|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome显示文摘AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition. | Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright | 2010 | World Journal of Gastroenterology2010，16，36： | 13 |
| 2 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 3 | Transgenic bioreactors显示文摘 | Janne J Alhonen L Hyttinen J M | 1998 | Biotecbnol Annu Rev1998，56，4： | 1 |
| 4 | Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective 显示文摘 | Desai HD Seabolt J Jann MW | 2001 | CNS Drugs2001，15，6： | 1 |
| 5 | EGFR mutations in lung cancercorrelation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 6 | Self-reported empathic a- bilities in schizophrenia: A longitudinal perspective 显示文摘 | Haker H Schimansky J Jann S | 2012 | Psychia- try Res2012，200，23： | 1 |
| 7 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | | 0，，5676： | 1 |
| 8 | Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke显示文摘 | Jannes J Hamilton-Bruce MA Pilotto L | 2004 | Stroke2004，35，： | 1 |
| 9 | Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman J A Janne P A | | 0，，10： | 1 |
| 10 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 11 | Prognostic rele- vance of a novel TNM classification system for upper gastroentero- pancreatic neuroendocrine tumors 显示文摘 | Pape UF Jann H Muller-Nordhorn J | 2008 | Cancer2008，113，2： | 1 |
| 12 | Resetting semiactives tiffness damper for seismic response control 显示文摘 | Jann N Y Kim J H Anil K A | 2000 | ASCE Journal of Structural Engineering2000，126，14： | 1 |
| 13 | Transgenic animals as bio- producers of therapeutic proteins 显示文摘 | Janne J Hyttinen J M Peura T | 1992 | Annals of Internal Medicine1992，24，： | 1 |
| 14 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，5676： | 1 |
| 15 | Chemo-radiotherapy and gefinitib in stage Ⅲ Non-small Cell Lung Cancer:a CALGB stratified phase Ⅱ trial显示文摘 | Ready N Janne P Herndon J | 2006 | J Clin Oncol2006，24，： | 1 |
| 16 | Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke显示文摘 | Jannes J Hamilton-Bruce MA Pilotto L | | 0，，： | 1 |
| 17 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，204，5676： | 1 |
| 18 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib ther apy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，： | 1 |
| 19 | Tissue plasm inogen activator-7351C/T enhancer polymorphism is a risk factor for lacunar stroke显示文摘 | Jannes J Hamilton-Bruce MA Pilotto L | 2004 | Stroke2004，35，5： | 1 |
| 20 | Stabilization of mercury containing sludge by a combined process of 2-stage pretreatment and solidification 显示文摘 | Chang C Y Hsu C P Jann J S | 1993 | Journal of Hazardous Material1993，35，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员