|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of CCL- 2, CCR -2 and CCR -4 in cer- ulein- induced acute pancreatitis and pancreatitis -asst:i- ated lung injm7 显示文摘 | Jean Louis Frossard Se'bastien Lenglet Fabrizio Montecuc- co | 2011 | Clin Pathol2011，64，： | 1 |
| 2 | Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implica-tion 显示文摘 | Jean C S Se J J Fadlo R K | 2000 | Cancer Rcs2000，60，1： | 1 |
| 3 | Influenee of axial thrust bearing defects on the dynamic behavior of an elastic shaft 显示文摘 | Se?bastien Berger Olivier Bonneau Jean Frene | 2000 | Tribology International2000，，33： | 1 |
| 4 | Grass competition is more important than seed ingest- ion by livestock for Acacia recruitment in South Africa 显示文摘 | Se raphine Grellier Se bastien Barot Jean - Louis Janeau | 2012 | Plant Ecology2012，，213： | 1 |
| 5 | Light-activated indole-3-acetie acid induces apoptosis in g361 human melanoma cells显示文摘 | Kim DS Kim SY Jeong YM Jean SE Kim MK Kwon SB | 2006 | Biol Pharm Bull2006，29，12： | 1 |
| 6 | Influence of axial thrust bearing defects on the dynamic behavior of an elastic shaft 显示文摘 | Se'bastien Berger Olivier Bonneau Jean Frene | 2000 | Tribology International2000，33，2000： | 1 |
| 7 | Outcomes amongelderly bariatric patients at a high- volume center 显示文摘 | Dunkle-Blatter SE St Jean MR Whitehead C | 2007 | Surg Obes Relat Dis2007，3，2： | 1 |
| 8 | Fate of patients undergoing translunminal angioplasty for lower-limb ischemia显示文摘 | Jeans WD Armstrongnd S Cole SE | 1990 | Radiology1990，177，： | 1 |
| 9 | Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation显示文摘 | Janghee Woo Juna Lee Young Kwang Chae Myoung Sook Kim Jin Hyen Baek Jong Chul Park Min Joo Park Ian M. Smith Barry Trink Edward Ratovitski Taekyul Lee Bumsoo Park Se Jin Jang Jean C. Soria Joseph A. Califano David Sidransky Chulso Moon | 2008 | Cancer Letters2008，，1： | 1 |
| 10 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 11 | Consultation meeting on tuberculosis and diabetes mellitus : meeting summary and recommendation 显示文摘 | Ottmani SE Murray MB Jean CY | 2010 | Int J Tuberc Lung Dis2010，14，12： | 1 |
| 12 | Overex- pression of cyclin B1 in early - stage non - small cell lung cancer and its clillical implication 显示文摘 | Sofia Jean - Charles Jin Jang Se Fadlo R | 2000 | Cancer Res2000，60，： | 1 |
| 13 | Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells显示文摘 | Kim DS Jean SE Park KC | 2004 | Cell Signal2004，16，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员