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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | International table of glycemic index and glycemic load values: 2002 显示文摘 | Kate F P Susanna H A Janette C B M | 2002 | American Journal of Clinical Nutrition2002，76，： | 1 |
| 3 | Concentration and distribution of sialic acid in human milk and infant formulas 显示文摘 | BING W JANETTE B M PATRICIA M V | 2001 | Am J Clin Nutrition2001，74，4： | 1 |
| 4 | Concentration anddistribution of sialic acid in human milk and infant formulas 显示文摘 | Wang B Janette B Patricia M | 2001 | The American Journal of Clinical Nutrition2001，74，： | 1 |
| 5 | Monitoring of malting process by characterization of glycation of barley protein Z 显示文摘 | Janette B Inga PP Marketa L | 2010 | Eur Food Res Technol2010，230，： | 1 |
| 6 | Amylopectin Starch Promotes the Development of Insulin Resistant in Rats显示文摘 | Suzzanne E B Janette C B M Gareth S D | 2006 | The Journal of Nutrition2006，125，3： | 1 |
| 7 | Evaluation of twenty rapid antigen tests for the detection of human influenza A H5N1, H3N2, H1N1, and B Viruses 显示文摘 | Janette T Kenneth M Julian D Chris B | 2009 | J Medical Virology2009，81，19： | 1 |
| 8 | The relation ship of cumulative and proximal adversity to onset of sub stance dependence symptoms in two American Indian corn munities显示文摘 | Nancy RW Janette B Christina MM et af | 2007 | Drug and Alcohol Dependence2007，91，： | 1 |
| 9 | Concentration and Distribution of Sialic Acid in Human Milk and Infant Formulas 显示文摘 | WANG B JANETTE B M PATRICIA M | 2001 | American J Clin Nutrition2001，74，4： | 1 |
| 10 | TAG, You' re it ! Chlamydomonas as a reference organism for understanding algal triacylglycerol accumulation显示文摘 | SABEEHA S MERCHANT JANETTE KROPAT LIU B | 2012 | Curt Opin Biotech2012，23，3： | 1 |
| 11 | Concentration and distribution of sialic acid in human milk and infant formulas 显示文摘 | Bing W Janette B M Patricia M V | 2001 | Am J Clin Nutrition2001，74，4： | 1 |
| 12 | Prevalence of common psychiatric disorders among American Indian adolescent detainees显示文摘 | Wilson DC Janette B Douglas KN | 1998 | J Am Acad Child Adolesc Psychiatry1998，37，8： | 1 |
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