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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 3 | Treatment of highgrade glioma patients with the humanized anti - epidermal growth factor receptor (EGFR) antibody h - R3 : Report from a phase I/Ⅱ trial显示文摘 | Tania C R Javier F Mauricio C | 2006 | Cancer Biol Ther2006，5，4： | 1 |
| 4 | Human neural stem cell in vitro, A focus on their isolation and perpetuation 显示文摘 | Villa F Javier Rubio B Navarro C | 2001 | Bio Med Pharmacother2001，55，： | 1 |
| 5 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 6 | Strand spaces:Proving security protocols correct显示文摘 | Javier Thayer Fábrega F Jonathan C Herzog Joshua D Guttman | 1999 | Journal of Computer Security1999，7，23： | 1 |
| 7 | Xylanase production by a new alkalitolerant isolate of Bacillus显示文摘 | L'opez C Blanco A Javier Pastor F I | 1998 | Biotechnology Letters1998，20，3： | 1 |
| 8 | Kernel-oriented algorithm for transmission expansion planning显示文摘 | Javier C Felix F Wu A | 2000 | IEEE Trans on Power Systems2000，15，4： | 1 |
| 9 | Age-dependent associations between sleep-disordered breathing and hypert-ension显示文摘 | Donald C Haas Gregory L Foster F Javier Nieto | 2005 | Circulation2005，111，： | 1 |
| 10 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 11 | Auction design in day-ahead electricity markets显示文摘 | Javier C Oscar C Jose I F | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 12 | Strand spaces : Proving security protocols correct显示文摘 | Javier F Herzog J C Guttman J D | 2001 | Journal of Computer Security2001，7，： | 1 |
| 13 | Auction Design in Day-ahead Electricity Markets显示文摘 | Javier C Oscar C Jose I F | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 14 | Strand space: Proving security protocols correct 显示文摘 | Javier Thayer Fabrega F Jonathan C Herzog Joshua D Guttman | 1999 | Journal of Computer Security1999，，7： | 1 |
| 15 | Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium 显示文摘 | Javier C Susanne L Yuxi F | 2012 | Cellular Signalling2012，24，6： | 1 |
| 16 | Sistemas transcurrentes de escala litosferica en el Sur del Peru显示文摘 | Thierry S Javier J Victor C William M Conrado B Michel F Pierrick R Harmuth A Jorge A Luis C Alexander F Ivanoff I Omar L Mirian M Paola M Francis O Yovani O Adan P and Rildo R | | 0，，05： | 1 |
| 17 | DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer显示文摘 | JAVIER C F AZUARA D BERENGUER-LLERGO A | 2013 | Cancer Prevention Research2013，6，7： | 1 |
| 18 | Building trust f~om context similarity measures显示文摘 | CARMEN F C~ ISAAC A JAVIER L | 2014 | Computer Standards & Interfaces2014，36，： | 1 |
| 19 | The effect of shot blasting and heat treatment on the fatigue behavior of titanium for dental implant applications 显示文摘 | JAVIER G F PLANELL J A PADROS A APARICIO C | 2007 | Dental Materials2007，23，4： | 1 |
| 20 | Strand Spaces:Proving Security Protocols Correct显示文摘 | Javier F Herzog J C Guttman J D | 1999 | Journal of Computer Security1999，7，23： | 1 |
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