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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 3 | Enhanced cellular accumulation of a P-glycoprotein substrate,rhodamine-123,by caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers显示文摘 | Jason Z John J Mandeep B | 2002 | Euro J Phar and Biopharmaceutics2002，54，3： | 1 |
| 4 | Ligand Design and Self-Recognition: A Copper (II) Complex that Dimerizes Via Hydrogen Bonds显示文摘 | Darren J B Jason R T | 2002 | Inorganica Chimica Acta2002，341，： | 1 |
| 5 | Cholera transmission:the host,pathogen and bacteriophage dynamic显示文摘 | Eric J Nelson Jason B Harris J Glenn Morris Jr | 2009 | Journal Reviews Microbiology2009，7，： | 1 |
| 6 | Vasoconstriction in exercising skeletal muscles : a potential role for neuropeptide Y 显示文摘 | John B Buckwaher Jason J | 2004 | Am J Physiol Heart Circ Physio12004，287，： | 1 |
| 7 | Ipilimumab forpatients with advanced mucosal melanoma 显示文摘 | Michael A P Jason J L Ma r k J B | 2013 | Oncologist2013，18，6： | 1 |
| 8 | Longitudinal variation in muscle protein expression and contraction kinetics of largenmuth bass axial muscle 显示文摘 | TIERNEY M T JASON M B DAVID J C | 2001 | Journal of Experimental Biology2001，204，24： | 1 |
| 9 | Quasi-continuous dynamic traffic assignment model显示文摘 | Jason B N Robles J | 1995 | Transportation Re- search Record1995，1493，： | 1 |
| 10 | Preserving natural features:a GIS-based evaluation of a local open-space ordinance显示文摘 | JASON J T DANIEL G B LAR ISSA L | 2007 | Landscape and Urban Planning2007，82，12： | 1 |
| 11 | Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/ lpr mice显示文摘 | Knight Jason S Subramanian Venkataraman O’Dell Alexander A Yalavarthi Srilakshmi Zhao Wenpu Smith Carolyne K Hodgin Jeffrey B Thompson Paul R Kaplan Mariana J | 2015 | Annals of the Rheumatic Diseases2015，，： | 1 |
| 12 | Enhanced CO2 separation selectivity in oligo (ethylene glycol) functionalized room-temperature ionic liquids显示文摘 | JASON E B CHRISTOPHER J G SONJA L | 2007 | Ind Eng Chem Res2007，46，16： | 1 |
| 13 | Natural history of established low grade cervical intraepithelial(CIN) lesions显示文摘 | Nisha B Jason DW Carmel J | 2008 | Anticancer Res2008，28，25： | 1 |
| 14 | A review of routing and wavelength assignment approaches for wavelength-routed optical WDM networks显示文摘 | ZANG Hui JASON J MUKHERJEE P B | 2000 | SPIE Optical Networks Magazine2000，1，1： | 1 |
| 15 | Human and machine consonant recognition显示文摘 | Jason J S Louis D B | 2004 | Speech Communication2004，45，： | 1 |
| 16 | The effect of employee trust of the supervisor on enterprising behavior:a cross-cultural comparison显示文摘 | ROBERT C D RICHARD I C JASON B J SELIM I S ET AL | 2006 | Journal of Business and Psychology2006，，21： | 1 |
| 17 | A Multi-dimensional Study of Trust in Organization显示文摘 | Robert D C Selim S I Jason J B | 1998 | Journal of Managerial Issue1998，10，： | 1 |
| 18 | Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus显示文摘 | Knight Jason S Zhao Wenpu Luo Wei Subramanian Venkataraman O’Dell Alexander A Yalavarthi Srilakshmi Hodgin Jeffrey B Eitzman Daniel T Thompson Paul R Kaplan Mariana J | 2013 | Journal of Clinical Investigation2013，，： | 1 |
| 19 | 显示文摘 | Davis Jason J Coleman Karl S Bagshaw Claire B | 2002 | J Am Chem Soc2002，124，12： | 1 |
| 20 | Copper radionuclides and radiopharmaeeutieals in nuclear medicine显示文摘 | Philip J B Jason S L Jamal Z | 1996 | Nuclear Medicine & Biology1996，23，： | 1 |
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