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| 1 | Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder显示文摘AIM:To investigate the preoperative factors that can predict neoplastic polypoid lesions of the gallbladder(PLGs) as well as malignant PLGs.METHODS:A retrospective analysis was conducted on the 210 consecutively enrolled patients who underwent cholecystectomy due to a PLG larger than 10 mm,as was determined by preoperative trans-abdominal ultrasonography or endoscopic ultrasonography.We ana-lyzed the medical,laboratory,radiologic data and the pathologic results.RESULTS:In 210 cases,146 had non-neoplastic polyps(69.5%) and 64 cases were neoplastic polyps(30.5%).An older age(≥ 65 years),the presence of diabetes mellitus(DM) and the size of polyp(≥ 15 mm) were revealed to be independent predictive variables for neoplastic polyps with odd ratios(OR) of 2.27(P = 0.044),2.64(P = 0.021) and 4.94(P < 0.01),respectively.Among the neoplastic PLGs,an older age(≥ 65 years),the presence of DM and polyp size(≥ 15 mm) were associated with malignancy with ORs of 4.97(P = 0.005),6.13(P = 0.001) and 20.55(P < 0.001),respectively.CONCLUSION:Among patients with PLGs larger than 10 mm in size,higher risk groups such as elderly patients more than 65 years old,those with DM or a large polyp size(≥ 15 mm) should be managed by cholecystectomy. | Byung Hyo Cha Jin-Hyeok Hwang Sang Hyub Lee Jang Eon Kim Jai Young Cho Haeryoung Kim So Yeon Kim | 2011 | World Journal of Gastroenterology2011，17，17： | 27 |
| 2 | Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan显示文摘AIM: To evaluated the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan in diagnosis of hepatocellular carcinoma (HCC) and extrahepatic metastases. METHODS: A total of 138 patients with HCC who had both conventional imaging modalities and 18F-FDG PET/CT scan done between November 2006 and March 2011 were enrolled. Diagnostic value of each imaging modality for detection of extrahepatic metastases was evaluated. Clinical factors and tumor characteristics including PET imaging were analyzed as indicative factors for metastases by univariate and multivariate methods. RESULTS: The accuracy of chest CT was significantly superior compared with the accuracy of PET imaging for detecting lung metastases. The detection rate of metastatic pulmonary nodule ≥ 1 cm was 12/13 (92.3%), when < 1 cm was 2/10 (20%) in PET imaging. The accuracy of PET imaging was significantly superior compared with the accuracy of bone scan for detecting bone metastases. In multivariate analy- sis, increased tumor size (≥ 5 cm) (P = 0.042) and increased average standardized uptake value (SUV) uptake (P = 0.028) were predictive factors for extrahepatic metastases. Isometabolic HCC in PET imaging was inversely correlated in multivariate analysis (P = 0.035). According to the receiver operating characteristic curve, the optimal cutoff of average SUV to predict extrahepatic metastases was 3.4. CONCLUSION: 18F-FDG PET/CT scan is invaluable for detection of lung metastases larger than 1 cm and bone metastases. Primary HCC having larger than 5 cm and increased average SUV uptake more than 3.4 should be considered for extrahepatic metastases. | Ji Eun Lee Jae Young Jang Soung Won Jeong Sae Hwan Lee Sang Gyune Kim Sang-Woo Cha Young Seok Kim Young Deok Cho Hong Soo Kim Boo Sung Kim So Young Jin Deuk Lin Choi | 2012 | World Journal of Gastroenterology2012，18，23： | 10 |
| 3 | Anti-Proliferative Effects of Ginsenosides Extracted from Mountain Ginseng on Lung Cancer显示文摘Objective:To investigate the effect of three major ginsenosides from mountain ginseng as anticancer substance and explore the underlying mechanism involved in lung cancer.Methods:The inhibitory proliferation of lung cancer by major five ginsenosides(Rb1,Rb2,Rg1,Re,and Re) was examined using3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.Calculated 50%inhibition(IC_(50)) values of five ginsenosides were determined and compared each other.Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy.The alterations of apoptosis-related proteins were evaluated by Western blot analysis.Results:The abundance of ginsenosides in butanol extract of mountain ginseng(BX-MG) was revealed in the order of Rb1,Rg1,Re,Re and Rb2.Among them,Rb1 was the most effective to lung cancer cell,followed by Rb2 and Rg1 on the basis of relative IC_(50) values of IMR90 versus A549 cell.The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rb1,Rb2 and Rg1.The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides,however,the levels of caspase-9 and anti-apoptotic protein Bax were not changed.Conclusion:Major ginsenosides such as Rb1,Rb2 and Rg1 comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway. | Dong Gyu Lee Sung-ll Jang Young-Rang Kim Kyeong Eun Yang So Jung Yoon Zee-Won Lee Hyun Joo An Ik-Soon Jang Jong-Soon Choi Hwa-Seung Yoo | 2016 | Chinese Journal of Integrative Medicine2016，22，5： | 9 |
| 4 | Molecular Features of Colorectal Hyperplastic Polyps and Sessile Serrated Adenoma/Polyps From Korea显示文摘 | Kyoung-Mee Kim Eui Jin Lee Sangyun Ha So Young Kang Kee-Taek Jang Cheol Keun Park Jin Yong Kim Young Ho Kim Dong Kyung Chang Robert Daniel Odze | 2011 | The American Journal of Surgical Pathology2011，，： | 2 |
| 5 | Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration显示文摘Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical practices.In recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this limitation.Herein,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation method.It was observed that the GBR membrane allows continuous release of pDNA for more than20 weeks.The pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of BMP-2.From in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration. | Se Heang Oh June-Ho Byun So Young Chun Young-Joo Jang Jin Ho Lee | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 6 | Calcium-dependent proteasome activation is required for axonal neurofilament degradation显示文摘Even though many studies have identified roles of proteasomes in axonal degeneration,the molecular mechanisms by which axonal injury regulates proteasome activity are still unclear.In the present study,we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves.In degenerating axons,the increase in proteasome activity and the degradation of ubiquitinated proteins were significantly suppressed by extracellular calcium chelation.In addition,electron microscopic findings revealed selective inhibition of neurofilament degradation,but not microtubule depolymerization or mitochondrial swelling,by the inhibition of calpain and proteasomes.Taken together,our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration. | Joo Youn Park So Young Jang Yoon Kyung Shin Duk Joon Suh Hwan Tae Park | 2013 | Neural Regeneration Research2013，8，36： | 2 |
| 7 | Histological improvement following administration of autologous bone marrow‐derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study显示文摘 | Yoon Ok Jang Young Ju Kim Soon Koo Baik Moon Young Kim Young Woo Eom Mee Yon Cho Hong Jun Park So Yeon Park Bo Ra Kim Jae Woo Kim Hyun Soo Kim Sang Ok Kwon Eun Hee Choi Yong Man Kim | 2014 | Liver Int2014，，1： | 2 |
| 8 | Zn-doped nickel iron(oxy)hydroxide nanocubes passivated by polyanions with high catalytic activity and corrosion resistance for seawater oxidation显示文摘Electrochemical water splitting to produce hydrogen fuel is a promising renewable energy-conversion technique.Large-scale electrolysis of freshwater may deplete water resources and cause water scarcity worldwide.Thus,seawater electrolysis is a potential solution to the future energy and water crisis.In seawater electrolysis,it is critical to develop cost-effective electrocatalysts to split seawater without chloride corrosion.Herein,we present zinc-doped nickel iron(oxy)hydroxide nanocubes passivated by negatively charged polyanions(NFZ-PBA-S)that exhibits outstanding catalytic activity,stability,and selectivity for seawater oxidation.Zn dopants and polyanion-rich passivated surface layers in NFZ-PBA-S could effectively repel chlorine ions and enhance corrosion resistance,enabling its excellent catalytic activity and stability for seawater oxidation. | So Jung Kim Heechae Choi Jeong Ho Ryu Kang Min Kim Sungwook Mhin Arpan Kumar Nayak Junghwan Bang Minyeong Je Ghulam Ali Kyung Yoon Chung Kyeong-Han Na Won-Youl Choi Sunghwan Yeo Jin Uk Jang HyukSu Han | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 9 | Asthma prevention by Lactoba- ciUus rhamnosus in a mouse modal is associated with CD4( + )CD25 ( + )Foxp3( + ) T cells显示文摘 | Jang SO Kim H J Kim YJ | 2012 | Allergy Asthma Immunol Res2012，4，3： | 1 |
| 10 | Formation of intracardiac thrombus during cardiopulmonary bypass despite full heparinization and adequate activated clotting time -A case report 显示文摘 | So YK Song JW Jang YS | 2012 | Korean J Anesthesiol2012，62，6： | 1 |
| 11 | Preparation of nanosized crystalline CdS particles by the hydrothermal treatment显示文摘 | So W Jang J Rhee Y | 2001 | J Colloid Interface Sci2001，237，： | 1 |
| 12 | Preparation of nanosized crystalline CdS particles by the hydrothermal treatment 显示文摘 | So W W Jang J S Rhee Y W | 2001 | Journal of Colloid and Interface Science2001，237，： | 1 |
| 13 | Evaluation of changes induced by temperature, contact time, and surface in the efficacies of disin- fectants against avian influenza virus 显示文摘 | Jang Y Lee J So B | 2014 | Poult Sei2014，93，1： | 1 |
| 14 | CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma显示文摘 | Baek-hui Kim Nam-Yun Cho So Hyun Shin Hyeong-Ju Kwon Ja June Jang Gyeong Hoon Kang | 2009 | Virchows Archiv2009，，4： | 1 |
| 15 | Application of alvarado score in patients with suspected appendicitis显示文摘 | Jang SO Kim BS Moon DJ | 2008 | Korean J Gastroenterol2008，52，1： | 1 |
| 16 | Caudal-related homeodomain proteins CDX1/2 bind to DNA replication-related element binding factor显示文摘 | So Young Park Mi Suk Jeong Mi-Ae Yoo Se Bok Jang | 2011 | BBA - Proteins and Proteomics2011，，12： | 1 |
| 17 | Adenosine reduces GABAergic IPSC frequency via presynaptic A 1 receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla显示文摘 | Tae Hee Han Soo Hwa Jang So Yeong Lee Pan Dong Ryu | 2010 | Neuroscience Letters2010，，1： | 1 |
| 18 | Preparation of nanosized crystalline CdS particles by the hydrothermal treatment显示文摘 | SO W JANG J RHEE Y | 2001 | Journal of Colloid and Interface Science2001，237，1： | 1 |
| 19 | Asthma prevention by Lactobacillus Rhamnosus in a mouse model is associated with CD4(+)CD25(+)Foxp3(+) T cells显示文摘 | Jang SO Kim HJ Kim YJ | 2012 | Allergy Asthma Immunology Research2012，4，3： | 1 |
| 20 | Dogs cloned from fetal fibroblasts by nuclear transfer显示文摘 | So Gun Hong Goo Jang Min Kyu Kim Hyun Ju Oh Jung Eun Park Jung Taek Kang Ok Jae Koo Dae Yong Kim Byeong Chun Lee | 2008 | Animal Reproduction Science2008，，1： | 1 |
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