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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | International table of glycemic index and glycemic load values:2002显示文摘 | Susanna HA Janette C | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 3 | International table of glycemic index and glycemic load values: 2002 显示文摘 | Kaye FP Susanna HA Janette C | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 4 | International table of glycemic index and glycemic load values: 2002 显示文摘 | Kate F P Susanna H A Janette C B M | 2002 | American Journal of Clinical Nutrition2002，76，： | 1 |
| 5 | Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicu- lar development, serum testosterone levels and physi- cal activity in pubertal bulls 显示文摘 | JANETT F GERIG T TSCHUOR A C | 2012 | Theriogenology2012，78，1： | 1 |
| 6 | Importance of glycemic index in diabetes显示文摘 | MILLER JANETTE C | 1994 | Am J Clin Nutr1994，59，3： | 1 |
| 7 | The tomato rhizosphere, an environment rich in nitrogen-fixing Burkholderia species with capabilities of interest for agriculture and bioremediation显示文摘 | Jesus C M Janette O L Paulina E S | 2007 | Applied and Envi- ronmental Microbiology2007，73，： | 1 |
| 8 | Low magnitude mechanical loading is osteogenic in children with disabling conditions 显示文摘 | Kate W Chrissie A Janette C | 2004 | Journal of Bone and Mineral Research2004，19，3： | 1 |
| 9 | Importance of glycemic index in diabetes 显示文摘 | Janette C | 1994 | AmericanJournal of Clinical Nutrition1994，59，3： | 1 |
| 10 | International Table of Glycemic Index and Glycemic Load Values: 2002 显示文摘 | Kaye FP Susanna HA Janette C | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 11 | International table of glycemicindex and glycemic load values显示文摘 | Kay FP Susanna HA Janette C | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 12 | Regulation of periplasmic carbonic anhydrase expression in Chlamydomonas reinhardtii by acetate and pH显示文摘 | Janette P F John R C | 1994 | Plant Physiology1994，106，： | 1 |
| 13 | Low magnitude mechanical loading is osteogenic in children with disabling conditions 显示文摘 | Kate W Chrissie A Janette C | 2004 | Journal of Bone and Mineral Research2004，19，3： | 1 |
| 14 | Amylopectin Starch Promotes the Development of Insulin Resistant in Rats显示文摘 | Suzzanne E B Janette C B M Gareth S D | 2006 | The Journal of Nutrition2006，125，3： | 1 |
| 15 | Vaccination against gonadotropin- releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls 显示文摘 | Janett F Gerig T Tschuor A C Amatayakul-Chantler S Walker J Howard R Bollwein H Thun R | 2012 | Theriogenology2012，78，1： | 1 |
| 16 | Regulation of periplasmic carbonic anhydrase expression in Chlamydomonas reinhardtii by acetate and pH显示文摘 | Janette P E John R C | 1994 | Plant Physiology1994，106，： | 1 |
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