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| 1 | Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation显示文摘BackgroundMedication 坚持是有收到口头的 anticoagulations (OAC ) 的 atrial 纤维性颤动(AF ) 的病人的全面照顾的不可分的部分治疗。有 AF 的许多病人是老的并且可以受不了认知缺陷的某形式。这研究被进行调查认知缺陷是否在包含的 AF patients.MethodsThe 学习影响坚持的水平到 anticoagulation 治疗 111 个 AF 病人(吝啬的年龄, 73.5 ±8.3 年) 与 OAC 对待。认知功能用微型心理州的考试(MMSE ) 被估计。坚持的水平被 8 条款 Morisky 药坚持规模(MMAS-8 ) 估计。从 0 ~ 8 在 MMAS-8 范围上得分,与分数 <6 思考低坚持, 6 到 <8 中等坚持,和 AF 病人的 8 高 adherence.Results46.9% 有低坚持, 18.8% 有的中等坚持,和 33.3% 有的高坚持到 OAC。有更低的坚持的病人是比有中等或高的坚持的那些老的(76.6 ±8.7 对 71.3 ±6.4 对 71.1 ±6.7 年) 并且获得的低 MMSE 分数,显示的认知混乱或痴呆(MMSE = 22.3 ±4.2 ) 。有中等或高的坚持的病人获得了高 MMSE 测试结果(27.5 ±1.7 和 27.5 ±3.6 ) 。根据枪兵等级关联,到有 OAC 的治疗的更坏的坚持被老年决定(r S =− 0.372 ) 并且更低的 MMSE 分数(r S = 0.717 ) 。根据 multivariate 回归分析,认知功能的水平是坚持的一个重要独立预言者(b = 1.139 ).ConclusionsCognitive 缺陷是对在有 AF 的老病人的药理学治疗的依从的一个独立决定因素。出乎对认知功能的评价之外,更低的坚持与病人的年龄有关。 | Beata Jankowska-Polanska Lomper Katarzyna Alberska Lidia Jaroch Joanna Krzysztof Dudek Uchmanowicz Izabella | 2016 | Journal of Geriatric Cardiology2016，13，7： | 6 |
| 2 | Synthesis of new glycerol - based hyperbranched polycarbonates 显示文摘 | Parzuchowski P G Jaroch M | 2008 | Macromolecules2008，41，： | 1 |
| 3 | Asymmetric organocatalysis 显示文摘 | Jaroch S Weinmann H Zeitler K | 2007 | ChemMedChem2007，2，： | 1 |
| 4 | The natural history of splenic infarction显示文摘 | Jaroch M T Broughan T A Hermann R E | 1986 | Surgery1986，100，4： | 1 |
| 5 | The relationship of carotid arterial stiffness to left ventricular diastolic dysfunction in untreated hypertention显示文摘 | Jaroch J Loboz GK Bociaga Z | 2012 | Kardiol Pol2012，70，3： | 1 |
| 6 | The relationship of carotid arterial stiffness to left ventricular diastolic dysfunction in untreated hypertension显示文摘 | Jaroch J Loboz Grudzie(n) K Bociaga Z | | 0，，3： | 1 |
| 7 | Oscillatory glucose flux in INS 1 pancreatic 13 cells: a self-referencing microbiosensor study显示文摘 | Shi J McLamore ES Jaroch D | 2011 | Anal Biochem2011，411，2： | 1 |
| 8 | CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives显示文摘 | Shou-Fu Lu Binglong Chen Dave Davey Laura Dunning Stefan Jaroch Karen May James Onuffer Gary Phillips Babu Subramanyam Jih-Lie Tseng Robert G. Wei Ming Wei Bin Ye | 2007 | Bioorganic & Medicinal Chemistry Letters2007，，7： | 1 |
| 9 | The relationship of carotid arterial stiffness to left ventricular diastolic dysfunction in untreated hypertension显示文摘 | Jaroch J Loboz Grudzień K Bociaga Z | | 0，，03： | 1 |
| 10 | ROLE OF NEURONAL NITRIC OXIDE SYNTHASE IN OVINE SEPSIS MODEL显示文摘 | Perenlei Enkhbaatar Matthias Lange Yoshimitsu Nakano Atsumori Hamahata Collette Jonkam Jianpu Wang Stefan Jaroch Lillian Traber David Herndon Daniel Traber | 2009 | Shock2009，，3： | 1 |
| 11 | Self-Referen- cing Optrodes for Measuring Spatially Resolved, Real-Time Meta- bolic Oxygen Flux in Plant Systems 显示文摘 | MCLAMORE E S JAROCH D C HATNI M R | 2010 | Planta2010，232，5： | 1 |
| 12 | Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury显示文摘 | Perenlei Enkhbaatar Rhykka Connelly Jianpu Wang Yoshimitsu Nakano Matthias Lange Atsumori Hamahata Eszter Horvath Csaba Szabo Stefan Jaroch Peter H?lscher Margrit Hillmann Lillian D. Traber Frank C. Schmalstieg David N. Herndon Daniel L. Traber | 2009 | Critical Care Medicine2009，，1： | 1 |
| 13 | The natural history of splenic infarction显示文摘 | Jaroch MT Broughan TA Hermann RE | 1986 | Surgery1986，100，4： | 1 |
| 14 | The natural histort' of splenic infarction显示文摘 | Jaroch MT Broughan TA Hermann Re | 1986 | Surgery1986，100，4： | 1 |
| 15 | Oscillatory glucose flux in INS 1 pancreatic 13 ,:ells: a self referencing micro- biosensor study显示文摘 | Shi J McLamore ES Jaroch D | 2011 | Anal Biochem2011，411，2： | 1 |
| 16 | Parathyroid horone assay, 显示文摘 | Broughan TA Jaroch MT Esselstyn CB | 1986 | Arch Surg1986，121，： | 1 |
| 17 | The relationship of carotid arterial stiffness to left ventricular diastolic dysfunction in untreated hypertension显示文摘 | Jaroch J (L)oboz GK Boci(a)ga Z | | 0，，： | 1 |
| 18 | Predictors of left atrial appendage thrombogenie milieu in patients sub- jected to transesophageal echoeardiography prior to cardiover- sion of persistent atrial fibrillation显示文摘 | Jaroch J Kamifiska-Kegel A Brzeziflska B | 2016 | Pol Arch Med Wewn2016，126，12： | 1 |
| 19 | Time-course monitoring of in vitro biotransformation reaction via solid-phase microextraction-ambient mass spectrometry approaches显示文摘The solid-phase microextraction technique quantifies analytes without considerably affecting the sample composition.Herein,a proof-of-concept study was conducted to demonstrate the use of coated probe electrospray ionization(coated-PESI)and coated blade spray(CBS)as ambient mass spectrometry approaches for monitoring drug biotransformation.The ability of these methods was investigated for monitoring the dephosphorylation of a prodrug,combretastatin A4 phosphate(CA4P),into its active form,combretastatin A4(CA4),in a cell culture medium supplemented with fetal bovine serum.The CBS spot analysis was modified to achieve the same extraction efficiency as protein precipitation and obtained results in 7 min.Because coated-PESI performs extraction without consuming any samples,it is the preferred technique in the case of a limited sample volume.Although coated-PESI only extracts small quantities of analytes,it uses the desorption solvent volume of 5-10 pL,resulting in high sensitivity,thus allowing the detection of compounds after only 1 min of extraction.The biotransformation of CA4P into CA4 via phosphatases occurs within the simple matrix,and the proposed sample preparation techniques are suitable for monitoring the biotransformation. | Karol Jaroch Janusz Pawliszyn | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 0 |
| 20 | The European lead factory-an experiment in collaborative drug discovery显示文摘The European Lead Factory (ELF) is a unique collaborative public-private partnership aiming to deliver innovative drug discovery starting points and improving the value generated by ultra-High Throughput Screening (uHTS) approaches. Composed of a unique compound collection derived from private pharmaceutical company collections and complemented with new chemistries from a unique public collection, it offers a unique uHTS platform accessible to both private companies and publicly funded researchers. One of the key challenges in setting up ELF has been to balance access to screening results with protecting the value of compounds in the collection. Through an 'honest data broker' data management platform and a royalty reward scheme based on achieved milestones, ELF has been able to overcome these challenges. Set up in 2013, it has already accepted 42 targets for screening, submitted by publicly funded researchers, and generated 12 Qualified Hit Lists. In addition, 55,000 new library compounds have been generated by the public partners and added to the 320,000 compounds made available by the companies. Although it faced many challenges in becoming operational, this unique experiment in collaboration is already generating exciting results that will hopefully, eventually lead to better medicines and tools to advance our biological knowledge, and should act as a template for future approaches in the area. | Hugh Laverty Kristina Maria Orrling Fabrizio Giordanetto Magali Poinot Eckhard Ottow Ton Wilhelmus Rijnders Dimitrios Tzalis Stefan Jaroch | 2015 | Journal of Medicines Development Sciences2015，1，1： | 0 |
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