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| 1 | Surgery for metastatic pancreatic neuroendocrine tumors: a narrative review显示文摘Background and Objective:Pancreatic neuroendocrine tumors(PanNETs)are derived from the islet cells of the pancreas and have been increasing in incidence.Most of these tumors are nonfunctional although some can secrete hormones and lead to hormone-specific clinical syndromes.Surgery is the mainstay of treatment for localized tumors,however,surgical resection is controversial in metastatic PanNETs.This narrative review seeks to summarize the current literature surrounding surgery,specifically in the controversial area of metastatic PanNETs,review current treatment paradigms,and understand the benefits of surgery in this group of patients.Methods:Authors searched PubMed using the terms“surgery pancreatic neuroendocrine tumor”,“metastatic neuroendocrine tumor”,and“liver debulking neuroendocrine tumor”from January 1990 to June 2022.Only English language publications were considered.Key Content and Findings:There is no consensus among the leading specialty organizations regarding surgery for metastatic PanNETs.When considering surgery for metastatic PanNETs,tumor grade and morphology,location of the primary tumor,extra-hepatic or extra-abdominal disease,as well as liver tumor burden and metastatic distribution should be considered.Because the liver is the most common site of metastasis and liver failure is the most common cause of death in patients with hepatic metastases,attention is centered here on debulking and other ablative techniques.Liver transplantation is rarely used for hepatic metastases but could be beneficial in a small subset of patients.Retrospective studies have demonstrated improvement in survival and symptoms after surgery for metastatic disease,but the lack of prospective randomized control trials significantly limits analysis of surgical benefits in patients with metastatic PanNETs.Conclusions:Surgery is the standard of care for localized PanNETs,while it remains controversial in metastatic disease.Many studies have shown a survival and symptomatic benefit to surgery and liver debulking in select groups of patients.However,most of the studies on which recommendations are based in this population are retrospective in nature and are subject to selection bias.This presents an opportunity for future investigation. | Jelani K.Williams Jason L.Schwarz Xavier M.Keutgen | 2023 | Hepatobiliary Surgery and Nutrition2023，12，1： | 2 |
| 2 | Aging-related early changes in markers of ventricular and matrix remodeling after reper- fused ST-segment elevation myocardial infarction in the canine mod- el: effect of early therapy with an angiotensin II type 1 receptor blocker显示文摘 | Jugdutt BI Jelani A Palaniyappan A | 2010 | Circulation2010，122，4： | 1 |
| 3 | STEMI and heart failure in the el- derly: role of adverse remodeling显示文摘 | JELANI A JUGDUIT BI | 2010 | Heart Fail Rev2010，15，5： | 1 |
| 4 | Treatment of anemia in heart failure : Potential risks and benefits of intravenous iron therapy in cardi nlar disease 显示文摘 | JELANI Q U KATZ S D | 2010 | Cardiol Rev2010，18，5： | 1 |
| 5 | Biocompatibility and Osteogenic Potential of New Generation Endodontic Materials Established by Using Primary Osteoblasts显示文摘 | Jelani T. Washington Emet Schneiderman Robert Spears Claudia R. Fernandez Jianing He Lynne A. Opperman | 2011 | Journal of Endodontics2011，，8： | 1 |
| 6 | Zebrafish cypher is important for somite formation and heart development 显示文摘 | David LM Ines JM Jelani TD | 2006 | Dev Biol2006，299，8： | 1 |
| 7 | Perceived Support and Internalizing Symptoms in African American Adolescents: Self-Esteem and Ethnic Identity as Mediators显示文摘 | Noni K. Gaylord-Harden Brian L. Ragsdale Jelani Mandara Maryse H. Richards Anne C. Petersen | 2007 | Journal of Youth and Adolescence2007，，1： | 1 |
| 8 | Zebrafish cypher is important for somite formation and heart development显示文摘 | David LM Ines J Jelani T | 2006 | Developmental Biology2006，299，8： | 1 |
| 9 | Treatment of anemia in heart failure:potential risks and benefits of intravenous iron therapy in cardiovascular disease显示文摘 | Jelani QU Katz SD | 2010 | Cardiol Rev2010，18，5： | 1 |
| 10 | Treatment with iron of patients with heart failure with and without anemia显示文摘 | Jelani QU Attanasio P Katz SD et ai | 2010 | Heart Fail Clin2010，6，： | 1 |
| 11 | Treatment of anemia in heart failure:Potential risks and benefits of intravenous iron therapy in cardiovascular disease显示文摘 | Jelani QU Katz SD | | 0，，05： | 1 |
| 12 | STEMI and heart failure in the elderly: role of adverse remodeling显示文摘 | Anwar Jelani Bodh I. Jugdutt | 2010 | Heart Failure Reviews2010，，： | 1 |
| 13 | Treatment of anemia in heart failure: potential risks and benefits of intravenous iron therapy in cardiovascular disease 显示文摘 | Jelani QU Katz SD | 2010 | Cardiol Rev2010，18，5： | 1 |
| 14 | Zebrafish cypher is important for somite formation and heart development显示文摘 | David L.M. van der Meer Ines J. Marques Jelani T.D. Leito Jaya Besser Jeroen Bakkers Edwige Schoonheere Christoph P. Bagowski | 2006 | Developmental Biology2006，，2： | 1 |
| 15 | 哈里·斯泰尔:单飞?等着我们的新专辑吧显示文摘自从泽恩·马利克宣布了退出单向乐队这个“五雷轰顶”的消息后,粉丝们就一直担心尼尔、路易斯、利亚姆或者哈里当中有人会步他后尘。所以当哈里·斯泰尔准备单飞的传言传开以后,1D粉丝们就进入了全面惊恐的状态。自从“再次启程”巡回演唱会暂停后,哈里就一直很消沉,让很多人相信他甩开了自己的兄弟,把自己关在录音室里录好音乐去了。 | Jelani Addams Rosa 俞力 | 2015 | 疯狂英语(初中天地)2015，0，8： | 0 |
| 16 | Thermomechanical response of aluminum alloys under the combined action of tensile loading and laser irradiations显示文摘This study reports the investigation of the thermomechanical behavior of aluminum alloys(Al-1060, Al-6061, and Al-7075) under the combined action of tensile loading and laser irradiations. The continuous wave ytterbium fiber laser(wavelength 1080 nm) was employed as the irradiation source, while tensile loading was provided by the tensile testing machine. The effects of various pre-loading and laser power densities on the failure time, temperature distribution, and the deformation behavior of aluminum alloys are analyzed. The experimental results represent the significant reduction in failure time for higher laser power densities and for high preloading values, which implies that preloading may contribute a significant role in the failure of the material at elevated temperature. Fracture on a microscopic scale was predominantly ductile comprising micro-void nucleation, growth, and coalescence. The Al-1060 specimens behaved plastically to some extent, while Al-6061 and Al-7075 specimens experienced catastrophic failure. The reason and characterization of material failure by tensile and laser loading are explored in detail. A comparative behavior of under-tested materials is also investigated. This work suggests that studies considering only combined loading are not enough to fully understand the mechanical behavior of under-tested materials. For complete characterization, one should consider the effect of heating as well as loading rate and the corresponding involved processes with the help of thermomechanical coupling and the thermal elastic-plastic theory. | Mohsan Jelani 李泽文 沈中华 Maryam Sardar | 2018 | Chinese Physics B2018，27，3： | 0 |
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