|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity 显示文摘 | Jean PA Roth RA | 1995 | Biochem Pharmacol1995，50，9： | 1 |
| 2 | Bile duet epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatoeellular injury in vitro显示文摘 | Hill DA Jean PA Roth RA | 1999 | Toxicol Sci1999，47，1： | 1 |
| 3 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 4 | Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity显示文摘 | Jean PA Roth RA | 1995 | Biochem Pharmacol1995，50，9： | 1 |
| 5 | Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro显示文摘 | Hill DA Jean PA Roth RA | 1999 | Toxicol Sci1999，47，1： | 1 |
| 6 | Exploring SEER-Medicare for changes in the treatment of laryngeal cancer among elderly medicare beneficiaries 显示文摘 | Jean RA Kallogjeri D Strope SA | 2014 | Otolaryngol Head Neck Surg2014，150，3： | 1 |
| 7 | Influence of Magnesia Surface on the Setting Time of Magnesia-phosphate Cement显示文摘 | Emmanuel Soude'e Jean Pe'ra | 2002 | Cement and Concrete Research2002，32，： | 1 |
| 8 | Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity显示文摘 | Jean PA Roth RA | 1995 | Biochem Pharmacol1995，50，9： | 1 |
| 9 | Fiber-reinforced magnesia-phosphate cement composites for rapid repair显示文摘 | Jean Péra Jean Ambroise | 1998 | Cement and Concrete Composites1998，，1： | 1 |
| 10 | Pentoxifylline attenuatesbacterial lipopolysaccharide-induced enhancement of auyl alcohol hepatotoxicity显示文摘 | Sneed RA Buchweitz JP Jean PA | 2000 | Toxicol Sci2000，56，1： | 1 |
| 11 | Pentoxifylline attenuates bacterial lipopolysaccharid-induced enhancement of allyl alcohol hepatotoxicity 显示文摘 | Sneed RA Buchweitz JP Jean PA | 2000 | Toxicol Sci2000，56，1： | 1 |
| 12 | Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity 显示文摘 | Jean PA Roth RA | 1995 | Bioehem Pharmaeol1995，50，9： | 1 |
| 13 | Improved method for high efficiency transformation of intact yeast cells 显示文摘 | Gietz D St Jean A Woods RA | 1992 | Nucleic Acids Res1992，20，6： | 1 |
| 14 | Fiber-reinforced magnesia-phosphate cement composites for rapid repair显示文摘 | Jean Péra Jean Ambroise | 1998 | Cement and Concrete Composites1998，，1： | 1 |
| 15 | Screening older adults at risk of falling with the Tinetti balance scale显示文摘 | Michel Ra?che Réjean Hébert Fran?ois Prince Hélène Corriveau | 2000 | The Lancet2000，，9234： | 1 |
| 16 | Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity显示文摘 | Jean PA Roth RA | 1995 | Biochem Pharmacol1995，50，9： | 1 |
| 17 | Pentoxifylline attenuate s bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxi city 显示文摘 | SNEED RA BUCHWEITZ JP JEAN PA | 2000 | Toxicol Sci2000，56，1： | 1 |
| 18 | Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of auyl alcohol hepatotoxicity显示文摘 | Sneed RA Buchweitz JP Jean PA | 2000 | Toxicoi Sci2000，56，1： | 1 |
| 19 | Influence of magnesia surface on the setting time of magnesia–phosphate cement显示文摘 | Emmanuel Soudée Jean Péra | 2002 | Cement and Concrete Research2002，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员