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| 1 | Th17 plasticity and its changes associated with inflammatory bowel disease显示文摘CD4 T helper(Th) cell differentiation into distinct T cell subsets is critical to the normal function of the immune system. Until recently,the paradigm held that na?ve T cells differentiated into distinct subsets under the guidance of environmental cues(e.g.,cytokines) and that once polarized,these cells were committed to a particular functional state. However,the existence of transdifferentiated T cell populations,which express signature transcription factors and cytokines associated with more than one Th subset,challenges the immutability of T helper subsets and suggests that plasticity is a feature of multifaceted immune responses. How this process impacts immune dysregulation in diseases such as inflammatory bowel diseases(IBD) and the machinery that underlies this process is far from fully understood. Interleukin(IL)-17 secreting helper T(Th17) cells have been heavily implicated in tissue-specific immune pathology including murine models of IBD,human Crohn's disease and ulcerative colitis. Plasticity within this subset is suggested by the existence of IL-17 secreting cells,which,can also secrete interferon-γ,the signature cytokine for Th1 cells or,can co-express the anti-inflammatory transcription factor forkhead box p3,a signature transcription factor of regulatory T cells. In this review we mainly discuss evidence for Th17 plasticity,mechanisms,which govern it,and highlight the potential to therapeutically target this process in human IBD. | Aito Ueno Abhisek Ghosh Daniel Hung Ji Li Humberto Jijon | 2015 | World Journal of Gastroenterology2015，21，43： | 23 |
| 2 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 2 |
| 3 | Mechanisms of omega - 3 fatty acid - induced growth inhibition in MDA - MB- 231 human breast cancer ceils 显示文摘 | SCHLEY P D JIJON H B ROBINSON L E | 2005 | Breast Cancer Res Treat2005，92，2： | 1 |
| 4 | Human small bowel storage: the role for luminal preservation solutions 显示文摘 | Olson DW Jijon H Madsen KL | 2003 | Transplantation2003，76，4： | 1 |
| 5 | Managing vaginal mesh exposure/erosions显示文摘 | Davila G W Jijon A | 2012 | Curr Opin Obstet Gynecol2012，24，5： | 1 |
| 6 | Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function显示文摘 | Karen Madsen Anthony Cornish Paul Soper Conor McKaigney Humberto Jijon Christine Yachimec Jason Doyle Lawrence Jewell Claudio De Simone | 2001 | Gastroenterology2001，，3： | 1 |
| 7 | Managing vaginal mesh exposure/erosions 显示文摘 | Davila G W Jijon A | 2012 | Curr Opin Obstet Gyneco12012，24，5： | 1 |
| 8 | DNA from probiotic bacteria modulate murine and human eithelial and immune functions显示文摘 | Jijon H Backer J Diaz H | 2004 | Gastroenterology2004，126，4： | 1 |
| 9 | Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells显示文摘 | Jijon HB Walker J Hoentijen F | | 0，，02： | 1 |
| 10 | Increased preva- lence of circulating novel IL-17 secreting Foxp3 ex- pressing CD4+ T cells and defective suppressive func- tion of circulating Foxp3-k regulatory cells support plasticity between Thl7 and regulatory T cells in in- flammatory bowel disease patients显示文摘 | UENO A JIJON H CHAN R | 2013 | Inflamm Bowel Dis2013，19，： | 1 |
| 11 | Mechanisms of omega 3 fatty acid induced growth inhibition in MDA MB231 human breast cancer cells显示文摘 | Schley P D Jijon H B Robinson L E | 2005 | Breast Cancer Research and Treatment2005，92，18： | 1 |
| 12 | NF-kappa B inducing kinase activates NF-kappa B transcriptional activity in- dependently of IkappaB kinase gamma through a p38 MAPK2 dependent RelA phosphorylation path-way 显示文摘 | JIJON H ALLARD B JOBIN C | 2004 | Cell Signal2004，16，： | 1 |
| 13 | Atgl6L1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection 显示文摘 | Conway KL Kuballa P Song JH Patel KK Castoreno AB Yilmaz OH Jijon HB Zhang M Aldrich LN Villa- blanca El Peloquin JM Goel G Lee IA Mizoguchi E Shi HN Bhan A_K Shaw SY Schreiber SL Virgin HW Shamji AF Stappenbeck TS Reinecker HC Xavier RJ | 2013 | Gastroenterology2013，145，6： | 1 |
| 14 | Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells显示文摘 | Schley PD Jijon HB Robinson LE | 2005 | Breast Cancer Res Treat2005，92，2： | 1 |
| 15 | Increased prevalence of circulating no- vel IL-17 secreting Foxp3 expressing CD4 - T cells and defective sup- pressi'Je function of circulating Foxp3 + reegulator,j eels suppot plastici- ty between Thl7 and regulatory T cells in inflammatory bowel disease patients显示文摘 | Ueno A Jijon H Chan R | 2013 | Inflamm Bowel Dis2013，19，12： | 1 |
| 16 | NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB kinase gamma through a p38 MAPK-dependent RelA phosphorylation pathway显示文摘 | Jijon H Allard B Jobin C | 2004 | Cell Signal2004，16，9： | 1 |
| 17 | NF-kappaB inducing ki-nase activates NF-kappaB transcriptional activity inde-pendently of IkappaB kinase gamma through a p38MAPK2 dependent RelA phosphorylation path-way 显示文摘 | Jijon H Allard B and jobin C | 2004 | CeU Signal2004，16，9： | 1 |
| 18 | NF-κB induction kinase activates NF-κB transcriptional activity independently of lnB kinase through a P38 MAPK-dependent RelA phosphorylation pathway 显示文摘 | Jijon H Allard B Jobin C | 2004 | Science2004，45，16： | 1 |
| 19 | The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8secretion in intestinal epithelial cells显示文摘 | JIJON H B BURET A HIROTA C L | 2012 | Mediators Inflamm2012，2012，20： | 1 |
| 20 | Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells 显示文摘 | Schley PD Jijon HB Robinson LE | 2005 | Breast Cancer Res Treat2005，92，2： | 1 |
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