|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Analytic solution for MHD rotating flow of a second grade fluid over a shriking surface显示文摘 | Hayat T Javad T Sajid M | 2008 | Physics Letters A2008，372，18： | 1 |
| 3 | Changes in the gonial angle following bilateral sagittal split osteotomy and vertical ramus osteotomy for mandibular excess 显示文摘 | JAVAD Y KOUROSH T MOHAMMAD H K M | 2010 | Eplasty2010，10，： | 1 |
| 4 | A Novel Spherical Parallel Manipulator:Forward Position Problem,Singularity Analysis and lsotropy Design显示文摘 | Javad E Alireza A T | | 0，，5： | 1 |
| 5 | Effect of extreme hypercapnia on hypoxic - ischemic brain damage in the immature rat显示文摘 | Vannucci RC Javad T Robert M | 2001 | Pediatr Res2001，49，： | 1 |
| 6 | Numerical investigation of flow in hydraulic valves with different head shapes 显示文摘 | Javad T S Siikonen T | 2013 | Asian Journal of Scientific Research2013，6，3： | 1 |
| 7 | Modified methods fo rthe synthesis of triazinyl fluorescent brightener intermedi ates显示文摘 | Javad S Mahmood T Abdolhamid B | 2003 | Molecules2003，，8： | 1 |
| 8 | A novel approach for forward position analysis of a double-triangle spherical parallel manipulator 显示文摘 | Javad E Akbarzadeh T A | 2010 | European Journal of Mechanics-A/ Solids2010，29，3： | 1 |
| 9 | Bilateral Total Hip Arthroplasty显示文摘 | Javad P David T Ednan S | 2006 | Clin Orthop Relat Res2006，45，1： | 1 |
| 10 | Total knee arthroplasty in patients with a prior fracture of the tibial plateau显示文摘 | Nicholas G W Javad P Robert T T | 2003 | J Bone Joint Surg(Am)2003，85，2： | 1 |
| 11 | Numerical and experimental investigation of seam welding with a pulsed laser显示文摘 | Jamshid S Maryam A Javad T M | 2008 | Optics and Laser Technology2008，40，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员