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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen J O Thomas R Loudon M A | 2009 | BMJ2009，338，： | 1 |
| 3 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen JO Thomas R Loudon MA | 2009 | BMJ2009，338，： | 1 |
| 4 | Diffuse Scattering From Rough Surfaces in THz Communication Channels显示文摘 | Christian Jansen Sebastian Priebe Thomas K ü rner | | 0，，2： | 1 |
| 5 | Detection of antibiotic-resistant bacteria and their resistance genes in wastewater,surface water,and drinking water biofilms显示文摘 | Thomas Schwartz Wolfgang Kohnen Bernd Jansen | 2003 | FEMS Microbiology Ecology2003，43，3： | 1 |
| 6 | The cooperative coevolutionary ( 1 + 1) EA显示文摘 | Thomas Jansen Paul Wiegand R | 2004 | Evolutionary Computation2004，12，4： | 1 |
| 7 | Handover parameter optimization in LTE self-organizing network显示文摘 | Thomas Jansen | 2010 | IEEE Communication Letters2010，，6： | 1 |
| 8 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen JO Thomas R Loudon MA | 2009 | BMJ2009，338，： | 1 |
| 9 | JULIUS-an extendableap plication framework for medical visualization and surgical planning显示文摘 | Bartosz von Rymon-Lipinski Thomas Jansen Zdzislaw Krol | 2001 | International Congress Series2001，12，3： | 1 |
| 10 | Handover parameter optimization in LTE self-organizing network显示文摘 | Thomas Jansen | 2010 | IEEE Communication Letters2010，，6： | 1 |
| 11 | Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells显示文摘 | Tobias Busch Milena Armacki Tim Eiseler Golsa Joodi Claudia Temme Julia Jansen G?tz von Wichert M. Bishr Omary Joachim Spatz Thomas Seufferlein | 2012 | Journal of Cell Science2012，，9： | 1 |
| 12 | Mitochondrial DNA and the origins of the domestic horse显示文摘 | Jansen Thomas Forster Peter Levine Marsha A | 2002 | PNAS2002，99，10： | 1 |
| 13 | Synthesis and characteriza- tion of new amorphous Si/B/N/C ceramics with increased carbon content through single-source precursors显示文摘 | Thomas Jaschke Martin Jansen | 2004 | C R Chimie2004，7，： | 1 |
| 14 | A new borazine-type single source precursor for Si/B/N/C ceramics 显示文摘 | Thomas Jaschke Martin Jansen | 2006 | J Mater Chem2006，16，： | 1 |
| 15 | Real royal road functions—where crossover provably is essential显示文摘 | Thomas Jansen Ingo Wegener | 2005 | Discrete Applied Mathematics2005，，1： | 1 |
| 16 | Chicken NK cell receptors显示文摘 | Christian Straub Marie-Luise Neulen Beatrice Sperling Katharina Windau Maria Zechmann Christine A. Jansen Birgit C. Viertlboeck Thomas W. G?bel | 2013 | Developmental and Comparative Immunology2013，，： | 1 |
| 17 | Damage control resus- citation for patients with major trauma 显示文摘 | Jansen JO Thomas R Loudon MA | 2009 | BMJ2009，338，： | 1 |
| 18 | Detection of antibiotic- resistant bacteria and their resistance genes in waste water, surface water, and drinking water biofilms 显示文摘 | Kohnen Wolfgang Jansen Bernd | 2003 | FEMS Microbiology Ecology2003，43，3： | 1 |
| 19 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen JO Thomas R Loudon MA | | 0，，： | 1 |
| 20 | Handover parameter optimization in LTE self-organizing network显示文摘 | Thomas Jansen | 2010 | IEEE Communication Letters2010，，6： | 1 |
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