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| 1 | Frontiers in antibiotic alternatives for Clostridioides difficile infection显示文摘Clostridioides difficile(C.difficile)is a gram-positive,anaerobic spore-forming bacterium and a major cause of antibiotic-associated diarrhea.Humans are naturally resistant to C.difficile infection(CDI)owing to the protection provided by healthy gut microbiota.When the gut microbiota is disturbed,C.difficile can colonize,produce toxins,and manifest clinical symptoms,ranging from asymptomatic diarrhea and colitis to death.Despite the steady-if not risingprevalence of CDI,it will certainly become more problematic in a world of antibiotic overuse and the post-antibiotic era.C.difficile is naturally resistant to most of the currently used antibiotics as it uses multiple resistance mechanisms.Therefore,current CDI treatment regimens are extremely limited to only a few antibiotics,which include vancomycin,fidaxomicin,and metronidazole.Therefore,one of the main challenges experienced by the scientific community is the development of alternative approaches to control and treat CDI.In this Frontier article,we collectively summarize recent advances in alternative treatment approaches for CDI.Over the past few years,several studies have reported on natural product-derived compounds,drug repurposing,highthroughput library screening,phage therapy,and fecal microbiota transplantation.We also include an update on vaccine development,pre-and probiotics for CDI,and toxin antidote approaches.These measures tackle CDI at every stage of disease pathology via multiple mechanisms.We also discuss the gaps and concerns in these developments.The next epidemic of CDI is not a matter of if but a matter of when.Therefore,being well-equipped with a collection of alternative therapeutics is necessary and should be prioritized. | Matthew Phanchana Phurt Harnvoravongchai Supapit Wongkuna Tanaporn Phetruen Wichuda Phothichaisri Supakan Panturat Methinee Pipatthana Sitthivut Charoensutthivarakul Surang Chankhamhaengdecha Tavan Janvilisri | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | Charge modifica- tion at conserved positively charged residues of fatty acid binding protein (FABP) from the giant liver fluke Fasciola gigantica: its effect on olignmerization and binding properties 显示文摘 | Janvilisri T Likitponrak W Chunehob S | 2007 | Mol Cell Bio- cbem2007，305，12： | 1 |
| 3 | Nasopharyngeal carcinoma signaling pathway:an update on molecular biomarkers 显示文摘 | Tulalamba W Janvilisri T | 2012 | Int J Cell Biol2012，，2012： | 1 |
| 4 | ABCG transporters: structure, substrate specificities and physiological roles: a grief overview 显示文摘 | Velamakanni S Wei SL Janvilisri T | 2007 | J Bioenerg Biomembr2007，39，56： | 1 |
| 5 | Association between multidrug resistance–associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy显示文摘 | Noppadol Larbcharoensub Juvady Leopairat Ekaphop Sirachainan Ladawan Narkwong Thongchai Bhongmakapat Kawin Rasmeepaisarn Tavan Janvilisri | 2008 | Human Pathology2008，，6： | 1 |
| 6 | Novel serum biomarkers to differentiate cholangioearcinoma from benign biliary tract diseases using a proteomia approach 显示文摘 | JANVILISRI T LEELAWAT K ROYTRAKUL S et o2 | 2015 | Disease Markers2015，2015，10： | 1 |
| 7 | Interaction of the breast cancer resistance protein with plant polyphenols显示文摘 | Cooray HC Janvilisri T van Veen HW | 2004 | Biochem Biophys Res Commun2004，317，1： | 1 |
| 8 | Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein ( ABCG2 ) 显示文摘 | Janvilisri T Shahi S Venter H | 2005 | Biochem J2005，385，2： | 1 |
| 9 | Nasopharyngeal carcinoma signaling pathway:an update on molecular biomarkers显示文摘 | Tulalamba W Janvilisri T | 2012 | Int J Cell Biol2012，2012，59： | 1 |
| 10 | Omics - based identification of biomarkers for nasopha- ryngeal carcinoma 显示文摘 | Janvilisri T | 2015 | Dis Markers2015，2015，76： | 1 |
| 11 | Nasopharyngeal carcinoma sig- naling pathway : an update on molecular biomarkers 显示文摘 | Tulalamba W Janvilisri T | 2012 | Int J Cell Biol2012，2012，59： | 1 |
| 12 | Interaction of the breast cancer resistance protein with plant polyphenols 显示文摘 | Cooray HC Janvilisri T van Veen HW | 2004 | Biochem Biophys Res Commun2004，317，1： | 1 |
| 13 | Dysregulation of microRNA in cholangiocarcinoma identified through a meta-analysis of microRNA profiling显示文摘BACKGROUND In the past decades,the potential of microRNA(miRNA)in cancer diagnostics and prognostics has gained a lot of interests.In this study,a meta-analysis was conducted upon the pooled miRNA microarray data of cholangiocarcinoma(CCA).AIM To identify differentially expressed(DE)miRNAs and perform functional analyses in order to gain insights to understanding miRNA-target interactions involved in tumorigenesis pathways of CCA.METHODS Raw data from 8 CCA miRNA microarray datasets,consisting of 443 samples in total,were integrated and statistically analyzed to identify DE miRNAs via comparison of levels of miRNA expression between CCA and normal bile duct samples using t-tests(P<0.001).The 10-fold cross validation was performed in order to increase the robustness of the t-test results.Our data showed 70 up-regulated and 48 down-regulated miRNAs in CCA. GeneOntology and pathway enrichment analyses revealed that mRNA targets of DEmiRNAs were significantly involved in several biological processes. The mostprominent dysregulated pathways included phosphatidylinositol-3 kinases/Akt,mitogen-activated protein kinase and Ras signaling pathways.CONCLUSIONDE miRNAs found in our meta-analysis revealed dysregulation in major cancerpathways involved in the development of CCA. These results indicated thenecessity of understanding the miRNA-target interactions and the significance ofdysregulated miRNAs in terms of diagnostics and prognostics of cancers. | Somsak Likhitrattanapisal Supeecha Kumkate Pravech Ajawatanawong Kanokpan Wongprasert Rutaiwan Tohtong Tavan Janvilisri | 2020 | World Journal of Gastroenterology2020，26，29： | 0 |
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