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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens显示文摘 | Krzych U Lyon JA Jareed T | 1995 | J Immunol1995，155，8： | 1 |
| 4 | Off - pump versus on - pump coronary artery surgery显示文摘 | JARES M VANEK T BEDNAR F | 2007 | Int Heart J2007，48，1： | 1 |
| 5 | Photosensi- tive Pt (IV) - azide prodrug - loaded nanopartieles exhibit con- trolled drug release and enhanced efficacy in vivo显示文摘 | Haihua Xiao Gavin T Noble Jared F Stefanick | 2014 | J Controlled Release2014，173，： | 1 |
| 6 | Resistance studies with daptomycin显示文摘 | Jared A Oliver N Andrew T | 2001 | Antimicrob Agents Chemother2001，45，6： | 1 |
| 7 | Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting显示文摘 | Jares M Vanek T Straka Z | 2003 | J Cardiovasc Surg (Torino)2003，44，2： | 1 |
| 8 | Fibrinolytic inhibitors in off pump coronary surgery: a prospective, randomized double blind TAP study (tranexamic acid, aprotinin, pla cebo) 显示文摘 | Vanek T jares M Fajt R | 2005 | Eur J Cardio-Thoracic Sur2005，28，4： | 1 |
| 9 | Laurencin Mater Lett显示文摘 | Justin Lee Brown Lakshmi S Nair Jared Bender Harry R Allcock Cato T | 2007 | 61 : 3 6922007，61，： | 1 |
| 10 | Tranexamic acid re- duces bleeding after off-pump coronary artery bypass grafting显示文摘 | Jares M Vanek T Straka Z | 2003 | J Cardiovasc Sur2003，44，2： | 1 |
| 11 | A molecular phylogenetic analysis of strombid gastropod morphological diversity 显示文摘 | JARED M L MICHAEL S T KAUSTUV R | 2006 | Molecular Phylogenetics and Evolution2006，41，： | 1 |
| 12 | Excimer laserprocessed donor corneal lenticules for lamellar keratoplasty显示文摘 | Gabay S Slomovic A Jares T | 1989 | Am J Ophthalmol1989，107，： | 1 |
| 13 | Tranexamic acid reduces bleeding after off-pump coronary arterybypass gratting显示文摘 | Jares M Vanek T Straka Z | 2003 | J Card- iovasc Surg (Torino)2003，44，2： | 1 |
| 14 | Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant显示文摘 | CARBALLA M OM1L F LEMA J LIOMPART M GARCIA - JARES C RODRIGUEZ I GOMEZ M TERNES T | 2004 | Water Res2004，38，12： | 1 |
| 15 | Fibrinolytic inhibitors in off - pump coronary surgery : a prospective, randomized, double -blind TAP study (tranexamic acid, aprotinin, placebo )显示文摘 | Vanek T Jares M Vajt R | 2005 | EurJ Cardiothorac Surg2005，28，4： | 1 |
| 16 | Ranolazine reduces ventrie- ular tachycardia burden and ICD shocks in patients with drug- refractory ICD shocks显示文摘 | Jared T Srijoy M David M | 2011 | PACE2011，34，12： | 1 |
| 17 | FRET imaging显示文摘 | JARES -ERIJMAN E A JOVIN T M | 2003 | Nat Biotechnol2003，21，： | 1 |
| 18 | FRET imaging显示文摘 | JARES E E A JOVIN T M | 2003 | Nature Bioteehnology2003，，： | 1 |
| 19 | Fret Imaging 显示文摘 | JARES E E A JOVIN T M | 2003 | Nat Biotechnol2003，21，11： | 1 |
| 20 | Developmental expres- sion of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (Danio rerio) 显示文摘 | John M T Sonja G Jared A | 2001 | Journal of Ex- perimental Zoology2001，290，5： | 1 |
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