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| 1 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 2 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 3 | GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising incidence.Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement.Numerous therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and survival.Advances in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample sizes.In this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation. | Javier Luna Andrea Bobo Joaquín José Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González Ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，8： | 2 |
| 4 | Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report显示文摘 | Antonio Bayés de Luna Josep Brugada Adrian Baranchuk Martin Borggrefe Guenter Breithardt Diego Goldwasser Pier Lambiase Andrés Pérez Riera Javier Garcia-Niebla Carlos Pastore Giuseppe Oreto William McKenna Wojciech Zareba Ramon Brugada Pedro Brugada | 2012 | Journal of Electrocardiology2012，，5： | 1 |
| 5 | Gastrointestinal cytomegalovirus disease in patients with cancer: A two decade experience in a tertiary care cancer center显示文摘 | Harrys A. Torres Dimitrios P. Kontoyiannis Gerald P. Bodey Javier A. Adachi Mario A. Luna Jeffrey J. Tarrand Graciela M. Nogueras Issam I. Raad Roy F. Chemaly | 2005 | European Journal of Cancer2005，，15： | 1 |
| 6 | Role of artificial intelligence in multidisciplinary imaging diagnosis of gastrointestinal diseases显示文摘The use of artificial intelligence-based tools is regarded as a promising approach to increase clinical efficiency in diagnostic imaging,improve the interpretability of results,and support decision-making for the detection and prevention of diseases.Radiology,endoscopy and pathology images are suitable for deep-learning analysis,potentially changing the way care is delivered in gastroenterology.The aim of this review is to examine the key aspects of different neural network architectures used for the evaluation of gastrointestinal conditions,by discussing how different models behave in critical tasks,such as lesion detection or characterization(i.e.the distinction between benign and malignant lesions of the esophagus,the stomach and the colon).To this end,we provide an overview on recent achievements and future prospects in deep learning methods applied to the analysis of radiology,endoscopy and histologic whole-slide images of the gastrointestinal tract. | M Alvaro Berbís José Aneiros-Fernández F Javier Mendoza Olivares Enrique Nava Antonio Luna | 2021 | World Journal of Gastroenterology2021，27，27： | 1 |
| 7 | Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report显示文摘 | Antonio Bayés de Luna Josep Brugada Adrian Baranchuk Martin Borggrefe Guenter Breithardt Diego Goldwasser Pier Lambiase Andrés Pérez Riera Javier Garcia-Niebla Carlos Pastore Giuseppe Oreto William McKenna Wojciech Zareba Ramon Brugada Pedro Brugada | 2012 | Journal of Electrocardiology2012，，5： | 1 |
| 8 | Clinical Imaging of Tumor Metabolism with 1 H Magnetic Resonance Spectroscopy显示文摘 | Teodoro Martín Noguerol Javier Sánchez-González José Pablo Martínez Barbero Roberto García-Figueiras Sandra Baleato-González Antonio Luna | 2016 | Magnetic Resonance Imaging Clinics of North Ameri2016，，1： | 1 |
| 9 | Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report显示文摘 | Antonio Bayés de Luna Josep Brugada Adrian Baranchuk Martin Borggrefe Guenter Breithardt Diego Goldwasser Pier Lambiase Andrés Pérez Riera Javier Garcia-Niebla Carlos Pastore Giuseppe Oreto William McKenna Wojciech Zareba Ramon Brugada Pedro Brugada | 2012 | Journal of Electrocardiology2012，，5： | 1 |
| 10 | Thiopurine Methyltransferase Activity in Spain: A Study of 14,545 Patients显示文摘 | Javier P. Gisbert Fernando Gomollón Carlos Cara Marta Luna Yago González-Lama José María Pajares José Maté Luis G. Guijarro | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 11 | Clinical impact of artificial intelligence-based solutions on imaging of the pancreas and liver显示文摘Artificial intelligence(AI)has experienced substantial progress over the last ten years in many fields of application,including healthcare.In hepatology and pancreatology,major attention to date has been paid to its application to the assisted or even automated interpretation of radiological images,where AI can generate accurate and reproducible imaging diagnosis,reducing the physicians’workload.AI can provide automatic or semi-automatic segmentation and registration of the liver and pancreatic glands and lesions.Furthermore,using radiomics,AI can introduce new quantitative information which is not visible to the human eye to radiological reports.AI has been applied in the detection and characterization of focal lesions and diffuse diseases of the liver and pancreas,such as neoplasms,chronic hepatic disease,or acute or chronic pancreatitis,among others.These solutions have been applied to different imaging techniques commonly used to diagnose liver and pancreatic diseases,such as ultrasound,endoscopic ultrasonography,computerized tomography(CT),magnetic resonance imaging,and positron emission tomography/CT.However,AI is also applied in this context to many other relevant steps involved in a comprehensive clinical scenario to manage a gastroenterological patient.AI can also be applied to choose the most convenient test prescription,to improve image quality or accelerate its acquisition,and to predict patient prognosis and treatment response.In this review,we summarize the current evidence on the application of AI to hepatic and pancreatic radiology,not only in regard to the interpretation of images,but also to all the steps involved in the radiological workflow in a broader sense.Lastly,we discuss the challenges and future directions of the clinical application of AI methods. | M Alvaro Berbís Felix Paulano Godino Javier Royuela del Val Lidia AlcaláMata Antonio Luna | 2023 | World Journal of Gastroenterology2023，29，9： | 0 |
| 12 | Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor:A new paradigm?显示文摘Stereotactic ablative body radiotherapy(SABR)is an effective technique comparable to surgery in terms of local control and efficacy in early stages of non-small cell lung cancer(NSCLC)and pulmonary metastasis.Several fractionation schemes have proven to be safe and effective,including the single fraction(SF)scheme.SF is an option costeffectiveness,more convenience and comfortable for the patient and flexible in terms of its management combined with systemic treatments.The outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic has driven this not new but underutilized paradigm,recommending this option to minimize patients’visits to hospital.SF SABR already has a long experience,strong evidence and sufficient maturity to reliably evaluate outcomes in peripheral primary NSCLC and there are promising outcomes in pulmonary metastases,making it a valid treatment option;although its use in central locations,synchronous and recurrencies tumors requires more prospective safety and efficacy studies.The SABR radiobiology study,together with the combination with systemic therapies,(targeted therapies and immunotherapy)is a direction of research in both advanced disease and early stages whose future includes SF. | Castalia Fernandez Arturo Navarro-Martin Andrea Bobo Joaquin Cabrera-Rodriguez Patricia Calvo Rodolfo Chicas-Sett Javier Luna Nuria Rodriguez de Dios Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，2： | 0 |
| 13 | GOECP/SEOR clinical recommendations for lung cancer radiotherapy during the COVID-19 pandemic显示文摘The coronavirus disease 2019 crisis has had a major and highly complex impact on the clinical practice of radiation oncology worldwide.Spain is one of the countries hardest hit by the virus,with devastating consequences.There is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung cancer.In the present article,the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic. | Felipe Couñago Arturo Navarro-Martin Javier Luna Nuria Rodríguez de Dios Aurora Rodríguez Francesc Casas Rafael García Antonio Gómez-Caamaño Jorge Contreras Javier Serrano | 2020 | World Journal of Clinical Oncology2020，11，8： | 0 |
| 14 | New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer显示文摘Immunotherapy has represented one of the main medical revolutions of recent decades,and is currently a consolidated treatment for different types of tumors at different stages and scenarios,and is present in a multitude of clinical trials.One of the diseases in which it is most developed is non-small cell lung cancer.The combination of radiotherapy and immunotherapy in cancer in general and lung cancer in particular currently represents one of the main focuses of basic and clinical research in oncology,due to the synergy of this interaction,which can improve tumor response,resulting in improved survival and disease control.In this review we present the biochemical and molecular basis of the interaction between radiotherapy and immunotherapy.We also present the current clinical status of this interaction in each of the stages and cases of non-small cell lung cancer,with the main results obtained in the different studies both in terms of tumor response and survival as well as toxicity.Finally,we mention the main studies underway and the challenges of this interaction in the coming years,including how these treatments should be combined to achieve the greatest efficacy with the fewest possible side effects(dose,type of radiotherapy and drugs,sequence of treatments). | Javier Luna Juan Zafra Ma Carmen Areses Manrique Aurora Rodríguez Amalia Sotoca Jose Luis Fírvida Rodolfo Chicas-Sett Xabier Mielgo Juan Carlos Trujillo Reyes Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，11： | 0 |
| 15 | A Neuro-Fuzzy Approach for Automatic Detection of Breast Cancer Based on Raman Spectroscopy显示文摘 | Francisco Javier Luna Rosas Julio Cesar Martinez Romo Ricardo Mendoza Gonzalez Valentin Lopez Rivas Miguel Mora Gonzalez Gricelda Medina Veloz | 2014 | 通讯和计算机(中英文版)2014，11，2： | 0 |
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