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| 1 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 2 | Cell adhesion molecules in coronary artery disease 显示文摘 | Jang Y Lincoff AM Plow EF | 1994 | J Am Coll Cardiol1994，24，： | 1 |
| 3 | Signaling from cytokinereceptors that affect Th1 responses显示文摘 | HANLON AM JANG S SALGAME P | 2002 | Front Biosci2002，7，： | 1 |
| 4 | Influence of local delivery of the protein kinase receptor inhibitor tyrphostin-47 on smooth muscle cell proliferation in a rat carotid balloon-injury model显示文摘 | Gottsauner WM Jang Y Lincoff AM | 1997 | Am Heart J1997，133，3： | 1 |
| 5 | The effects of di- gestion temperature and temperature shock on the biogas yields from the mesophilic anaerobic digestion of swine manure 显示文摘 | Chae K J Jang Am Yim S K | 2008 | Bioresouree Technology2008，99，： | 1 |
| 6 | Characterization of Aerobic Granules by Microbial Density at Different COD Loading Rates 显示文摘 | In SKim Sung - Min Kim Am Jang | 2008 | Bioresource Technology2008，，99： | 1 |
| 7 | Characterization of aerobic granules by microbial density at different COD loading rates 显示文摘 | Kim In S Kim Sung-Min Jang Am | 2008 | Bioresour Technol2008，99，1： | 1 |
| 8 | Cell adhesion molecules in coronary artery disease显示文摘 | Jang Y Lincoff AM Plow EF Topol EJ | | 0，，： | 1 |
| 9 | The effects of digestion temperature and temperature shock on the biogas yields from the mesophilic anaerobic digestion of swine manure 显示文摘 | K J Chae Am Jang S K Yim | 2008 | Bioresource Technology2008，，： | 1 |
| 10 | The effects of digestion temperature and temperature shock on the biogas yields from the mesophilie anaerobic digestion of swine manure显示文摘 | Chae K J Jang Am Yim S K | 2008 | Bioresource Technology2008，99，： | 1 |
| 11 | Cell adhesion mole-cules in coronary artery disease显示文摘 | Jang Y Lincoff AM Plow EF | 1994 | J Am Coll Cardiol1994，24，： | 1 |
| 12 | Cell adhesion mole- cules in coronary artery disease 显示文摘 | Jang Y Lincoff AM Plow EF | 1994 | J Am Coil Cardiol1994，24，7： | 1 |
| 13 | Characterization and evaluation of aerobic granules in sequencing batch reactor显示文摘 | Am Jang Young-Han Yoon In SKim et ol | 2003 | Biotechnology2003，105，12： | 1 |
| 14 | Cell adhesion molecules in coronary artery disease显示文摘 | Jang Y Lincoff AM Plow EF | | 0，，06： | 1 |
| 15 | Characterization and evaluation of aerobic granules in SBR显示文摘 | Jang Am Yoon Young hua Kim InS | 2003 | J Biotech2003，105，： | 1 |
| 16 | Bioleaching of heavy metals from dewatered sludge by Acidithiobacillus ferroox-idans 显示文摘 | In S Kim Jong-Un Lee Am Jang | 2005 | Journal of Chemical Technology and Biotech- nology2005，80，： | 1 |
| 17 | Bioleaching of heavy metals from dewatered sludge by Acidithiobacillus ferrooxidans 显示文摘 | In SKim Jong-Un Lee Am Jang | 2005 | J of Chemi Tech and Biotech2005，80，： | 1 |
| 18 | The effects of digestion temperature and temperature shock on the biogas yield from the mesophilic anaerobic digestion of swine manure显示文摘 | K J Chae Am Jang S K Yim | 2008 | Bioresource Technology2008，，99： | 1 |
| 19 | Characterization and evaluation of aerobic granules in SBR 显示文摘 | Am Jang Young-hua Yoon In S Kim | 2003 | J Biotech2003，105，12： | 1 |
| 20 | Bioleaching of heavy metals from dewatered sludge by Acidithiobacillus ferroox- idans显示文摘 | In SKim Jong-Un Lee Am Jang | 2005 | Journal of Chemical Technology and Bioteeh- nology2005，80，： | 1 |
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