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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Public-private partnerships and government spending limits显示文摘 | Eric M Jean T | 2008 | Internationnal Journal of Industrial Organnization2008，26，2： | 1 |
| 3 | Effects of repeated treatments with an extract of Ginkgo biloba ( EGb761 ), bilobalide and ginkgolide B on the electrical activity of pancreatic beta cells of normal or alloxan-diabetic mice: an ex vivo study with intracellular microelectrodes显示文摘 | VASSEUR M JEAN T DEFEUDIS FV | 1994 | Gen Pharmacol1994，25，1： | 1 |
| 4 | Ultra-wideband coherent processing 显示文摘 | Kevin M Cuomo Jean E Piou Joseph T Mayhan | 1997 | Lincoln Laboratory Journal1997，10，2： | 1 |
| 5 | Application of an artificial neural network for simulating robust plasma-sprayed zirconia coatings 显示文摘 | JEAN M D LIN B T CHOU J H | 2008 | Journal of the American Ceramic Society2008，91，5： | 1 |
| 6 | Ultrawideband coherent processing 显示文摘 | Kevin M Cuomo Jean E Piou Joseph T Mayhan | 1999 | IEEE Trans on Antennas and Propagation1999，47，7： | 1 |
| 7 | Market Liquidity and Performance Monitoring 显示文摘 | HOLMSTR M BENGT JEAN T | 1993 | Journal of Political Econo- my1993，，101： | 1 |
| 8 | Ultra-wideband coherent Processing显示文摘 | KEVIN M CUOMO JEAN E PIOU JOSEPH T MAY-HAN | 1997 | The Lin-coln Laboratory Journal1997，10，2： | 1 |
| 9 | Effects of repeated treatments with an extract of Ginkgo biloba ( EGb 761 ), bilobalide and ginkgolide B on the electrical activity of pancreatic beta cells of normal or alloxan-diabetic mice:an ex vivo study with intracellular microelectrodes 显示文摘 | Vasseur M Jean T DeFeudis FV | 1994 | Gen Pharma- col1994，25，1： | 1 |
| 10 | Low-Fire Processing and Proper- ties of Ferrite + Dielectric Ceramic Composite 显示文摘 | Peng T M Hsu R T Jean J H | 2006 | J Am Ceram Soc2006，89，9： | 1 |
| 11 | Comparing directand synthetie tests for intemi ption of line-charging capacitive current显示文摘 | DAIGNEAULT G JEAN GS T LANDRY M | 2001 | IEEE Transactions on Power Delivery2001，16，3： | 1 |
| 12 | Electricalpmperties of low-fire ferroelectric + ferrimagnetic ceramic composite显示文摘 | R T Hsu T M Peng J H Jean | 2006 | Japanese Journal of Applied Physics2006，45，： | 1 |
| 13 | Effect of repeated treatments with an extract of Ginkgo biloba(Egb761) bilobalide and ginkgdioke B on the electrical activity of panereatic β cells of normal or alloxan diabetic mice: an ex vivo study with intracellularv microelectrodes显示文摘 | JEAN T DEFEUDIS F V | 1994 | Gen pharmacyol1994，25，1： | 1 |
| 14 | Cancer spheres from gas- tric cancer patients provide an ideal model system for cancer stem cell research显示文摘 | Han M E Jean T Y Hwang S H | 2011 | Cell Mol Life Sci2011，68，21： | 1 |
| 15 | Modulation of HIV-1 replication by RNA interference显示文摘 | Jean M J Karine T Mario S | 2002 | Nature2002，418，： | 1 |
| 16 | A comparison of forecast performance between Federal Reserve staff forecasts, simple reduced-form models, and a DSGE model显示文摘 | Edge R M Michael T K Jean P L | 2010 | Journal of Applied Econometrics2010，25，2： | 1 |
| 17 | Synthesis, Characterization, and Miscibility of Caprolactone Random Copolymers 显示文摘 | Jean M V Robert J Philippe T | 1986 | Macromolecules1986，19，7： | 1 |
| 18 | Evidence of Atmospheric Paleocirculation over the Gulf of Guinea since the Last Glacial Maximum显示文摘 | JEAN P T | 1994 | Qua ternary Research1994，41，： | 1 |
| 19 | A methodology to design arbitrar- y failure detectors for distributed protocols 显示文摘 | Roberto B Jean M H Sara T P | 2008 | Journal of Sys- tems Architecture2008，54，7： | 1 |
| 20 | Using response surface methodologyfor optimizing deposited partially stabilized zirconia in plasma spraying显示文摘 | LIN B T JEAN M D CHOU J H | 2007 | Applied Surface Science2007，253，6： | 1 |
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