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您的检索式：作者名="Jaydeep Bhat"
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| 1 | Multilayer epigenetic analysis reveals novel transcription factor networks in CD8 T cells显示文摘A characteristic feature of the adaptive immune system is immunological memory,which is the more rapid and more potent response to antigenic challenge upon re-encountering the antigen–even years after the primary antigen contact.CD8 T cells are essential players in the adaptive immune response to viruses and intracellular microbes.Upon infection,antigen-responsive naive CD8 T cells are activated and they clonally expand to give rise to sufficient effector cell numbers to execute an adequate immune response.Effector cells are deleted after the clearance of infection,but some T cells survive and are maintained as memory T cells in a non-proliferative state in secondary lymphoid tissues and bone marrow.1 Complex transcriptional programs regulate CD8 T-cell differentiation from antigen-inexperienced naive cells via the effector cell stage towards long-term memory cells. | Jaydeep Bhat Dieter Kabelitz | 2018 | Cellular & Molecular Immunology2018，15，3： | 1 |
| 2 | γδ T cells and epigenetic drugs: A useful merger in cancer immunotherapy?显示文摘 | Jaydeep Bhat Dieter Kabelitz | 2015 | OncoImmunology2015，，6： | 1 |
| 3 | DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy显示文摘The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation. | Jaydeep Bhat Anke KBergmann Silvio Waschina Christoph Nerl Christoph Kaleta Reiner Siebert Ole Ammerpohl Dieter Kabelitz | 2021 | Cellular & Molecular Immunology2021，18，5： | 0 |
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