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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | Strengthen the Environmental Sense of Local Community with PRA and MIGIS显示文摘It was widely recognized that rural development especially rural development in the poor areas is closely related with environment issue. It is also common bias that farmers in the poor areas lack of environmental awareness, and their production activities directly cause the environment degradation. The study has shown that with appropriate outside facilitation. a poor rural community can not only analyze its environmental problem, but can also make feasible planning to recover the problem. | CAI Kui, MA Huan-cheng, John McDinnon, Jack McConchie, Jean McKinnon (Yunnan Institute of Geography, Kunming 650092, China, Southwest Forestry College,Kunming 650092, China, 3. School of Earth Science, Wellington-Victoria University,Wellington, New Zeal | 2000 | Journal of Geographical Sciences2000，10，2： | 5 |
| 3 | Decomposition and decoupling analysis of carbon dioxide emissions in African countries during 1984–2014显示文摘The potential for mitigating climate change is growing worldwide,with an increasing emphasis on reducing CO_(2)emissions and minimising the impact on the environment.African continent is faced with the unique challenge of climate change whilst coping with extreme poverty,explosive population growth and economic difficulties.CO_(2)emission patterns in Africa are analysed in this study to understand primary CO_(2)sources and underlying driving forces further.Data are examined using gravity model,logarithmic mean divisia index and Tapio's decoupling indicator of CO_(2)emissions from economic development in 20 selected African countries during 1984-2014.Results reveal that CO_(2)emissions increased by 2.11%(453.73 million ton)over the research period.Gravity centre for African CO_(2)emissions had shifted towards the northeast direction.Population and economic growth were primary driving forces of CO_(2)emissions.Industrial structure and emission efficiency effects partially offset the growth of CO_(2)emissions.The economic growth effect was an offset factor in central African countries and Zimbabwe due to political instability and economic mismanagement.Industrial structure and emission efficiency were insufficient to decouple economic development from CO_(2)emissions and relieve the pressure of population explosion on CO_(2)emissions in Africa.Thus,future efforts in reducing CO_(2)emissions should focus on scaleup energy-efficient technologies,renewable energy update,emission pricing and long-term green development towards sustainable development goals by 2030. | Claudien Habimana Simbi Jianyi Lin Dewei Yang Jean Claude Ndayishimiye Yang Liu Huimei Li Lingxing Xu Weijing Ma | 2021 | Journal of Environmental Sciences2021，33，4： | 3 |
| 4 | WAHLENBERGIOSIDE, A PHENYLPROPANOID GLUCOSIDE FROM WAHLENBERGIA MARGINATA 显示文摘 | WEI GUANG MA REN XIANG TAN NICOLA FUZZATI JEAN -LUC WOLFENDER | 1997 | Phytochemistry1997，45，2： | 1 |
| 5 | Interlaboratory comparison of PCR - based identification and genogrouping of Neisseria meningitides 显示文摘 | Muhamed KT Jean MA Mary C | 2005 | J Clin Microbiol2005，，： | 1 |
| 6 | A comparison of working versus nonworking family caregivers of stroke survivors显示文摘 | Jean YK Dawn MA Patricia CC | 2007 | Journal of Neuroscience Nursing2007，39，4： | 1 |
| 7 | Sectoral systems of environmental innovation: An application to the French automotive industry显示文摘 | Vanessa Oltra Ma?der Saint Jean | 2008 | Technological Forecasting & Social Change2008，，4： | 1 |
| 8 | Clinical care costing method for theclinical care classification system ( TM) 显示文摘 | Virginia KS Jean MA | 2004 | Int Nurs Termi-nol Csssif2004，15，3： | 1 |
| 9 | A comparison of working versus- non working family caregivers of stroke survivors显示文摘 | Jean YK Dawn MA Patricia CC | 2007 | Journal of Neuroscience Nursing2007，39，4： | 1 |
| 10 | Effects of combined granulocyte-macrophage colony-stimulating factor (GM-CSF),interleukin-2,and interleukin-12 based immunotherapy against intracranial glioma in the rat显示文摘 | Jean WC Spellman SR Wallenfriedman MA | 2004 | J Neuro Oncol2004，66，12： | 1 |
| 11 | Interleukin-12-based imm unotherapy againdt rat 9L glioma显示文摘 | Spellman SR Wallenfriedman MA | 1998 | Neurosurgery1998，42，4： | 1 |
| 12 | Variety of technological trajectories in low emission vehicles (LEVs) : A patent data analysis 显示文摘 | Vanessa Oltra Ma? der Saint Jean | 2009 | Journal of Cleaner Production2009，，17： | 1 |
| 13 | Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials显示文摘 | Mark T Dransfield Jean Bourbeau Paul W Jones Nicola A Hanania Donald A Mahler J?rgen Vestbo Andrew Wachtel Fernando J Martinez Frank Barnhart Lisa Sanford Sally Lettis Courtney Crim Peter MA Calverley | 2013 | The Lancet Respiratory Medicine2013，，3： | 1 |
| 14 | Outcomes of HIV-infected patients treated for recurrent tuberculosis with the standard retreatment regimen 显示文摘 | McGreevy J Jean Juste MA Severe P | 2012 | Int J Tuberc Lung Dis2012，16，6： | 1 |
| 15 | Hydraulic Darrieus Turbines Efficiency for Free Fluid Flow Conditions Versus Power Farms Conditions显示文摘 | Sylvain Antheaume Thierry Ma Rre Jean - Luc Achard | 2008 | Renewable Energy2008，33，10： | 1 |
| 16 | Paleomagnetic results from Triassic sections in the Ordos Basin,North China显示文摘 | Yang Zhen-yu Ma Xing-hua Jean Besse | 1991 | Earth and Planetary Letters1991，104，： | 1 |
| 17 | Outcomes of HIV-infected patients treated for recurrent tuberculosis with the standard retreatment regimen显示文摘 | McGreevy J Jean Juste MA Severe P | 2012 | Int J Tuberc Lung Dis2012，16，6： | 1 |
| 18 | Outcomes of HIV-infected patients treated for recurrent tuberculosis with the standard retreatment regimen 显示文摘 | McGreevy J Jean Juste MA Severe P | 2012 | Int J Tuberc Lung Dis2012，16，6： | 1 |
| 19 | Interlaboratory comparison of PCR-based identification and genogrouping of Neisseria meningitides显示文摘 | Muhamed KT Jean MA Mary C | 2005 | J Clin Microbiol2005，43，1： | 1 |
| 20 | Outcomes of HIV-in- fected patients treated for recurrent tuberculosis with the standard retreatment regimen 显示文摘 | McGreevy J Jean Juste MA Severe P | 2012 | Int J Tuberc Lung Dis2012，16，6： | 1 |
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