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| 1 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 2 | Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway显示文摘 | Jeffrey L. Apfelbaum Carin A. Hagberg Robert A. Caplan Casey D. Blitt Richard T. Connis David G. Nickinovich Carin A. Hagberg Robert A. Caplan Jonathan L. Benumof Frederic A. Berry Casey D. Blitt Robert H. Bode Frederick W. Cheney Richard T. Connis Orin F | 2013 | Anesthesiology2013，，2： | 4 |
| 3 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction显示文摘 | Jeffrey L Anderson John F Carlquist Joseph B Muhlestein Benjamin D Horne Sidney P Elmer | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 6 | Future technology-enabled care for diabetes and hyperglycemia in the hospital setting显示文摘Patients with diabetes are increasingly common in hospital settings where optimal glycemic control remains challenging.Inpatient technology-enabled support systems are being designed,adapted and evaluated to meet this challenge.Insulin pump use,increasingly common in outpatients,has been shown to be safe among select inpatients.Dedicated pump protocols and provider training are needed to optimize pump use in the hospital.Continuous glucose monitoring(CGM)has been shown to be comparable to usual care for blood glucose surveillance in intensive care unit(ICU)settings but data on cost effectiveness is lacking.CGM use in non-ICU settings remains investigational and patient use of home CGM in inpatient settings is not recommended due to safety concerns.Compared to unstructured insulin prescription,a continuum of effective electronic medical record-based support for insulin prescription exists from passive order sets to clinical decision support to fully automated electronic Glycemic Management Systems.Relative efficacy and cost among these systems remains unanswered.An array of novel platforms are being evaluated to engage patients in technology-enabled diabetes education in the hospital.These hold tremendous promise in affording universal access to hospitalized patients with diabetes to effective self-management education and its attendant short/long term clinical benefits. | Alex Renato Montero Jeffrey S Dubin Paul Sack Michelle F Magee | 2019 | World Journal of Diabetes2019，10，9： | 2 |
| 7 | Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice显示文摘 | Marrotte Eric J Chen Dan-Dan Hakim Jeffrey S Chen Alex F | 2010 | Journal of Clinical Investigation2010，，12： | 2 |
| 8 | Nonparametric fix-interval smoothing with vector splines 显示文摘 | Jeffrey A F | 1991 | IEEE Tranction on signal proces sing1991，39，4： | 2 |
| 9 | Harvard Business ReviewExploiting the Virtual Value Chain显示文摘 | | 1995 | Harvard Business School Press1995，，： | 1 |
| 10 | A new method for the nonlinear transformation of means and covariances in filters and estimators 显示文摘 | SIMON JULIER JEFFREY UHLMANN HUGH F DURRANT-WHYTE | 2000 | IEEE Transactions on Automatic Control2000，45，3： | 1 |
| 11 | Positive identification of an immigrtion test-case using human DNA fingerprints显示文摘 | Jeffreys A J Brookfield J F Y Semeonoff R | 1985 | Nature1985，317，： | 1 |
| 12 | Remote sensing and geomorphometry for studying relief production in high mountains显示文摘 | Michael P Bishop John F Shroder Jr Jeffrey D Colby | 2003 | Geomorphology2003，55，： | 1 |
| 13 | Leptin and the regulation of body weight in mammals显示文摘 | Jeffrey M F Jeffrey L H | 1998 | Nature1998，395，： | 1 |
| 14 | Facial asymmetry quantification for expression-invariant human identification 显示文摘 | Liu Yanxi Schmidt Karen L Cohn Jeffrey F | 2003 | Computer Vision and Image Understanding2003，91，12： | 1 |
| 15 | Lipid metabolism during endurance exercise显示文摘 | Jeffrey F Horowitz and Samuel Klein | 2000 | American Journal of Clinical Nutrition2000，72，2： | 1 |
| 16 | Nonirtherited risk factors and congenital cardiovascular defects 显示文摘 | Kathy J J Adolfo C Jeffrey A F | 2007 | Circulation2007，115，： | 1 |
| 17 | Modeling respiration rate of fresh fruits and vegetable for modified atmosphere packages: a review显示文摘 | Susana C F Fernanda A R Jeffrey K B | 2002 | Journal of Food Engineering2002，52，6： | 1 |
| 18 | Combination of bacterial vaginosis and leukorrhea as a predictor of cervical chlamydial or gonococcal infection 显示文摘 | Lauren S Jeffrey F P Walter H | 2002 | Obstet Gynecol2002，99，4： | 1 |
| 19 | New spectrophotometric equations for determining chlorophylls a, b, cl and c2 in higher plants, algae and natural phytoplankton显示文摘 | JEFFREY S W HUMPHREY G F | 1975 | Bilchem Physiol Pflanz1975，167，： | 1 |
| 20 | Pelvic inflammatory dis- ease in adolescents显示文摘 | Gray-Swain Rosanna M Jeffrey F | 2006 | Current Opinion in Obstetrics & Gynecol- ogy2006，，18： | 1 |
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