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| 1 | Development tendencies of moulding and core sands显示文摘Further development of the technology for making moulding and core sands will be strictly limited by tough requirements due to protection of the natural environment. These tendencies are becoming more and more tense, so that we will reach a point when even processes, that from technological point of view fulfill high requirements of the foundry industry, must be replaced by more ecologically-friendly solutions. Hence, technologies using synthetic resins as binding materials will be limited. This paper presents some predictable development tendencies of moulding and core sands. The increasing role of inorganic substances will be noticed, including silicate binders with significantly improved properties, such as improved knock-out property or higher reclamation strength. Other interesting solutions might also be moulding sands bonded by geo-polymers and phosphate binders or salts and also binders based on degradable biopolymers. These tendencies and the usefulness of these binders are put forward in this paper. | Stanisaw M.Dobosz Petr Jelinek Katarzyna Major-Gabry | 2011 | China Foundry2011，8，4： | 11 |
| 2 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 3 | Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin显示文摘 | Jelin E Hirose S Rand L | 2010 | Fetal Diagn Ther2010，27，3： | 1 |
| 4 | Implication Of Glutathione in endemic Fluorosis显示文摘 | J Jelin Sharma S JOlly et al | 1985 | Fluoride1985，18，1： | 1 |
| 5 | Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma:a 25-year experience at a single institution显示文摘 | Shue E Bolouri M Jelin EB | 2013 | J Pediatr Surg2013，48，6： | 1 |
| 6 | Tumor metrics and morphology predict poor prognosis in prenatally diagnosed zacrococcygeal tcratoma: a 25-year experience at a single institution显示文摘 | Shue E Bolouri M Jelin E B | 2013 | J Pedialr Surg2013，48，6： | 1 |
| 7 | Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin显示文摘 | Jelin E Hirose S Rand L | 2010 | Fetal Diagn Ther2010，27，3： | 1 |
| 8 | Management of biliary tract disease during pregnancy: a decision analysis显示文摘 | Eric B. Jelin Douglas S. Smink Ashley H. Vernon David C. Brooks | 2008 | Surgical Endoscopy2008，，1： | 1 |
| 9 | Pefinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin 显示文摘 | Jelin E Hirose S Rand L | 2010 | Fetal Diagn Ther2010，27，： | 1 |
| 10 | Loss of imprinting and cancer 显示文摘 | JELINIC P SHAW P | 2007 | J Pathol2007，211，： | 1 |
| 11 | Early-onset preeclampsia and neonatal outcomes显示文摘 | Jelin A C Cheng Y W Shaffer B L | 2010 | J Matern Fetal Neonatal Med2010，23，5： | 1 |
| 12 | Effects of ventricular contraction sequence on hemodynamic and wall motion 显示文摘 | Cui CZ Jeline Fox Vincent GM | 1993 | Pace1993，16，： | 1 |
| 13 | Long-term outcomes after fetaltherapy for congenital high airway obstructive syndrome显示文摘 | Saadai P Jelin EB Nijagal A | 2012 | J PediatrSurg2012，47，6： | 1 |
| 14 | The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations:a report of 4 cases显示文摘 | Nijagal A Jelin E Feldstein VA | | 0，，8： | 1 |
| 15 | Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice显示文摘 | Miniati D Jelin EB Ng J | 2010 | Am J Physiol Lung Cell Mol Physiol2010，298，2： | 1 |
| 16 | Enhanced Uterine Artery Stiffness in Aged Pregnant Relaxin Mutant Mice Is Reversed with Exogenous Relaxin Treatment 显示文摘 | Gooi JH Richardson ML Jelinic M | 2013 | Biol Reprod2013，89，1： | 1 |
| 17 | Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome显示文摘 | Saadai P Jelin EB Nijagal A | | 0，，6： | 1 |
| 18 | Local injection of hyperosmolar glucose solution versus salpingotomy for tube-preserving therapy in women with unrruptured tubal pregnancy and a serum HCG level of 2500IU/L显示文摘 | Arikan GM Jeline KB Tamussino K | 2001 | Fertil Steril2001，75，4： | 1 |
| 19 | Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin显示文摘 | Jelin E Hirose S Rand L | 2010 | Fetal Diagn Ther2010，27，3： | 1 |
| 20 | Inspection of the distribution and amount of ingredients in pasteurized cheese by computer vision显示文摘 | Cheng-Jin Dub Jo'zef Fornal | 2007 | Journal of Food Engineering2007，，： | 1 |
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