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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 3 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 3 |
| 4 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 2 |
| 5 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 6 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 7 | Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen‐positive hepatocellular carcinoma: a comparison with chronic carriers显示文摘 | Myron J.Tong Lawrence M.Blatt Jia‐HorngKao Jason TzuyingCheng William G.Corey | 2007 | Liver International2007，，10： | 2 |
| 8 | Physicochemical changes in intermediate-moisture protein bars made with whey protein or calcium caseinate显示文摘 | Simon M. Loveday Jason P. Hindmarsh Lawrence K. Creamer Harjinder Singh | 2010 | Food Research International2010，，5： | 1 |
| 9 | Association Between Human Immunodeficiency Virus Infection and Stiffness of the Common Carotid Artery显示文摘 | Eric C. Seaberg Lorie Benning A. Richey Sharrett Jason M. Lazar Howard N. Hodis Wendy J. Mack Mark J. Siedner John P. Phair Lawrence A. Kingsley Robert C. Kaplan | 2010 | Stroke2010，，10： | 1 |
| 10 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 11 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 1 |
| 12 | A distinct urban biogeochemistry?显示文摘 | Jason P. Kaye Peter M. Groffman Nancy B. Grimm Lawrence A. Baker Richard V. Pouyat | 2006 | Trends in Ecology & Evolution2006，，4： | 1 |
| 13 | Radial-motion assisted command shapers for nonlinear tower crane rotational slewing 显示文摘 | DAVID BLACKBURN JASON LAWRENCE JON DANIELSON | 2010 | Control Engineea4ng Practice2010，18，5： | 1 |
| 14 | Devel- opment and application of a muhimodal contrast ggent for SPECT/CT hybrid imaging 显示文摘 | Jason M C Lawrence W D Zhen W Z etal | 2011 | Bioconjug Chem2011，22，： | 1 |
| 15 | Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair显示文摘 | Tasneem Kausar Jason S. Schreiber David Karnak Leslie A. Parsels Joshua D. Parsels Mary A. Davis Lili Zhao Jonathan Maybaum Theodore S. Lawrence Meredith A. Morgan | 2015 | Neoplasia2015，，10： | 1 |
| 16 | Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a coronin-1A mutation and a chromosome 16p11.2 deletion显示文摘 | Lawrence R. Shiow Kenneth Paris Matthew C. Akana Jason G. Cyster Ricardo U. Sorensen Jennifer M. Puck | 2008 | Clinical Immunology2008，，1： | 1 |
| 17 | Prospective Study of Intravitreal Ranibizumab as a Treatment for Decreased Visual Acuity Secondary to Central Retinal Vein Occlusion显示文摘 | Richard F. Spaide Louis K. Chang James M. Klancnik Lawrence A. Yannuzzi John Sorenson Jason S. Slakter K. Bailey Freund Robert Klein | 2009 | American Journal of Ophthalmology2009，，2： | 1 |
| 18 | Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor-Deficient Mice显示文摘 | Michael E Burleigh Vladimir R Babaev John A Oates Raymond C.Harris Shiva Gautam Denis Riendeau Lawrence J.Marnett Jason D.Morrow Sergio Fazio MacRae F.Linton | | 0，，15： | 1 |
| 19 | Ophthalmic Fundus Imaging:Today and Beyond 显示文摘 | LAWRENCE A MICHAEL D JASON S | 2004 | American journal of ophthalmology2004，137，3： | 1 |
| 20 | On the temporal upscaling of evapotranspiration from instantaneous remote sensing measurements to 8-day mean daily-sums显示文摘 | Youngryel Ryu Dennis D. Baldocchi T. Andrew Black Matteo Detto Beverly E. Law Ray Leuning Akira Miyata Markus Reichstein Rodrigo Vargas Christof Ammann Jason Beringer Lawrence B. Flanagan Lianhong Gu Lindsay B. Hutley Joon Kim Harry McCaughey Eddy J. Moor | 2011 | Agricultural and Forest Meteorology2011，，： | 1 |
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