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| 1 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | RePerfusion injury the focal cerebral ischemia:The role of inflammation and the theraputic zon 显示文摘 | Jean W C | 1998 | Neurosurgery1998，43，： | 1 |
| 4 | Titration of ieoflurane using BIS index improves early recovery of elderly patients un-dergoing orthopedicsurgeries显示文摘 | Jean W Dajun S Hannah BL el al | 2002 | Can J Anaesth2002，49，11： | 1 |
| 5 | NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins显示文摘 | Andreas W Jean MF Hanns M | 1997 | J Neurochem1997，68，： | 1 |
| 6 | How should adenoid enlargement be measured?A radiological study based on the inter-observer agreement显示文摘 | Jeans W D Fernado D C J Maw A R | 1981 | Clin Radiol1981，，32： | 1 |
| 7 | Application of human umbilical cord blood -derived mesenchymal stem cells in dis- ease models显示文摘 | Kim JY HB Jean YS Yang W Oh and JW Chang | 2011 | World J Stem Cells2011，2，： | 1 |
| 8 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 9 | Doctoral education in social work :what we know and what we need to know显示文摘 | Jeane W A Alexis N K | 2009 | Social Work2009，54，1： | 1 |
| 10 | System parameters of soil foundation for time domain dynamic analysis显示文摘 | | 1990 | Earthquake Engineering and Structure Dynamic1990，19，3： | 1 |
| 11 | Spinal Metastases:indications for and resuits of percutaneous injection of acrylic surgical cement显示文摘 | Alain W M Jacques C Jean M S | 1996 | Radiology1996，199，3： | 1 |
| 12 | Litter composition rather than plant presence affects decomposition of tropical litter mixtures 显示文摘 | Sylvain C Jean W Olaf B | 2011 | Plant Soil2011，343，12： | 1 |
| 13 | Parents of children in the pediatric inten- sive care unit:what are their needs显示文摘 | Jean W Adeline M | 1988 | Heart & Lung1988，17，5： | 1 |
| 14 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 15 | Epithelial to mesenchymal transition and breast cancer显示文摘 | EVA T C ERIK W T JEAN P T | 2009 | Breast Cancer Research2009，11，6： | 1 |
| 16 | Reperfusion injry after focal cerebral ischemia:the role of inflammation and the therapeutic horizon显示文摘 | JEAN W C SPELLMAN S R NUSSBAUM E S | 1998 | Neurosurgery1998，43，： | 1 |
| 17 | Mechanism of tetracycline sorption on rectorite 显示文摘 | Chang P H Jean J S Jiang W T | 2009 | Colloid Surface A2009，339，13： | 1 |
| 18 | Efficient finite element techniques for limit analysis of suction caissons under lateral loads显示文摘 | SUKUMARAN B MCCARRON W O JEAN JEAN P Abouseeda H | 1999 | Computers and Geotechnics1999，24，2： | 1 |
| 19 | Surface roughness measurements of low-scatter mirror sand roughness standards 显示文摘 | Karl H G Peter G W Jean M B | 1984 | Applied Optics1984，23，21： | 1 |
| 20 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
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