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| 1 | Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems显示文摘Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ways.Consumption,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth System.Changes in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious consequences.However,current models do not incorporate these critical feedbacks.We argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real systems.In particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population projections.his makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current models.he importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations. | Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.Yakovenko Ning Zeng | 2016 | National Science Review2016，3，4： | 34 |
| 2 | A complete compilation of matrix metalloproteinase expression in human malignant gliomas显示文摘Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy. | Carsten Hagemann Jelena Anacker Ralf-Ingo Ernestus Giles H Vince | 2012 | World Journal of Clinical Oncology2012，3，5： | 18 |
| 3 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 4 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 5 | 波激振动的理论预报及与实船试验结果的比较(英文)显示文摘本文研究一艘大型海船的波激振动问题。该船在运行过程中发生了频繁的波激振动,导致严重的结构裂纹。文中对四种预报船体波激振动响应的理论及其计算机程序进行了描述。这些理论在计算水动力载荷和结构振动时具有各自的特点,如:线性、二阶、非线性、频域、时域、二维和三维等。相应的程序(WASIM,SOST,SINO和VERES)对低频波浪诱导响应预报已有较多的验证。文中对各程序在波激振动预报中的前提条件作了说明。计算中进行了参数敏感性分析并给出了主要结果。在与实船试验结果的比较过程中选择了十个不同的工况,对其海况、航向和试验现象给出了简要描述。对低频波浪诱导和高频波激振动响应分别进行了比较,得出了一些有意义的结论。 | 顾学康 GauteStorhaug Jelena Vidic-Perunovic Gabriel Holtsmark Jens Block Helmers | 2003 | 船舶力学2003，7，6： | 5 |
| 6 | Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer显示文摘 | Ilya Gukovsky Ning Li Jelena Todoric Anna Gukovskaya Michael Karin | 2013 | Gastroenterology2013，，6： | 5 |
| 7 | Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture显示文摘Pyridine 核苷酸, ascorbate 和谷胱甘肽是在植物房间的主要氧化还原作用代谢物,与在细胞的氧化还原作用动态平衡和房间周期的规定的特定的角色。然而,代谢物在指数的生长期间分享的这些的规定和他们在细胞周期的精确功能尚待被描绘。在在文化的 Arabidopsis 房间的指数的生长期间的许多 ascorbate,谷胱甘肽,和 pyridine 核苷酸的现在的分析为每这些氧化还原作用水池的微分规定提供证据。Ascorbate 早很充满生长周期,但是谷胱甘肽在这个点是低的。到 dehydroascorbate 的细胞的 ascorbate 和到谷胱甘肽二硫化物比率的减少的谷胱甘肽(GSH ) 高、不变,但是 pyridine 核苷酸分享大部分在指数的生长的时期上被氧化并且一旦生长停止了,仅仅变得更多减少。谷胱甘肽水池增加了与同时 poly (自动数据处理核糖) 聚合酶(PARP ) 活动并且一次由 transcriptome 信息是的高房间周期活动随许多 PARP1 和 PARP2 mRNAs 的增加显示了。在在细胞质和原子核之间的 GSH 的细胞内部的划分的显著变化被观察。由冲淡的指数的生长阶段的扩展或改变导致的媒介在谷胱甘肽和菸碱腺嘌 dinucleotide 增加,氧化形式( NAD ) -plus-nicotinamide 腺嘌 dinucleotide ,减少的形式( NADH )水池并且到更高的 NAD/NADH 比率但是菸碱腺嘌 dinucleotide 磷酸盐,氧化形式( NADP ) -plus-nicotinamide 腺嘌 dinucleotide 磷酸盐,减少的形式( NADPH )水池尺寸,和 NAPD/NADPH 比率是影响的少得多。在指数的生长阶段结束了以前, ascorbate,谷胱甘肽,和 pyridine 核苷酸水池和 PARP 活动减少了。我们断定在生长周期期间处于细胞内部的氧化还原作用状态有显著变化,但是氧化还原作用动态平衡被主要氧化还原作用 pyridine 核苷酸,谷胱甘肽,和 ascorbate 水池的相互影响维持。在 PARP 表示和活动和 GSH 累积并且发现那 GSH 能被招募到原子核之间的关联建议在氧化还原作用规定和原子酶活动之间的一种关系。 | Till K. Pellny Vittoria Locato Pedro Diaz Vivancos Jelena Markovic Laura De Gara Federico V. Pallardo Christine H. Foyer | 2009 | Molecular Plant2009，2，3： | 4 |
| 8 | Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease显示文摘The role of fecal microbial transplant(FMT) in the treatment of pediatric gastrointestinal disease has become increasingly popular among pediatric practitioners, patients, and parents. The success of FMT for the treatment of recurrent Clostridium difficile infection(RCDI) has bolstered interest in its potential application to other disease states, such as inflammatory bowel disease(IBD). FMT has particular interest in pediatrics, given the concerns of patients and parents about rates of adverse events with existing therapeutic options, and the greater cumulative medication burden associated with childhoodonset disease. Published literature on the use of FMT in pediatrics is sparse. Only 45 pediatric patients treated for RCDI have been reported, and only 27 pediatric patients with pediatric IBD. The pediatric microbiome may uniquely respond to microbial-based therapies. This review will provide a comprehensive overview of fecal microbial transplant and its potential role in the treatment of pediatric inflammatory bowel disease. We will discuss the microbiome in pediatric inflammatory bowel disease, existing adult and pediatric literature on the use of FMT in IBD treatment, and pediatric FMT trials that are currently recruiting patients. This review will also discuss features of the microbiome that may be associated with host response in fecal transplant, and potential challenges and opportunities for the future of FMT in pediatric IBD treatment. | Alice Yuxin Wang Jelena Popov Nikhil Pai | 2016 | World Journal of Gastroenterology2016，22，47： | 4 |
| 9 | Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats显示文摘Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal. | KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC MILOSEVIC Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 10 | Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite显示文摘 | Nenad Ignjatovic Zorica Aj dukovic Jelena Rajkovic Stevo Najman Dragan Mihailovic Dragan Uskokovic | 2015 | Journal of Bionic Engineering2015，12，4： | 3 |
| 11 | Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients显示文摘AIM: To study whether alterations in the glycosylation of immunoglobulin G (IgG) specific to the ThomsenFriedenreich glycotope (TF) have diagnostic and prognostic potential in gastric cancer. METHODS: Serum samples were obtained from patients with histologically verified gastric carcinoma (n = 89), healthy blood donors (n = 40), and patients with benign stomach diseases (n = 22). The lectin-enzymelinked immunosorbent assay-based glycoprofiling of TF-specific IgG (anti-TF IgG) was performed using synthetic TF-polyacrylamide conjugate as antigen, total IgG purified by affinity chromatography on protein G sepharose, and lectins of various sugar specificities: mannose-specific concanavalin A (ConA), fucose-specificAleuria aurantia lectin (AAL) and sialic acid-specific Sambucus nigra agglutinin (SNA). The sensitivity and specificity of the differences between cancer patients and controls were evaluated by receiver operator characteristic (ROC) curve analysis. Overall survival was analyzed by the Kaplan-Meier method. Time-dependent ROC curve statistics were applied to determine cut-off values for survival analysis. All calculations and comparisons were performed using the GraphPad Prism 5 and SPSS 15.0 software.RESULTS: The level of TF-specific IgG was significantly increased in cancer patients compared with non-cancer controls (P < 0.001). This increase was pronounced mostly in stage 1 of the disease. Cancer patients showed a higher level of ConA binding to antiTF-IgG (P < 0.05) and a very low level of SNA lectin binding (P = 0.0001). No appreciable stage-dependency of the binding of any lectin to anti-TF IgG was found. A strong positive correlation between the binding of AAL and SNA was found in all groups studied (r = 0.71-0.72; P < 0.0001). The changes in ConA reactivity were not related to those of the fucoseor sialic acid-specific lectin. Changes in the SNA binding index and the ConA/SNA binding ratio demonstrated good sensitivity and specificity for stomach cancer: sensitivity 78.79% (95%CI: 61.09-91.02) and 72.73% (95%CI: 57.21-85.04); specificity 79.17 (95%CI: 65.01-89.53) and 88.64% (95%CI: 71.8-96.6), for the SNA binding index and the ConA/SNA binding ratio, respectively. The other combinations of lectins did not improve the accuracy of the assay. The low level of ConA-positive anti-TF IgG was associated with a survival benefit in cancer patients (HR = 1.56; 95%CI: 0.78-3.09; P = 0.19), especially in stages 3-4 of the disease (HR = 2.17; 95%CI: 0.98-4.79; P = 0.048). A significantly better survival rate was found in all cancer patients with a low reactivity of anti-TF IgG to the fucose-specific AAL lectin (HR = 2.39; 95%CI: 1.0-5.7;P = 0.038).CONCLUSION: The changes in the TF-specific IgG glycosylation pattern can be used as a biomarker for stomach cancer detection, and to predict patient survival. | Kristel Kodar Jelena Izotova Kersti Klaamas Boris Sergeyev Lilian Jrvekülg Oleg Kurtenkov | 2013 | World Journal of Gastroenterology2013，19，23： | 3 |
| 12 | Correlation between Ozone and Total VOCs in Printing Environment显示文摘 | Kiurski Jelena Adamovie Dragan Oros Ivana Krstie Jelena Adamovie Savka Vojinovie Miloradov Mirjana Kovacevic Ilija | 2011 | Journal of Chemistry and Chemical Engineering2011，5，5： | 3 |
| 13 | Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells显示文摘BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed recently.Bearing in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering constructs.AIM To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and OBs.METHODS ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral matrix.At 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 wk.RESULTS The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after implantation.BC had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and BPEO.Endothelial-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and BPEO.BPEO had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined constructs.Except Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in vivo incubation that induced late onset of Spp1 expression and pronounced osteocalcin immunoexpression at 2 and 8 wk.Tissue regression was noticed in BPEO constructs after 8 wk.CONCLUSION Ectopically implanted BPEO constructs had a favorable impact on vascularization and osteogenesis,but tissue regression imposed the need for discovering a more optimal EC/OB ratio prior to considerations for clinical applications. | Jelena G Najdanović Vladimir J Cvetković Sanja T Stojanović MarijaĐVukelić-Nikolić Jelena MŽivković Stevo J Najman | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 14 | Exploring new treatment options for polycystic ovary syndrome: Review of a novel antidiabetic agent SGLT2 inhibitor显示文摘Polycystic ovary syndrome(PCOS)is the most common endocrinopathy in women of reproductive age associated with long-term metabolic and cardiovascular consequences.A plethora of symptoms and their severity differentiate on an individual level,giving the syndrome numerous phenotypes.Due to menstrual cycle abnormalities,women suffer from irregular menstrual bleeding,difficulty in conception,and infertility.Furthermore,the risk of pregnancy complications such as gestational diabetes mellitus,hypertensive disorders of pregnancy,and preterm birth are higher in women with PCOS than in the general population.Often,women with PCOS have comorbidities such as dyslipidemia,obesity,glucose intolerance or diabetes type 2,non-alcoholic fatty liver disease,and metabolic syndrome,which all influence the treatment plan.Historic insulinsensitizing agents,although good for some of the metabolic derangements,do not offer long-term cardiovascular benefits;therefore,new treatment options are of paramount importance.Sodium-glucose co-transporter-2(SGLT-2)inhibitors,a new class of antidiabetic agents with beneficial cardiovascular,bodyweight,and antihyperglycemic effects,although not approved for the treatment of PCOS,might be an attractive therapeutic addition in the PCOS armamentarium.Namely,recent studies with SGLT-2 inhibitors showed promising improvements in anthropometric parameters and body composition in patients with PCOS.It is important to further explore the SGLT-2 inhibitors potential as an early therapeutic option because of the PCOS-related risk of metabolic,reproductive,and psychological consequences. | Jelena Marinkovic-Radosevic Maja Cigrovski Berkovic Egon Kruezi Ines Bilic-Curcic Anna Mrzljak | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 15 | Co-expression of the proteinase inhibitors oryzacystatin I and oryzacystatin II in transgenic potato alters Colorado potato beetle larval development显示文摘科罗拉多土豆甲壳虫(CPB;Leptinotarsa decemlineata 说,翘目:Chrysomelidae ) 显示出显著适应性到许多控制措施。尽管 oryzacystatin 我和 II (OCI 和 OCII ) 在控制为食物消化使用半胱氨酸朊酶的害虫有潜力,在土豆的单个 OC 基因的表示展出了一最小或 CPB 健康特点上的没有效果。这研究的目的是在土豆(茄属 tuberosum L.) 检验 coexpressed OCI 和 OCII 的效果 CPB 幼虫上的栽培变种 Desiree, Dragaevka 和 Jelica。CPB 幼虫的朊酶的生长参数,消费率和食物利用,以及活动是 assayed。第二和第三个中间形态幼虫在更高相对的生长和消费比在 nontransformed 叶子喂的幼虫评估的更早、有的转变叶子 molted 上喂了,当食物利用的效率是未受影响的时。相反,消费的叶子的第四中间形态最大值重量获得和数量是大约 20% 为在转基因的土豆上喂的幼虫更低。第三个中间形态幼虫的全部的朊酶活动的分析在 azocasein 水解作用测量的全面解朊的活动揭示了减小,在土豆的摄取离开以后,与半胱氨酸朊酶活动 24 h 的抑制伴随了表示 OCI 和 OCII。然而,在在转变叶子的长期的喂以后,幼虫的解朊的活动变得类似于控制。尽管在 OCI/OCII 叶子喂没影响幼虫的幸存, OC 基因的 coexpression 减少了发展时间并且显著地因此减少了 CPB 幼虫引起的植物损坏。 | Aleksandar Cingel Jelena Savic Jelica Lazarevic Tatjana Cosic Martin Raspor Ann Smigocki Slavica Ninkovic | 2017 | Insect Science2017，24，5： | 3 |
| 16 | Topographic and lithologic controls behind mountain depopulation in Zlatibor District(Western Serbia)显示文摘Mountain depopulation is a worldwide phenomenon observed in all continents. It has varied socio-economic reasons;among others, the low profitability of traditional agriculture, the better job possibilities and the higher level of services in urban settlements. However, it is often recognized that depopulation is related to natural factors such as elevation, slope or lithology. It is also observed that protected areas are frequently established in depopulated mountain regions. Their primary aim is the conservation of nature, but they may help tourism development as well. Tourism, in turn, may slow down or even reverse the process of depopulation. In this study, we investigate the impact of topographic and lithologic factors, namely of karst settings, on mountain demographic processes and the relationship of protected areas and tourism through the example of the northern part of Zlatibor District(Western Serbia). The study area is characterized by mountains and hills at elevations from 200 to 1600 m a.s.l. Our aim is to find GIS-based statistical relationships between topographic, lithologic factors and demographic characteristics. In this area, mountain depopulation started after WWII, and weproved that this process was strongly controlled by topographic factors. The higher and more dissected the area, the more significant is the decrease of the population and the more advanced is the ageing. As a result, population density contrasts are much more pronounced now than 70 years ago. After WWII, depopulation and ageing became gradually more serious on karstic terrains than on non-karst. However, by using compound topographic and lithologic types, we proved that it is not the effect of karst, but the effect of topography. The flow of population from hills and mountains to valleys and basins are closely related to the restructuring of the economic sectors. At present, for the study area, the development of tourism is unequivocally naturebased and connected to protected areas, namely to Tara National Park, Zlatibor Nature Park and ?argan–Mokra Gora Nature Park. In this paper, we also demonstrate how lithology influences tourism possibilities. The leading role of Zlatibor in tourism development is largely thanks to its favourable position on a main transit route. | TELBISZ Tamas BRANKOV Jovana CALIC Jelena | 2020 | Journal of Mountain Science2020，17，2： | 3 |
| 17 | Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals显示文摘发炎是对试图消除侮辱的微生物引起的感染或无菌的损害的主人反应,修理织物并且恢复动态平衡。巨噬细胞和 NLRP3 inflammasome 是为侮辱的两种类型的关键哨兵。尽管 NLRP3 inflammasome 被在无菌的损害期间释放的微生物引起的产品和分子激活,这很好被建立,信号的这些不同类型得到的回答是否是不同的,是不清楚的。在这研究,我们把 lipopolysaccharide 和肿瘤坏死因素用作原型的微生物引起、无菌的信号 1 刺激,分别地告知 NLRP3 inflammasome。我们然后使用了细菌的毒素 nigericin 和免除坏死的房间的一个普通产品, ATP 原型的微生物引起、无菌的信号 2 刺激,分别地在鼠标和人的巨噬细胞触发 NLRP3 inflammasome 建筑群的汇编。当信号 1 和信号 2 是无菌的时,我们发现 NLRP3 inflammasome 回答最弱,但是当二个信号中的至少一个是微生物引起的时,回答更快、更强壮。最终,最快速并且当两个信号是微生物引起的时,有势力回答被得到。一起,这些数据建议微生物引起对无菌的信号是不同的,运动地并且在大小,处于他们产生 inflammasome 依赖的回答的能力。对无菌对微生物引起的刺激的 NLRP3 回答的这个层次多半反映迫切需要让免疫系统对感染的存在很快作出回应停止病原体传播。 | Jelena S Bezbradica Rebecca C Coll Kate Schroder | 2017 | Cellular & Molecular Immunology2017，14，1： | 3 |
| 18 | Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics显示文摘Objective: Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of resistance to previously effective treatments presents a serious challenge and new approaches for melanoma treatment are urgently needed. The objective of this study was to examine the effects of telmisartan, an AGTR1 inhibitor and a partial agonist of PPARγ, on melanoma cells as a potential agent for repurposing in melanoma treatment.Methods: Expression of AGTR1 and PPARγ m RNA in melanoma patient tumor samples was examined in publicly available datasets and confirmed in melanoma cell lines by qRT-PCR. A panel of melanoma cell lines was tested in viability, apoptosis and metabolic assays in presence of telmisartan by flow cytometry and immunocytochemistry. A cytotoxic effect of combinations of telmisartan and targeted therapy vemurafenib was examined using the Chou-Talalay combination index method.Results: Both AGTR1 and PPARγ mRNA were expressed in melanoma patient tumor samples and decreased compared to the expression in the healthy skin. In vitro, we found that telmisartan decreased melanoma cell viability by inducing cell apoptosis.Increased glucose uptake, but not utilization, in the presence of telmisartan caused the fission of mitochondria and release of reactive oxygen species. Telmisartan altered the cell bioenergetics, thereby synergizing with vemurafenib in vitro, and even sensitized vemurafenib-resistant cells to the treatment.Conclusions: Given that the effective doses of telmisartan examined in our study can be administered to patients and that telmisartan is a widely used and safe antihypertensive drug, our findings provide the scientific rationale for testing its efficacy in treatment of melanoma progression. | Jelena Grahovac Tatjana Srdic-Rajic Juan Francisco Santibanez Marijana Pavlovic Milena Cavic Sinisa Radulovic1 | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 19 | Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy:A case report and review of literature显示文摘BACKGROUND Leiomyosarcoma(LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature(limited to English).CASE SUMMARY Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed,followed by radiotherapy. Since metastases were also discovered in the lungs,sternum, and femur, chemotherapy was administered as well.Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus.CONCLUSION Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors. | Snezana Vujosevic Djordjije Krnjevic Milan Bogojevic Ljiljana Vuckovic Aleksandar Filipovic Du?ko Dun?erovi? Jelena Sopta | 2019 | World Journal of Clinical Cases2019，7，4： | 3 |
| 20 | Development of CO2 Selective Poly(Ethylene Oxide)-Based Membranes: From Laboratory to Pilot Plant Scale显示文摘气体膜分离法是从气流中分离二氧化碳(CO_2)的最有前途的技术之一。例如,采用该技术对燃烧过程中的烟气进行处理,以达到CO_2捕集和封存的目的。聚环氧乙烷嵌段共聚物能够很好地应用于膜分离技术,如Pebax~?或Poly Active^(TM)。本文采用Poly Active^(TM)作为复合薄膜的选择层。在环境温度下,当CO_2/N_2选择性超过55时,这种薄膜的CO_2渗透率高达4 m^3(STP)·m^(–2)·h^(–1)·bar^(–1)(注:1 bar=105 Pa)。这种薄膜可以按照中试规模进行生产放大,而且可以设计成不同的平面膜组件。采用单一气体渗透数据作为唯一的实验输入而开发出的仿真工具可以准确预测这种膜组件的性能。在不同的中试研究中,我们利用烟气和沼气作为原料气流,反复检测这些膜和膜组件的性能。Poly Active^(TM)在检测中显示出了稳定的分离性能,表明Poly Active^(TM)非常适用于作为膜材料进行工业规模气体处理。 | Torsten Brinkmann Jelena Lilleparg Heiko Notzke Jan Pohlmann Sergey Shishatskiy Jan Wind Thorsten Wolff | 2017 | Engineering2017，3，4： | 3 |
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