jessie Westerhof Lodewijk AA Brosens Sander Zwaveling Jetske Ruiterkamp Jan BF Hulscher Hubertus GM Arets Arnold JN Bittermann David C van der Zee Stefaan HAJ Tytgat Maud YA Lindeboom | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，9： | 0 |
| 13 | Similar fecal immunochemical test results in screening and referral colorectal cancer显示文摘AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION: Differences in T stage distribution largely explain differences in FIT results between screening and referral cohorts. Therefore, FIT results should be reported according to T stage. | Sietze T van Turenhout Leo GM van Rossum Frank A Oort Robert JF Laheij Anne F van Rijn Jochim S Terhaar sive Droste Paul Fockens René WM van der Hulst Anneke A Bouman Jan BMJ Jansen Gerrit A Meijer Evelien Dekker Chris JJ Mulder | 2012 | World Journal of Gastroenterology2012，18，38： | 0 |
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