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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Complicatons of ERCP 显示文摘 | J Shawn Mallery Todd H Baron Jason A Kom initz | 2003 | American Society For Gastrointestinal Endoscopy2003，57，6： | 1 |
| 4 | Electrospun polyacrylonitrile nanofibers containing a high concentration of wel -aligned multiwal carbon nanotubes显示文摘 | Haoqing H Ge Jason J Jun Z | | 0，，05： | 1 |
| 5 | Characterization of Crash-Induced Thoracic Loading Resulting in Pulmonary Contusion显示文摘 | F Scott Gayzik R Shayn Martin H Clay Gabler J Jason Hoth Stefan M. Duma J Wayne Meredith Joel D. Stitzel | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，3： | 1 |
| 6 | 显示文摘 | Jason J G Hou H Q Qing Li | 2004 | J Am Chem Soe2004，126，15： | 1 |
| 7 | Effect of electrogram characteristics on the relationship of dominant frequency to atrial activation rate in atrial fibrillation显示文摘 | Jason Ng Kadish A H Goldberger J J | 2006 | Heart Rhythm2006，3，10： | 1 |
| 8 | A Study of an ecnomic production-shipment policy for a single-buyer systerm 显示文摘 | Pan C H Jason Yang J S | 2000 | European Journal of Operational Research2000，121，： | 1 |
| 9 | Cytoreductive Surgery with Intraperitoneal Hyperthermic Chemotherapy for advanced Cancer显示文摘 | Jason J H Brian W L Parry S | 2004 | The Society for Surgery of the Alimentary Tract2004，8，4： | 1 |
| 10 | Land clearing and the biofuel carbon debt显示文摘 | Fargione J Jason H David T | 2008 | Science2008，319，5867： | 1 |
| 11 | 显示文摘 | Jason H Hafner Michael J Bronikowski Bobak R Azamian | 1998 | Chem Phys Lett1998，296，： | 1 |
| 12 | HPLC analysis of plant DNA methylation:a study of critical methodological factors显示文摘 | Jason J W Harding K Bremner D H | 2005 | Plant Physiology and Biochemistry2005，43，9： | 1 |
| 13 | Protein electrochemistry at carbon nanotube electrodes 显示文摘 | Jason J Davis Richard J Coles H Allen O Hill | 1997 | Journal of Electroanalytical Chemistry1997，440，： | 1 |
| 14 | 显示文摘 | Hou H Jason J G Zeng J | 2005 | Chemistry of Materials2005，17，5： | 1 |
| 15 | Electrospun polyacrylonitrile nanofibers containing a high concentration of well-aligned multiwall carbon Nanotubes 显示文摘 | Hou H Q Jason J Ge Zeng J Li Q Reneker D H Greiner A Cheng S Z D | 2005 | Chem Mater2005，17，： | 1 |
| 16 | Eleetrospun polyacrylonitrile nanofibers containing a high concentration of well-aligned multiwall carbon nanotubes 显示文摘 | Hou H Jason J G Zeng J | 2005 | Chemistry of Materials2005，17，5： | 1 |
| 17 | Assembly of well-aligned muhiwalled carbon nanotubes in confined polyacrylonitrile environments: electrospun composite nanofiber sheets 显示文摘 | Jason J G Hou H Li Q | 2004 | American Chemical Society2004，126，15： | 1 |
| 18 | Thefrequency,complications and aetiology of ADHD in new onset pae-diatric epilepsy显示文摘 | Bruce H Jana J Kevin D Chase AA Raj S Jason F | 2007 | Brain2007，130，12： | 1 |
| 19 | The Mycobacterium avium subsp, paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells 显示文摘 | Bannantine J P Jason F J H Elizabeth M | 2003 | Microbiology2003，149，： | 1 |
| 20 | Survivable self-organization for prolonged lifetime in wireless sensor networks显示文摘 | Mohammad M H and Jason P J | 2011 | International Journal of Distributed Sensor Networks2011，2011，1： | 1 |
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