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| 1 | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. | Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 3 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 4 | Cancer chemopreventive activity of resveratrol,a natural product derived from grapes显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，： | 2 |
| 5 | Modeling and High -precision Control of a Ball-screw-drive Stage 显示文摘 | Chen C L Jang M J Lin K C | 2004 | Precision Engineering2004，28，： | 1 |
| 6 | Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant 显示文摘 | ZHOU L JANG J C JONES T L | 1998 | PNAS1998，95，10： | 1 |
| 7 | The role of cytokines in prostatitis 显示文摘 | Jang T L Schaeffer A J | 2003 | World J Uroi2003，21，2： | 1 |
| 8 | Cancer chemopreventive ac- tivity of resveratrol, a natural product derived from grapes 显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，5297： | 1 |
| 9 | Influence of Pb segregation on the deformation of nanocrystalline Al:Insights from molecular simulations显示文摘 | Jang S Urohit Y Irving D L | 2008 | Acta Mater2008，56，： | 1 |
| 10 | Lift enhancement of an airfoil using a gurney flap and vortex generators 显示文摘 | Storms B L Jang C S | 1994 | Journal of Air- craft1994，31，3： | 1 |
| 11 | Cancer chemopreventive activity of resveratrol, a natural product derived from grapes显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，5297： | 1 |
| 12 | Strapdown INS error model for muhiposition alignment 显示文摘 | DOHYOUNG C JANG G L CHAN G P | 1996 | IEEE Transactions on Aerospace and Electronic Systems1996，32，4： | 1 |
| 13 | 显示文摘 | Jang S J Cross L E Wuttig M | 1990 | J Appl Phys1990，68，6： | 1 |
| 14 | Cancer chemopreventive activity of resveratrol,anatural product derived from grapes显示文摘 | Jang M Cai L Udeani G O | 1997 | Science1997，275，10： | 1 |
| 15 | Electroantennogram responses of the oriental fruit fly, Dacus dorsalis, to a spectrum of alcohol and aldehyde plant volatiles显示文摘 | DOUGLAS M L JANG E B | 1987 | Entomologia Experimentalis et Applicata1987，45，： | 1 |
| 16 | Engaging students in learning activities:it is not autonomy support or structure but autonomy support and structure显示文摘 | JANG H REEVE J DECI E L | | 0，，03： | 1 |
| 17 | Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis 显示文摘 | Jang S J Sofia JC Wang L | 2001 | Cancer Res2001，61，21： | 1 |
| 18 | High frequency of two mutations in codon 778 in exon 8 of the ATPTB gene in Taiwanese families with Wilson disease 显示文摘 | Chuang L M Wu H P Jang M H Wang T R Sue W C Lin B J | 1996 | J Med Genet1996，33，： | 1 |
| 19 | Regeneration patterns and tree species coexistence in old growth Abies Picea forests in southwestern China显示文摘 | Taylor A H Jang S W Zhao L J | 2006 | Forest Ecology and Management2006，223，： | 1 |
| 20 | Blind channel estimation in MIMO-OFDM syetems显示文摘 | BAI W CHEN H E JANG L | 2002 | IEICE Trans Comrnun2002，85，9： | 1 |
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