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| 1 | Post-infectious irritable bowel syndrome:Mechanistic insights into chronic disturbances following enteric infection显示文摘Irritable bowel syndrome(IBS)is a commonly encountered chronic functional gastrointestinal(GI)disorder.Approximately 10%of IBS patients can trace the onset of their symptoms to a previous a bout of infectious dysentery.The appearance of new IBS symptoms following an infectious event is defined as post-infectiousIBS.Indeed,with the World Health Organization estimating between 2 and 4 billion cases annually,infectious diarrheal disease represents an incredible international healthcare burden.Additionally,compounding evidence suggests many commonly encountered enteropathogens as unique triggers behind IBS symptom generation and underlying pathophysiological features.A growing body of work provides evidence supporting a role for pathogen-mediated modifications in the resident intestinal microbiota,epithelial barrier integrity,effector cell functions,and innate and adaptive immune features,all proposed physiological manifestations that can underlie GI abnormalities in IBS.Enteric pathogens must employ a vast array of machinery to evade host protective immune mechanisms,and illicit successful infections.Consequently,the impact of infectious events on host physiology can be multidimensional in terms of anatomical location,functional scope,and duration.This review offers a unique discussion of the mechanisms employed by many commonly encountered enteric pathogens that cause acute disease,but may also lead to the establishment of chronic GI dysfunction compatible with IBS. | Jennifer K Beatty Amol Bhargava Andre G Buret | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 2 | Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events显示文摘AIM: To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS: Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS: Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have signifi cantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer.CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. | Jennifer Y Wang Jonathan P Terdiman Eric Vittinghoff Tracy Minichiello Madhulika G Varma | 2009 | World Journal of Gastroenterology2009，15，8： | 8 |
| 3 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels显示文摘恶意的黑瘤,由侵略本地生长和转移的早形成描绘了,是皮癌症的最好攻击的类型。黑瘤禁止的活动(MIA ) ,由恶意的黑瘤房间藏匿了,与房间粘附受体, integrins 伪 4 尾 1 和伪 5 尾 1,便于的房间分开和转移的支持的形成交往。在现在的学习,我们证明那 MIA 分泌物被限制到移植房间的后面的目的,当在非移居的房间 MIA 在肌动朊外皮积累时。MIA 蛋白质包括上衣蛋白质建筑群拿一条常规能分泌的小径我(COPI )- 并且上衣蛋白质建筑群 II (COPII ) 依赖者蛋白质运输到房间圆周,在它的最后的版本取决于细胞内部的 Ca2+ 离子的地方。有趣地,激活 Ca2+ 的 K+ 隧道,亚科 N,成员 4 (KCa3.1 ) ,知道在移植房间的后面的结束活跃,被发现支持 MIA 分泌物。分泌物被特定的 KCa3.1 隧道禁止者 TRAM-34 并且由隧道的主导否定的异种的表示减少。在摘要,我们阐明了到房间尾部并且也的 MIA 蛋白质的联系迁居的运输揭示了 KCa3.1 钾隧道由支持房间移植的新机制。 | Jennifer Schmidt Kristin Friebel Roland Schoenherr Marc G Coppolino Anja-Katrin Bosserhoff | 2010 | Cell Research2010，20，11： | 3 |
| 6 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 7 | The relationship between the mechanical properties and cell behaviour on PLGA and PCL scaffolds for bladder tissue engineering显示文摘 | Simon C. Baker Géraldine Rohman Jennifer Southgate Neil R. Cameron | 2008 | Biomaterials2008，，7： | 2 |
| 8 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 9 | Investigating interactions of trust and interest similarity 显示文摘 | Cai-Nicolas Z Jennifer G | 2007 | Decision Support Systems2007，43，2： | 1 |
| 10 | Three-dimensional imaging of orthodontic model:a pilot study显示文摘 | JENNIFER A TOBY G PETER M | 2007 | European Journal of Orthodontics2007，，29： | 1 |
| 11 | Applications for activated carbons from used tires : Butane working capacity 显示文摘 | JAN L A JENNIFER L G PETER C E | 1999 | Carbon1999，37，9： | 1 |
| 12 | Application oftransient infrared and near infrared spectroscopy totransition metal complex excited states and inter-mediates显示文摘 | Jennifer M B Michael W G Jon R S | 2007 | Coord Chem Rev2007，251，： | 1 |
| 13 | Mohs surgery:Commentaries and conroversies显示文摘 | Carlos G Jennifer H Eduardo P | 2005 | Int J Dermatol2005，44，： | 1 |
| 14 | The Experience and Evolution of Trust:Implications for Cooperation and Teamwork显示文摘 | JONES G R GEORGE JENNIFER M | 1998 | Academy of Management Review1998，23，： | 1 |
| 15 | The relationship among national institutional structures,economic factors,and domestic entrepreneurial activity:a multicountry study显示文摘 | Jennifer W S Carolina G | 2004 | Journal of Business Research2004，57，10： | 1 |
| 16 | A New Classification System Predictive of Complications in Surgically Treated Pediatric Humeral Lateral Condyle Fractures 显示文摘 | Jennifer MW Sara G Scott Y | 2009 | J Pediatr Orthop2009，29，6： | 1 |
| 17 | Idiopathic pulmonary fibrosis: Challenges and opportunities for the clinician and investigator显示文摘 | Jeffrey J Ware G Jennifer L | 2005 | Chest2005，127，1： | 1 |
| 18 | Offshore outsourcing decision making: A policy-maker's perspective显示文摘 | Youxu Cai Tjader Jennifer S Shang Luis G Vargas | 2010 | European Journal of Operational Research2010，207，1： | 1 |
| 19 | Clinical relevance of cytogenetic abnormalities at diagnosis of acquired aplastic anaemia in adults显示文摘 | Vikas G Carol B Jennifer A | 2006 | Br J Haematol2006，134，6： | 1 |
| 20 | Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1显示文摘 | Jennifer A Whitaker Nadine G Rouphael Srilatha Edupuganti Lilin Lai Mark J Mulligan | 2012 | The Lancet Infectious Diseases2012，，12： | 1 |
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