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| 1 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 2 | Inheritance patterns of secondary symbionts during sexual reproduction of pea aphid biotypes显示文摘食草的昆虫经常怀有影响他们的生态学和进化的细菌的共生者。蚜虫招待应尽的 endosymbiont Buchnera,它为复制被要求,和其频率越过蚜虫人口变化的容许的共生者。这些似母亲播送了第二等的共生者特别地在豌豆蚜虫被学习了, Acyrthosiphon pisum,哪个港口穿上环境地依赖的效果的至少 8 不同细菌的种类(不数的 Buchnera ) 主人健康。特别地,这些共生者种类与豌豆蚜虫人口在特定的植物上喂被联系。尽管他们是继承的似母亲,这些细菌偶尔越过昆虫系被转移。如此的 nonmaternal 转移的一机制在性复制期间是到子孙的父亲的传播。迄今为止,第二等的共生者的传播在仅仅蚜虫系和 3 共生者种类的一把在蚜虫的性复制期间被调查了。更好描绘这个过程,我们通过包含属于 9 专业化主人的遗传因子型,和 117 个十字的 49 克隆的一个交叉实验在豌豆蚜虫的性复制期间调查了 7 共生者种类的继承模式。在子孙的共生者种类在从鸡蛋并且在以后的单性生殖的代孵化的 fundatrix 阶段与诊断质的 PCR 被检测。我们没发现共生者的父亲的传播的证实的案例到子孙,并且我们观察到特别共生者种(Serratia symbiotica ) 的母亲的传播是相当低效的。我们在尊重讨论这些观察到豌豆蚜虫的生态学。 | Jean Peccoud Joêl Bonhomme Frédérique Mahéo Manon de la Huerta Olivier Cosson Jean-Christophe Simon | 2014 | Insect Science2014，21，3： | 4 |
| 3 | Delving into the variations in tree species composition and richness across south american subtropical atlantic and Pampean forests显示文摘Aims We analyse here the variations in species composition and richness and the geographic ranges of the tree species occurring in south american subtropical atlantic and Pampean forests.our goals were to assess(i)the floristic consistency of usual classifications based on vegetation physiognomy,climate and elevation;(ii)the leading role of temperature-related variables on the variations in species composition and richness;(iii)the predominance of species with tropical-subtropical ranges,possibly as a result of forest expansion over grasslands after the last glacial maximum(LGM);(iv)the restriction of most subtropical endemics to stressful habitats as a possible result of past forest refuges during the LGM.Methods The region was defined by the Tropic of Capricorn to the north,the rio de la Plata to the south,the atlantic shoreline to the east and the catchment areas of the upper Paranáand uruguay rivers to the west.multivariate analyses,multiple regression modelling and variance partition analyses were performed on a database containing 63994 occurrence records of 1555 tree species in 491 forest sites and 48 environmental variables.all species were also classified according to their known geographic range.Important Findingsa main differentiation in species composition and richness was observed between the eastern windward coastlands(rain and cloud forests)and western leeward hinterlands(Araucaria and semi-decid-uous forests).Pre-defined forest types on both sides were consistent with variations in tree species composition,which were significantly related to both environmental variables and spatial proximity,with extremes of low temperature playing a chief role.Tree species rich-ness declined substantially towards the south and also from rain to seasonal forests and towards the highland summits and sandy shores.species richness was significantly correlated with both minimum temperature and actual evapotranspiration.about 91%of the subtropical flora is shared with the much richer tropical flora,prob-ably extracting species that can cope with frost outbreaks.The 145 subtropical endemics were not concentrated in harsher habitats. | Ary T.Oliveira-Filho Jean C.Budke João A.Jarenkow Pedro V.Eisenlohr Danilo R.M.Neves | 2015 | Journal of Plant Ecology2015，8，3： | 2 |
| 4 | Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database显示文摘 | Jacqueline A. Crosby MD Charles N. Catton MD Aileen Davis PhD Jean Couture MD Brian O'Sullivan MD Rita Kandel MD Carol J. Swallow MD PhD | 2001 | Annals of Surgical Oncology2001，，1： | 2 |
| 5 | Soluble CD40 ligand in prediction of acute severe pancreatitis显示文摘瞄准:在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法:在 2000 年 2 月和 2003 年 2 月之间,有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告, 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果:sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止,检测疾病的一堂严重功课的 sCD40L 的 pg/L,敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论:这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计,决定尖锐胰腺炎的严厉和预后。 | Jean Louis Frossard Philippe Morel Brenda Kwak Catherine Pastor Thierry Berney Léo Buhler Alain Von Laufen Sandrine Demulder Francois Mach | 2006 | World Journal of Gastroenterology2006，12，10： | 2 |
| 6 | 关于药学教育课程设置的现阶段和理想设置着重点的调研显示文摘 | Jean Nappi Edward H. O’Neil | 2001 | 药学教育2001，17，3： | 2 |
| 7 | Verifying remote dataintegrity inpeer-to-peer data storage:a comprehensivesurvey ofprotocols显示文摘 | NOUHA O JEAN L YVES R | 2011 | Peer-to-Peer Networking and Applications2011，5，3： | 1 |
| 8 | Photocrosslinked algi- nate hydrogels with tunable biodegradation rates and mechanical properties显示文摘 | Jean O Bouhadir KH Mansour JM | 2009 | Biomaterials2009，30，14： | 1 |
| 9 | Raman spectroscopic investigation of maghemite ferrofluids modified by the adsorption of zinc tetrasulfonated phthalocyanine显示文摘 | Jean C O Silva Marcelo H Sousa Francisco A Tourinho | 2002 | Langmuir2002，18，14： | 1 |
| 10 | Determination of chlorine dioxide in concentrated solutions in the presence of chlorine显示文摘 | Marcel Lepeintre Jeanine D Jean O 1960 | 1960 | Chim Anal1960，42，： | 1 |
| 11 | Expression mecha- nism of the hepatitis B virus (HBV) C gene and biosyn- thesis of HBe antigen显示文摘 | Jean O Levrero M Will H | 1989 | Virology1989，170，： | 1 |
| 12 | A systematic review and meta-analysis of treatments for aortic graft infection显示文摘 | Stephen O'Connor Peter Andrew Michel Batt Jean Pierre Becquemin | 2006 | Journal of Vascular Surgery2006，，1： | 1 |
| 13 | Passive Localization and Synchroni- zation Using Arbitrary Signals显示文摘 | Jean O Weiss A J | 2014 | IEEE Transactions on Signal Processing2014，62，8： | 1 |
| 14 | Pigmentary Disorders 显示文摘 | JEAN L B SETH J O | 2000 | Melanotype Biology2000，，1： | 1 |
| 15 | The relationship of prostate gland volume to extended needle biopsy on prostate cancer detection 显示文摘 | Jean O Ung Ignacio F San Francisco | 2003 | J Urol2003，169，： | 1 |
| 16 | Impact of critical social empow- erment on psychological empowerment and job satisfaction in nursing and midwifery settings显示文摘 | Maire C Jean S Teresa O' Hara | 2010 | Journal of Nursing Manage- ment2010，18，： | 1 |
| 17 | Using benefit and cost information to evaluate a food safety regulation:HACCP for meat and poultry显示文摘 | Tanya R Jean C B Michael O | 1996 | Ameriean Journal of Agricultural Economies1996，78，5： | 1 |
| 18 | Effects of culture media and inhibitors on biology of'porcine early em- bryonic development in vitro 显示文摘 | Wang H F Nelida R O Jean M F | 2009 | Livestock Science2009，，： | 1 |
| 19 | AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells显示文摘 | Jane O’Hara Damir Vareslija Jean McBryan Fiona Bane Paul Tibbitts Christopher Byrne Ronán M. Conroy Yuan Hao Peadar ó Gaora Arnold D.K. Hill Marie McIlroy Leonie S. Young | 2012 | Clinical Cancer Research2012，，12： | 1 |
| 20 | Coordinated control of wind energy conversion systems for mitigating subsynchronous interaction in DFIG- based wind farms 显示文摘 | Ulas Karaagac Sherif O Faried Jean Mahseredjian | 2014 | IEEE Transactions on Smart Grid2014，5，5： | 1 |
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