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| 1 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 2 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 3 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Skin biomechanics:a potential therapeutic intervention target to reduce scarring显示文摘Pathological scarring imposes a major clinical and social burden worldwide.Human cutaneous wounds are responsive to mechanical forces and convert mechanical cues to biochemical signals that eventually promote scarring.To understand the mechanotransduction pathways in cutaneous scarring and develop new mechanotherapy approaches to achieve optimal scarring,the current study highlights the mechanical behavior of unwounded and scarred skin as well as intra-and extracellular mechanisms behind keloid and hypertrophic scars.Additionally,the therapeutic interventions that promote optimal scar healing by mechanical means at the molecular,cellular or tissue level are extensively reviewed.The current literature highlights the significant role of fibroblasts in wound contraction and scar formation via differentiation intomyofibroblasts.Thus,understanding myofibroblasts and their responses to mechanical loading allows the development of new scar therapeutics.A review of the current clinical and preclinical studies suggests that existing treatment strategies only reduce scarring on a small scale after wound closure and result in poor functional and aesthetic outcomes.Therefore,the perspective of mechanotherapies needs to consider the application of both mechanical forces and biochemical cues to achieve optimal scarring.Moreover,early intervention is critical in wound management;thus,mechanoregulation should be conducted during the healing process to avoid scar maturation.Future studies should either consider combining mechanical loading(pressure)therapies with tension offloading approaches for scar management or developing more effective early therapies based on contraction-blocking biomaterials for the prevention of pathological scarring. | Motaharesadat Hosseini Jason Brown Kiarash Khosrotehrani Ardeshir Bayat Abbas Shafiee | 2022 | Burns & Trauma2022，10，1： | 3 |
| 5 | Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells显示文摘 | Liu Yang Ying Wang Hua Mao Susanne Fleig Alessia Omenetti Kevin D. Brown Jason K. Sicklick Yin-Xiong Li Anna Mae Diehl | 2007 | Journal of Hepatology2007，，： | 2 |
| 6 | eVALuate研究:经腹腔镜与开腹和经阴道子宫切除术相比较的两项平行随机试验显示文摘 | Ray Garry Jayne Fountain Su Mason Jeremy Hawe Vicky Napp Jason Abbott Richard Clayton Graham Phillips Mark Whittaker Richard Lilford Stephen Bridgman Julia Brown 曹冬焱 | 2005 | 英国医学杂志中文版2005，8，3： | 2 |
| 7 | Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models显示文摘 | Ryan B. Corcoran Katherine A. Cheng Aaron N. Hata Anthony C. Faber Hiromichi Ebi Erin M. Coffee Patricia Greninger Ronald D. Brown Jason T. Godfrey Travis J. Cohoon Youngchul Song Eugene Lifshits Kenneth E. Hung Toshi Shioda Dora Dias-Santagata Anurag Sin | 2013 | Cancer Cell2013，，： | 2 |
| 8 | Incorporation of polarization into the DIRSIG synthetic image generation model 显示文摘 | Jason P M eyers John R Schott Scott D Brown | 2002 | Proceedings of SPIE(S0277-786X)2002，4816，： | 1 |
| 9 | Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells显示文摘 | Jason Yat-Sing Leung Mary Mah-Lee Ng Justin Jang Hann Chu Jay C. Brown | 2011 | Advances in Virology2011，，： | 1 |
| 10 | Central venous pressure and shock index predict lack of hemodynamic response to volume expansion in septic shock: A prospective, observational study显示文摘 | Michael J. Lanspa Samuel M. Brown Eliotte L. Hirshberg Jason P. Jones Colin K. Grissom | 2012 | Journal of Critical Care2012，，： | 1 |
| 11 | What is fa-tigue? Pathological and nonpathological fatigue 显示文摘 | Jason LA Evans M Brown M | 2010 | PM R2010，2，5： | 1 |
| 12 | Illness dur-ation and coping style in chronic fatigue syndrome显示文摘 | Molly M Brown Abigail A Brown Leonard A Jason | 2010 | PsycholRep2010，106，2： | 1 |
| 13 | What is fatigue? Pathological and nonpathological fatigue显示文摘 | Jason LA Evans M Brown M | 2010 | PMR2010，2，5： | 1 |
| 14 | Fatigue scales and chronic fatigue syndrome:issues of sensitivity and specificity显示文摘 | Jason LA Evans M Brown M | 2011 | Disabil Stud Q2011，31，1： | 1 |
| 15 | Cognitive enhancing effects of ghrelin receptor agonists显示文摘 | Zeenat Atcha Woei-Shin Chen Agnes B. Ong Fong-Kuan Wong Aveline Neo Edward R. Browne Jason Witherington Darrel J. Pemberton | 2009 | Psychopharmacology2009，，3： | 1 |
| 16 | Genome - wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization 显示文摘 | JASON M CASOLARI CHRISTOPHER R BROWN PAMELA A SILVER | 2004 | Cell2004，117，4： | 1 |
| 17 | Early pulmonary toxicity following lung stereotactic body radiation therapy delivered in consecutive daily fractions显示文摘 | Michael C. Stauder O. Kenneth Macdonald Kenneth R. Olivier Jason A. Call Kyle Lafata Charles S. Mayo Robert C. Miller Paul D. Brown Heather J. Bauer Yolanda I. Garces | 2011 | Radiotherapy and Oncology2011，，2： | 1 |
| 18 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 1 |
| 19 | Broad Spectrum Respiratory Pathogen Analysis of Throat Swabs from Military Recruits Reveals Interference Between Rhinoviruses and Adenoviruses显示文摘 | Zheng Wang Anthony P. Malanoski Baochuan Lin Nina C. Long Tomasz A. Leski Kate M. Blaney Christian J. Hansen Jason Brown Michael Broderick David A. Stenger Clark Tibbetts Kevin L. Russell David Metzgar | 2010 | Microbial Ecology2010，，4： | 1 |
| 20 | Pharmacologic management of neovascular age-related macular degeneration: systematic review of economic evidence and primary economic evaluation显示文摘 | William Hodge Allan Brown Steve Kymes Alan Cruess Gord Blackhouse Robert Hopkins Lynda McGahan Sanjay Sharma Irene Pan Jason Blair David Vollman Andra Morrison | 2010 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2010，，3： | 1 |
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