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| 1 | Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation显示文摘AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its subscales.METHODS: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites States.IBS and IBS subtype were diagnosed using Rome-Ⅲ questionnaire.QOL was assessed using IBS-QOL questionnaire.IBSQOL assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on relationships.IBS-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better QOL.Results of overall IBS-QOL scores and subscale scores are expressed as means with 95%CI.We compared mean IBS-QOL score and its subscales among various IBSsubtypes.Analysis of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than 0.05.RESULTS: Of 542 patients screened,243 had IBS as per Rome-Ⅲ criteria.IBS-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationships(73.3,95%CI: 68.4-78.2 vs 84.7,95%CI: 77.2-92.2,P = 0.02) than IBS-C patients.Patients with IBS-M also scored significantly lower than IBS-C on food avoidance(47.2,95%CI: 40.7-53.7 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and social reaction(66.1,95%CI: 61.1-71.1 vs 80.0,95%CI: 72.1-87.7,P = 0.005).CONCLUSION: IBS-D and IBS-M patients have lower IBS-QOL than IBS-C patients.Clinicians should recognize food avoidance,effects on daily activities and relationship problems in these patients. | Prashant Singh Kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon Shahar Castel Braden Kuo | 2015 | World Journal of Gastroenterology2015，21，26： | 9 |
| 2 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 3 | Fourth order com- pact schemes of a heat conductions 显示文摘 | ZHAO JENNIFER DAI W Z NIU T C | 2007 | Wiley inter- Science2007，，： | 1 |
| 4 | Fourth-order compact schemes of a heat conduc- tion problem with Neumann boundary condition显示文摘 | Zhao Jennifer Dai Weizhong Niu Tianchan | 2007 | Numerical Methods for Partial Differential Equations2007，23，： | 1 |
| 5 | Petrology, mineralogy, and geochemistry of the Ge-rich coal from the Wulantuga Ge ore deposit, Inner Mongolia, China: New data and genetic implications显示文摘 | Shifeng Dai Xibo Wang Vladimir V. Seredin James C. Hower Colin R. Ward Jennifer M.K. O’Keefe Wenhui Huang Tian Li Xiao Li Huidong Liu Weifeng Xue Lixin Zhao | 2011 | International Journal of Coal Geology2011，，： | 1 |
| 6 | Fourth-order compact schemes of a heat conduction poblemwith Neumann boundary condition显示文摘 | Zhao Jennifer DAI Weizhong NIU Tianchan | 2007 | Numerical Methods for Paral Differential Equations2007，23，： | 1 |
| 7 | Attenuation of the September Epidemic of Asthma Exacerbations in Children: A Randomized, Controlled Trial of Montelukast Added to Usual Therapy 显示文摘 | Nell W Johnston Plush J Mandhane Jennifer Dai | 2007 | Pediatrics2007，120，3： | 1 |
| 8 | Complement and HIV-I infection/HIV-associated neurocognitive disorders显示文摘 | Fengming Liu Shen Dai Jennifer Gordon Xuebin Qin | 2014 | Journal of NeuroVirology2014，，2： | 1 |
| 9 | The Role of SATB2 in Skeletogenesis and Human Disease显示文摘 | Xiaoying Zhao Zhihu Qu Jennifer Tickner Jiake Xu Kerong Dai Xiaoling Zhang | 2013 | Cytokine and Growth Factor Reviews2013，，： | 1 |
| 10 | FTIR investigation of the interfacial properties and mechanisms of CO_(2) sorption in porous ionic liquids显示文摘Porous liquids,which are liquids with permanent porosity,have received significant attention as a new class of materials with the potential for far-reaching impacts in a variety of applications including gas separation.In this work,in situ Fourier transform infrared spectroscopy measurements were conducted to investigate the mechanism of carbon dioxide absorption in a porous ionic liquid consisting of ZIF-8 combined with 8,80-(3,6-dioxaoctane-1,8-diyl)bis(1,8-diazabicyclo[5.4.0]undec-7-en-8-ium)bis(trifluoromethanesulfonyl)imide([DBU-PEG][(Tf_(2)N)_(2)]).While the vibrational modes of the pure ionic liquid remain relatively unchanged,the incorporation of carbon dioxide leads to slight structural fluctuations in the ZIF-8 framework whether it is pure solid or as integrated into the porous ionic liquid.The analysis of the vibrational modes of the porous ionic liquid suggests that the interaction of the CO_(2) occurs more strongly with the ring structure of the ZIF-8 framework.The splitting of the asymmetric stretch of the CO_(2) into multiple peaks upon sorption indicate the presence of multiple environments,which could be a combination of free and physisorbed CO_(2) or simply multiple binding sites within the porous ionic liquid.A better understanding of gas sorption mechanisms in this unique material could lead to new porous ionic liquids with enhanced separations properties. | Jennifer A.Schott Chi-Linh Do-Thanh Weida Shan Nicolette G.Puskar Sheng Dai Shannon M.Mahurin | 2021 | Green Chemical Engineering2021，2，4： | 0 |
| 11 | Corrigendum to “Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference” [Genes & Diseases 5(2018):172–184]显示文摘The authors regret having several image assembly errors.Specifically,in Figure 3A panel b,the image for 'AdsimB9-4 only'group was erroneously duplicated with an overlapping image from the'AdRFp'group;and the image for'AdsimB9-1+BMP9'groupwas erroneouslyduplicatedwithan overlapping image from'AdsimB9-8+BMP9'group.In Figure 4Apanel a,the images for'BMP9'group and 'BMP9+simB9-4'group were erroneously duplicated with an overlapping image from'simB9-4'group.In Figure 5A,the image for'BMP9+simB9-4/Day3'group was erroneously duplicated with an overlapping image from'BMP9+simB9-7/Day3'group;and the image for'BMP9+simB9-4/Day5'group was erroneously duplicated with an overlapping image from an unrelated experiment.In Figure 6B,the image for'BMP9+simB9-7/Day 11'group was erroneously duplicated with an overlapping image from the'BMP9+simB9-4/Day 11'group. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C. Haydon Michael J. Lee Russell R. Reid Jennifer Moriatis Wolf Qiong Shi Hue H. Luu Tong-Chuan He Yaguang Weng | 2023 | Genes & Diseases2023，10，2： | 0 |
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