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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs显示文摘 | Xian Chen Jason S Cordes Jenifer A | 2006 | Pharmacol Toxicol Methods2006，54，3： | 1 |
| 5 | 显示文摘 | Sarah S W Donia B Jason A S | 2003 | Chemical Engi- neering Journal2003，95，1： | 1 |
| 6 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 7 | Protein microarray technology显示文摘 | David A H Jason P Michael S | 2007 | Mech Ageing Dev2007，128，1： | 1 |
| 8 | Synthesis and luminescent properties of Mn2+-doped zinc silicate phosphors by sol-gel methods显示文摘 | COPELAND THOMAS S LEE BURT I QI JASON ELROD A K | 2002 | J Lumin2002，97，： | 1 |
| 9 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 10 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 11 | Cost effectiveness analysis oflaparoscopic hysterectomy compared with standard hysterectomy; results from a randornised trial显示文摘 | Mark S Andrea M Jason A | 2004 | BMJ2004，328，： | 1 |
| 12 | HIV-1 v-inducedapoptosis is cell cycle dependent and requires Bax but not ant显示文摘 | JOSHUA L A JASON L ERIK S Z | 2006 | J Pathog2006，2，12： | 1 |
| 13 | Impact of bi- lateral versus single lung transplantation on survival in recipi- ents 60 years of age and older: Analysis of United Network for Organ Sharing database 显示文摘 | Lois U N Christopher E S Jason A W | 2007 | Thorac Cardiovasc Surg2007，133，： | 1 |
| 14 | Estimating the prevalence of chronic fatigue syndrome among nurse显示文摘 | Jason L A Wagner L Rosenthal S | 1998 | AM J Med1998，105，3： | 1 |
| 15 | Evidence for multiple mechanisms of toxicity in larval rainbow trout(Oncorhynchus mykiss)cotreated with retene and α-naphthoflavone显示文摘 | Jason A S Peter V H | 2008 | Aquatic Toxicology2008，28，3： | 1 |
| 16 | A role for the adenomatous polyposis coil protein in chromosome segregation 显示文摘 | KENNETH B K AURORA A B JASON R S | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 17 | Synthesis and characterization of non-leaching biocidal polyurethanes 显示文摘 | Jason A G Cooper S L | 2001 | Biomaterial2001，23，： | 1 |
| 18 | Targeting fibroblast activa-tion protein inhibits tumor stromagenesis and growth in mice显示文摘 | Angelica S Jason J Nazneen A | 2009 | J Clin Invest2009，119，12： | 1 |
| 19 | Molecular clocks and the origin(s) of modern amphibians 显示文摘 | MICHAEL S Y L JASON S A | 2006 | Mol Phylogenet Evol2006，0，： | 1 |
| 20 | Video-Assisted Transumbilical Meckel’s Diverticulectomy in Children显示文摘 | Clark Jason M Koontz Curt S Smith Lisa A Kelley Joseph E | 2008 | The American Surgeon2008，，4： | 1 |
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